Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Topoisomerase World from Phylogeny to Molecular Structures
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Evolution and Diversity of Topoisomerases"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Type II Topoisomerases as Mediators of Mechanical Stress"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Antibacterial Drugs Targeting Topoisomerases and Antibiotic Resistance
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Microcin B17, a Microbial Toxin that Targets DNA Gyrase: Activity, Biosynthesis and Impact on Human Health"
9:40 am - 9:55 am
Discussion
9:55 am - 10:25 am
Coffee Break
10:25 am - 10:55 am
"Targeting Topoisomerase I of M. tuberculosis with Small Molecule Inhibitors"
10:55 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Targeting Bacterial Topoisomerase I as Countermeasure for Antibiotic Resistance"
11:40 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Direct Observation of Type IA Topoisomerase Gate Opening"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Mechanistic Framework for DNA Gyrase: DNA Wrapping Thermodynamics Governs Supercoiling Efficiency in E. coli Gyrase"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Anticancer Drugs Targeting Topoisomerases: The Challenge to Make Them Better
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Topoisomerase I Poisons and DNA Repair Inhibitors: Improved Efficacy or Enhanced Toxicity?"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"Targeted Delivery of Topoisomerase Inhibitors: Are We There Yet?"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Update on Preclinical and Clinical Development of Topoisomerase I Inhibitor Exatecan-Derivative Based Antibody-Drug Conjugate (DXd-ADC)"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Topoisomerases and Chromatin Structure
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Genome Organization Drives Chromosome Instability"
9:40 am - 9:55 am
Discussion
9:55 am - 10:25 am
Coffee Break
10:25 am - 10:55 am
"DNA Supercoiling and the Smc5/6 Complex"
10:55 am - 11:10 am
Discussion
11:10 am - 11:40 am
"The Role of Topoisomerase II Beta (TOP2B) in Transcriptional Regulation"
11:40 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"A Bacterial Chromosome Structuring Protein Stimulates Type II Topoisomerases and Enables DNA Replication"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Ciprofloxacin Impairs Mitochondrial DNA Replication Initiation Through Inhibition of Topoisomerase 2"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Topoisomerases, Transcription and RNA Topoisomerases
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Evidence that Topoisomerase III Beta (TOP3B) Is a Dual Activity Topoisomerase that Can Act on both DNA and RNA"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"The Interplay Between DNA Structure, Torsional Stress and Transcription in Mammalian Cells"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"DNA Break and Damage Response Signaling Coupled with RNA Polymerase II Promoter-Proximal Pause Release and Processive Elongation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Topoisomerase-Induced Damage
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Topoisomerase I as a Driver of Genetic Change in Yeast"
9:40 am - 9:55 am
Discussion
9:55 am - 10:25 am
Coffee Break
10:25 am - 10:55 am
"DNA Repair Proteins Involved in the Repair of Pathological Topoisomerase II Cleavage Complexes"
10:55 am - 11:10 am
Discussion
11:10 am - 11:40 am
"Regulation of the Repair of Topoisomerase II Covalent Complexes"
11:40 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Mechanisms Antagonizing Ku at Single-Ended DNA Double-Strand Breaks Induced by Topoisomerase I Poisons"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Alternative End Joining Is a Major Pathway for the Repair of Top2-Mediated DSBs"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Repair of Topoisomerase-Induced Damage
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Mechanisms of TOP2 DNA-Protein Crosslink Repair"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"Topoisomerase Damage and Repair in Mitochondria"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"PRMT5-Mediated Arginine Methylation of TDP1 for the Repair of Topoisomerase I Covalent Complexes"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Topoisomerases and Human Diseases (Neurodegenerative Diseases and Cancers)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Pathogenic Topoisomerase I Activity in Neurologic Disease"
9:40 am - 9:55 am
Discussion
9:55 am - 10:25 am
Coffee Break
10:25 am - 10:55 am
"Neurodegeneration at the Interface Between DNA Repair and Autophagy"
10:55 am - 11:10 am
Discussion
11:10 am - 11:40 am
"The Role of Activity-Induced DNA Breaks in Neuronal Physiology and Disease"
11:40 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Topoisomerase 3a Is Required for Separation of Human Mitochondrial DNA"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Direct Regulation of Topoisomerase Activity as a Mean to Control Transcription"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tyrosyl DNA Phosphodiesterases, Recombinations, Mitochondrial and Viral Replication
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Tyrosyl DNA Phosphodiesterase (TDP) Proteins in DNA Repair and Disease"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"The Role of Polynucleotide Kinase/Phosphatase in DNA Repair and Its Potential as a Therapeutic Target"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Insights into the Mechanisms of DNA Supercoiling, Relaxation and Decatenation by Type II Topoisomerases"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure