Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: How Deep is the Rabbit Hole: The Unending Complexities of the First DNA Remodeling Machines
Discussion Leader: Alexandria Oviatt (Vanderbilt University, United States)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
James Berger (Johns Hopkins University School of Medicine, United States)
"How Deep is the Rabbit Hole: the Unending Complexities of the First DNA Remodeling Machines"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymology of DNA Topoisomerases and Compounds Targeting
Discussion Leader: Victoria Baskerville (John Innes Centre, United Kingdom)
7:30 pm - 7:45 pm
Somaia Haque Chadni (Florida International University, United States)
"Investigation of Covalent Inhibitors for Type IA Topoisomerases"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Jessica Collins (Vanderbilt University School of Medicine, United States)
"Actions of Spiropyrimidinetriones Against Bacterial Type II Topoisomerases"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Chelsea Mann (The Ohio State University College of Pharmacy Division of Medicinal Chemistry and Pharmacognosy, United States)
"Tricyclic Amide Novel Bacterial Topoisomerase Inhibitors: SAR and Human Topoisomerase IIa Inhibitory Activity"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Sourav Saha (National Cancer institute, NIH, United States)
"Resolution of R-Loops by Topoisomerase III-beta (TOP3B) in Coordination with the DEAD-box Helicase DDX5"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Vaibhav Prakash Mhaindarkar (Institute for Physical Chemistry, University of Muenster, Germany)
"Analysis of DNA- and nucleotide-induced conformational changes in reverse gyrase by hydrogen-deuterium exchange mass spectrometry"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Ian Morgan (National Institutes of Health, United States)
"Getting Stressed Over Topoisomerase II Poisons: a Single-Molecule Approach for Uncovering the Molecular Mechanisms of Topoisomerase II Poisons"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Cellular Functions of Topoisomerase and Therapeutics
Discussion Leaders: Yasir Mamun (Florida International University, United States)
9:00 am - 9:30 am
Laura Baranello (Karolinska Institutet, Sweden)
"The Regulation of Transcription by Topoisomerases, Supercoiling and MYC: a New Twist for Anticancer Approaches"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
José Terrón-Bautista (Spanish National Cancer Research Center (CNIO), Spain)
"Topoisomerase II Activity in ERa Signaling as a Model of Transcriptional Regulation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Judith Benoit (University of Cambridge, United Kingdom)
"Investigating the Role of Topoisomerase II alpha in Mitosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Peter Lin (University of Toronto, Canada)
"An Isogenic CRISPR Knock-Out Screen Identifies TOP1 as a Novel MYC-dependent Vulnerability"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Ilse Delint Ramirez (UT southwestern medical center, United States)
"Calcineurin Signaling Regulates the Formation of Activity-Induced DNA breaks by Dephosphorylating Topoisomerase IIb at the Nuclear Periphery"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Panel Discussion on Careers
Discussion Leader: Eddy Alfonso (Florida International University, United States)
1:30 pm - 2:30 pm
Panel Discussion
Careers
Maarten Vercruysse (Roche, Switzerland)
Valerie Lamour (Institut de Génétique et de Biologie Moléculaire et Cellulaire , France)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
