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DNA Damage, Mutation and Cancer

Gordon Research Conference

Genomic Stability: Oncogenesis Therapy and Its Short- and Long-Term Toxicities

March 1 - 6, 2026

Chair

Vice Chair

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The DNA Damage, Mutation and Cancer GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "DNA Damage, Mutation and Cancer" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: At the Interface of Genomic Stability and Immunity Discussion Leader:
7:40 pm - 8:20 pm	"Fundamental Roles of Cohesin-Mediated Chromatin Loop Extrusion Antibody Gene Diversification"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	"DNA Immunity - How cGAS Senses DNA as Danger"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Targeting DNA Replication and Recombination in Cancer Discussion Leader:
9:00 am - 9:15 am	"Megabase Genomic Loss from DNA Double-Strand Breaks"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"BRCA1 Separation-of-Function Alleles in Stalled Fork Repair and FANCM Synthetic Lethality"
9:35 am - 9:40 am	Discussion
9:40 am - 9:50 am	"Elucidating the Molecular Mechanism of TIRR-Mediated p53 Inhibition: From Transcriptional Control to RNA Stability"
9:50 am - 9:55 am	Discussion
9:55 am - 10:10 am	"Fork Coupling Maintains DNA Replication Elongation under Replication Stress"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"BRCA2 Deficiency and Replication Stress Drive APOBEC3-Mediated Genomic Instability"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Group Photo / Coffee Break
11:00 am - 11:15 am	"Mapping Genetic Adaptation to BRCA1 and BRCA2 Loss: Divergent Vulnerabilities and Therapeutic Opportunities"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Targeting the p53-Pol iota Interaction Induces Single-Stranded DNA Gaps and Enhances PARP Inhibitor Efficacy in HR-Proficient Cancers"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Replication Stress-induced RDC Gene Fragility Results from Single-ended DNA Breaks at Replication Termination Zones"
11:50 am - 11:55 am	Discussion
11:55 am - 12:10 pm	"Mechanisms For RNA-Mediated Genome Instability"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"A single BRCA2 BRC Repeat Supports Viability, while Multiple Repeats ensure Resilience under Stress"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Emerging Technology and New Insights in Studying Genomic Instability Discussion Leader:
7:30 pm - 7:45 pm	"Scaling Genome Editing to Understand Genome Stability"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"Programmable Cell Elimination Via CRISPR-mediated DNA Damage"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"DNA Damage Responses in Mitotic and Post Mitotic Cells"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"Mapping the Genetic Landscape of Replication Stress Recovery: A CRISPR-Interference Screen for DNA Replication Resumption Factors"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Dissecting the DNA Damage Response Network"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Regulators, Effectors, & Modulators of Structural Variants"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Structural and Biochemical Insights of DNA repair and Damage Sensing Discussion Leader:
9:00 am - 9:15 am	"Recognition and Removal of DNA Lesions"
9:15 am - 9:20 am	Discussion
9:20 am - 9:30 am	"Structural Basis of Transcriptional Stalling at 8-Oxoguanine Lesions by RNA Polymerases"
9:30 am - 9:35 am	Discussion
9:35 am - 9:45 am	"Breaking down R-Loop Resolution one Protein Molecule at a time with RAD52, CSA, CSB, and DSS1"
9:45 am - 9:50 am	Discussion
9:50 am - 10:05 am	"Mechanisms of Transcription-Coupled Repair"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	"The CST Complex Suppresses the Toxicity of R-loops/G4s in ARID1A Deficient Cancer Cells"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:10 am	"The Mre11-Rad60-Nbs1 (MRN) Complex and Functions in DNA Repair"
11:10 am - 11:15 am	Discussion
11:15 am - 11:30 am	"Mechanism of Trinucleotide Repeat Expansion by MutSß-MutLg and Contraction by FAN1"
11:30 am - 11:35 am	Discussion
11:35 am - 11:50 am	"APOBEC Mutagenesis and Carcinogenesis Exacerbated by DNA-Adducting Agents, including those in Tobacco Smoke"
11:50 am - 11:55 am	Discussion
11:55 am - 12:10 pm	"Understanding and Targeting Human Nucleotide Excision Repair"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Novel MutLa Functions in Genome Maintenance and Cancer Therapy"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Aneuploid, ecDNA, and other Floating Sequences Discussion Leader:
7:30 pm - 7:45 pm	"Complex Recombination Phenotyping at Scale in Rare Disease Patient-Derived DNA Repair Gene Knockouts"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	"Replication Termination as a Source of Genomic Instability"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Pan-Cancer Analysis of SF3B1 Mutations in Solid Tumors"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Detection and Quantification of Cancer-Associated Mutagenic Processes in Normal Human Somatic Cells"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:00 pm	"The Development of New Types of Human Artificial Chromosomes"
9:00 pm - 9:10 pm	Discussion
9:10 pm - 9:20 pm	"NONO in Safeguarding Genome Stability and Suppressing Erroneous Cytosolic DNA Accumulation and cGAS Activation"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The End-Joining Pathways and Chromosomal Translocations Discussion Leader:
9:00 am - 9:15 am	"Deciphering the Molecular Blueprint of NHEJ-Mediated DNA Repair"
9:15 am - 9:20 am	Discussion
9:20 am - 9:30 am	"Human DNA-PKcs Prevents Ku Overloading to ensure Efficient End-Tethering during NHEJ"
9:30 am - 9:35 am	Discussion
9:35 am - 9:50 am	"A Specialized End-Joining Pathway Repairs DNA Double-Strand Breaks in Transcriptionally Active Regions"
9:50 am - 9:55 am	Discussion
9:55 am - 10:10 am	"Holding it Together: Visualizing Non-Homologous End Joining"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"53BP1 Condensates Function as Bioreactors for NHEJ directed DNA Repair and Insulators to determine Pathway Choice"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:15 am	"The Coordination of NHEJ Repair"
11:15 am - 11:20 am	Discussion
11:20 am - 11:30 am	"Mechanisms Governing Radial Chromosome Formation"
11:30 am - 11:35 am	Discussion
11:35 am - 11:45 am	"Mechanisms Regulating Theta-Mediated End Joining"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Genetic Control of Chromosomal Break Repair Outcomes"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Signatures of Neuronal Somatic Mutations Identify Mechanisms of DNA Damage in Aging and Neurodegeneration"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Instability at the Genomic Dark Matters from Repeats to Mitochondria DNA Discussion Leader:
7:30 pm - 7:45 pm	"Mitochondrial Nucleic Acid Signaling in Immunity and Cancer"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"Understanding Extrachromosomal Telomere DNA Generation in ALT Cancer Cells: Okazaki Fragment Processing Shapes C-circle Formation"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Ribosomal DNA Instability and Repair in Human Disease"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"G-Quadruplexes Direct Homologous Recombination Beyond BRCA1"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"DNA Structure-Induced Genetic Instability in Cancer"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"DNA Replication and Damage Response of Pathogenic AAGGG Repeats in Cultured Human Cells"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Molecular Mechanism and Cellular Consequence of Genomic Instability Discussion Leader:
9:00 am - 9:15 am	"Molecular Patterns of DNA Damage Directed Immune Responses"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Replication and Replication Checkpoint Control"
9:35 am - 9:40 am	Discussion
9:40 am - 9:50 am	"Targeting ALC1 ATPase Activity as a New Synthetic Lethal Strategy in BRCA-Mutant Cancers"
9:50 am - 9:55 am	Discussion
9:55 am - 10:10 am	"Insights into BRCA1-Associated Breast Cancer Development from Integrated Whole Genome Analysis of Mouse Model Mammary Tumors"
10:10 am - 10:15 am	Discussion
10:15 am - 10:30 am	"PARP1-Induced Nuclear RNA Condensates Link DNA Damage to Translation Arrest"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:20 am	"RNF25 Confers Tolerance to Azacytidine-Induced mRNA Damage"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"DNA polymerase iota alleviates replication stress-induced genome instability during mitosis"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Formation and Repair of DNA-Protein Cross-Links"
11:50 am - 11:55 am	Discussion
11:55 am - 12:10 pm	"Mechanistic Analysis of Break-Induced Replication in Mammalian Cells"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"HDAC Inhibition Disrupts the DNA Damage Response via Global Redistribution of Transcriptional Machinery and Sensitizes Pancreatic Tumors to DNA-Damaging Therapies"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cancer Therapy From Targets To Toxicities Discussion Leader:
7:30 pm - 7:45 pm	"Replication-Stress–Induced DNA Breaks: Origins, Dynamics and Consequences"
7:45 pm - 7:55 pm	Discussion
7:55 pm - 8:05 pm	"Interplay between Protein and DNA Damage in Methylglyoxal-Mediated Genome Instability"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Bridging DNA Repair and Replication: Emerging Factors and Regulatory Paradigms"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"Divergent somatic mutation patterns among human cerebellar neuron types"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Targeting Replication Stress in Cancer Therapy"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Investigating Dysregulated DNA Replication Forks as Targets for Formaldehyde Mutagenesis"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA309912. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History DNA Damage, Mutation and Cancer (GRS)

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