|
Saturday
|
| 2:00 pm - 5:00 pm |
Arrival and Check-in
|
| 3:30 pm - 3:45 pm |
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
|
| 3:45 pm - 4:30 pm |
Keynote Session: Chasing 53BP1 Down the Rabbit Hole
Discussion Leaders: Natalie Saini (National Institute of Environmental Health Sciences, NIH, USA) and Sara Martin (University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, USA)
|
| 3:45 pm - 4:20 pm |
Daniel Durocher (Lunenfeld-Tanenbaum Research Institute, Canada)
"Chasing 53BP1 Down the Rabbit Hole"
|
| 4:20 pm - 4:30 pm |
Discussion
|
| 4:30 pm - 6:00 pm |
Poster Session
|
| 6:00 pm - 7:00 pm |
Dinner
|
| 7:30 pm - 9:30 pm |
Mechanisms of Genome Instability
Discussion Leaders: Brittany Carroll (University of Vermont, USA) and Ryan Barnes (University of Pittsburgh, USA)
|
| 7:30 pm - 7:45 pm |
Kah Suan Lim (Dana-Farber Cancer Institute, USA)
"USP1 Is Required for Replication Fork Stability in BRCA1-Deficient Tumors"
|
| 7:45 pm - 7:50 pm |
Discussion
|
| 7:50 pm - 8:05 pm |
Matthew Puccetti (Vanderbilt University, USA)
"DNA Replication Fork Remodeling Proteins Are Essential for Mediating Myc-Driven Replication Stress"
|
| 8:05 pm - 8:10 pm |
Discussion
|
| 8:10 pm - 8:25 pm |
Yaqun Teng (University of Pittsburgh Cancer Institute, USA)
"Oxidative Damage Triggers CSB-RAD52 Mediated RNA-Templated Recombination"
|
| 8:25 pm - 8:30 pm |
Discussion
|
| 8:30 pm - 8:45 pm |
Xiao-Feng Zheng (Dana-Farber Cancer Institute, USA)
"CDK5-PP4 Kinase-Phosphatase Signaling Cascade Drives the Recruitment of 53BP1 to Double-Strand Breaks"
|
| 8:45 pm - 8:50 pm |
Discussion
|
| 8:50 pm - 9:05 pm |
Zhenxin Yan (Baylor College of Medicine, USA)
"Rad52 Is a Novel Regulator of DNA Double-Strand Break End Resection in Fission Yeast"
|
| 9:05 pm - 9:10 pm |
Discussion
|
| 9:10 pm - 9:25 pm |
Tatiana Moiseeva (University of Pittsburgh, USA)
"ATR/Chk1 Signaling Controls Replication Initiation in Undamaged Cells"
|
| 9:25 pm - 9:30 pm |
Discussion
|
|
Sunday
|
| 7:30 am - 8:30 am |
Breakfast
|
| 9:00 am - 11:00 am |
Cancer-Associated Mutations and Novel Therapeutic Targets
Discussion Leaders: Mark Drost (Leiden University Medical Center, The Netherlands) and Judit Jimenez Sainz (Yale School of Medicine, USA)
|
| 9:00 am - 9:15 am |
Stephanie Barbari (University of Nebraska Medical Center, USA)
"Characterizing DNA Polymerase Epsilon Mutations Found in Hypermutated Tumors"
|
| 9:15 am - 9:20 am |
Discussion
|
| 9:20 am - 9:35 am |
Sotirios Sotiriou (University of Geneva, Switzerland)
"Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks"
|
| 9:35 am - 9:40 am |
Discussion
|
| 9:40 am - 9:55 am |
Zubaidah Ramdzan (Goodman Cancer Centre, McGill University, Canada)
"Acute Dependence of Cancer Cells on Base Excision Repair Auxiliary Factors"
|
| 9:55 am - 10:00 am |
Discussion
|
| 10:00 am - 10:15 am |
Cynthia Sakofsky (National Institute of Environmental Health Sciences, NIH, USA)
"Hypermutation Associated with Bursts of Double-Strand Breaks"
|
| 10:15 am - 10:20 am |
Discussion
|
| 10:20 am - 10:35 am |
Audrey Turchick (Yale University, USA)
"The Cell-Penetrating Antibody 3E10 Inhibits RAD51 and Is Selectively Cytotoxic to PTEN-Deficient Cells"
|
| 10:35 am - 10:40 am |
Discussion
|
| 10:40 am - 10:55 am |
Amy Whitaker (University of Kansas Medical Center, USA)
"Molecular Insight into APE1 Mutations Associated with Human Disease"
|
| 10:55 am - 11:00 am |
Discussion
|
| 11:00 am - 12:30 pm |
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
|
| 12:30 pm - 1:30 pm |
Lunch
|
| 1:30 pm - 2:30 pm |
Mentorship Component: Finding Your Path in Science
Discussion Leaders: Ahmed Diab (Fred Hutchinson Cancer Research Center, USA) and Alice Lallo (Cancer Research UK Manchester Institute, United Kingdom)
|
| 1:30 pm - 2:30 pm |
Panel Discussion
Finding Your Path in Science
-
Marc Chatenay-Lapointe (Knobbe, Martens, Olson & Bear, LLP, USA)
-
Daniel Durocher (Lunenfeld-Tanenbaum Research Institute, Canada)
-
Laurence Ettwiller (New England Biolabs, USA)
-
Jane Kim (California State University San Marcos, USA)
|
| 2:30 pm - 3:00 pm |
Evaluation Period
Fill in GRS Evaluation Forms
|
| 3:00 pm |
Seminar Concludes
|
