Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Chasing 53BP1 Down the Rabbit Hole
Discussion Leaders: Natalie Saini (National Institute of Environmental Health Sciences, NIH, USA) and Sara Martin (University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, USA)
3:45 pm - 4:20 pm
Daniel Durocher (Lunenfeld-Tanenbaum Research Institute, Canada)
"Chasing 53BP1 Down the Rabbit Hole"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms of Genome Instability
Discussion Leaders: Brittany Carroll (University of Vermont, USA) and Ryan Barnes (University of Pittsburgh, USA)
7:30 pm - 7:45 pm
Kah Suan Lim (Dana-Farber Cancer Institute, USA)
"USP1 Is Required for Replication Fork Stability in BRCA1-Deficient Tumors"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Matthew Puccetti (Vanderbilt University, USA)
"DNA Replication Fork Remodeling Proteins Are Essential for Mediating Myc-Driven Replication Stress"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Yaqun Teng (University of Pittsburgh Cancer Institute, USA)
"Oxidative Damage Triggers CSB-RAD52 Mediated RNA-Templated Recombination"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Xiao-Feng Zheng (Dana-Farber Cancer Institute, USA)
"CDK5-PP4 Kinase-Phosphatase Signaling Cascade Drives the Recruitment of 53BP1 to Double-Strand Breaks"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Zhenxin Yan (Baylor College of Medicine, USA)
"Rad52 Is a Novel Regulator of DNA Double-Strand Break End Resection in Fission Yeast"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Tatiana Moiseeva (University of Pittsburgh, USA)
"ATR/Chk1 Signaling Controls Replication Initiation in Undamaged Cells"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cancer-Associated Mutations and Novel Therapeutic Targets
Discussion Leaders: Mark Drost (Leiden University Medical Center, The Netherlands) and Judit Jimenez Sainz (Yale School of Medicine, USA)
9:00 am - 9:15 am
Stephanie Barbari (University of Nebraska Medical Center, USA)
"Characterizing DNA Polymerase Epsilon Mutations Found in Hypermutated Tumors"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Sotirios Sotiriou (University of Geneva, Switzerland)
"Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Zubaidah Ramdzan (Goodman Cancer Centre, McGill University, Canada)
"Acute Dependence of Cancer Cells on Base Excision Repair Auxiliary Factors"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Cynthia Sakofsky (National Institute of Environmental Health Sciences, NIH, USA)
"Hypermutation Associated with Bursts of Double-Strand Breaks"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Audrey Turchick (Yale University, USA)
"The Cell-Penetrating Antibody 3E10 Inhibits RAD51 and Is Selectively Cytotoxic to PTEN-Deficient Cells"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Amy Whitaker (University of Kansas Medical Center, USA)
"Molecular Insight into APE1 Mutations Associated with Human Disease"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Finding Your Path in Science
Discussion Leaders: Ahmed Diab (Fred Hutchinson Cancer Research Center, USA) and Alice Lallo (Cancer Research UK Manchester Institute, United Kingdom)
1:30 pm - 2:30 pm
Panel Discussion
Finding Your Path in Science
Marc Chatenay-Lapointe (Knobbe, Martens, Olson & Bear, LLP, USA)
Daniel Durocher (Lunenfeld-Tanenbaum Research Institute, Canada)
Laurence Ettwiller (New England Biolabs, USA)
Jane Kim (California State University San Marcos, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
