| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Drug Carriers - Transforming Medicine Now and in the Future |
| Discussion Leader: Phil Low (Purdue University) |
| 7:40 pm - 8:20 pm | Jim Baker (University of Michigan)
"Why Nanoscale Drug Carriers Matter for Medicine"
|
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | Krystof Bankiewicz (University of California, San Francisco)
"Delivering Viral Vectors and Nanoparticles Across the Blood-Brain-Barrier, Translational and Clinical Experience"
|
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Trafficking Mechanisms, Intracellular Uptake and Transport of Drug Carriers |
| Discussion Leader: Vladimir Muzykantov (University of Pennsylvania) |
| 9:00 am - 9:30 am | Marino Zerial (Max Planck Institute of Molecular Cell Biology and Genetics)
"Harnessing Endocytosis for siRNA Delivery"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Kirsten Sandvig (Oslo University Hospital)
"Endocytic Mechanisms and Intracellular Transport of Drug Carriers"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Group Photo / Coffee Break |
| 11:00 am - 11:30 am | Gerald Wong (University of California, Los Angeles)
"Deterministic Design of Transporter Sequences for Cellular Delivery
Applications"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Warren Chan (University of Toronto)
"The Complexities of Nanoparticle Tumor Targeting"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Nanoengineered Systems for Targeted Cancer Therapy |
| Discussion Leader: Sasha Kabanov (University of North Carolina at Chapel Hill) |
| 7:30 pm - 8:00 pm | Dane Wittrup (Massachusetts Institute of Technology)
"Tumor Targeting, Theory and Experiment"
|
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Kit Lam (University of California, Davis)
"Multimodal Theranostic Nanoporphyrin for Chemo, Radio and Phototherapy"
|
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jesus Gonzalez (Avelas Biosciences)
"In Vivo Delivery of Molecular Cargo Using Protease-Activated Peptides: Cancer Applications"
|
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Vaccine Carriers, Mucosal Barriers and Immunotherapy |
| Discussion Leader: Art Levine (Avidity Nanomedicines) |
| 9:00 am - 9:30 am | David Mooney (Harvard University)
"Biomaterials as Therapeutic Cancer Vaccines"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Jeff Hubbell (University of Chicago)
"Molecular Engineering for Antigen Delivery in Induction of Tolerance and Immunity"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Darrell Irvine (Massachusetts Institute of Technology)
"Engineering Enhanced Vaccines and Immunotherapies with Hitchhiking Therapeutics"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Dan Peer (Tel-Aviv University)
"Manipulating Leukocytes' Function Using Targeted Nanoparticles: Hurdles and Opportunities"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Engineered Protein Delivery Systems and Protein Materials |
| Discussion Leader: Pat Stayton (University of Washington) |
| 7:30 pm - 8:00 pm | Steven Schwendeman (University of Michigan)
"Aqueous Microencapsulation of Large Molecules in PLGA Delivery Systems"
|
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Matt Francis (University of California, Berkeley)
"Synthetically Modified Viral Capsids as Vehicles for Targeted Delivery"
|
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Omolola Eniola Adefeso (University of Michigan)
"Understanding the Role of Plasma Proteins and Blood Cells in Vascular-Targeted Drug Carrier Design and Functionality"
|
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Emerging Polymeric Systems |
| Discussion Leader: Ruth Duncan (Cardiff University) |
| 9:00 am - 9:30 am | Karen Wooley (Texas A&M University)
"Therapeutic Polymer Nanoparticles Designed for Treatment of Pulmonary and Urinary Tract Diseases"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Molly Stevens (Imperial College London)
"New Biomaterials Approaches for Biosensing"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Adah Almutairi (Center of Excellence in Nanomedicine & Engineering, UC San Diego)
"The Art of Falling Apart in Health Sciences: Polymeric Materials Capable of Controlled Depolymerization"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Frank Caruso (University of Melbourne)
"Nanoscale Engineering of Polymer Carriers for Biological Interactions"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Late-Breaking Topics / Young Investigator Presentations |
| Discussion Leaders: Jan Schnitzer (PRISM) and Paula Hammond (Massachusetts Institute of Technology) |
| 7:30 pm - 7:45 pm | Julie Champion (Georgia Institute of Technology)
"Therapeutic Protein Nanoparticles that Subvert Intracellular Signaling for Immunomodulation as a Treatment for IBD"
|
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Denise Bamberger (Johannes Gutenberg University Mainz)
"Dynamic Polysaccharide Based Carrier Systems for the Delivery of RNA and DNA"
|
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Jan Kamps (University Medical Center Groningen)
"Targeted SAINT-O-Somes Enable Endothelial Cell Specific Delivery of siRNA and Downregulation of (Pro)Inflammatory Genes In Vivo"
|
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Zhenjia Wang (Washington State University)
"Nanoparticle Targeting of Adherent Neutrophils Prevents Vascular Inflammatory Disease"
|
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Craig Duvall (Vanderbilt University)
"Nano-Polyplex MK2 Inhibitory Peptide Delivery Inhibits Vascular Graft Intimal Hyperplasia"
|
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Michael Burr (University of Utah)
"Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration"
|
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Targeted Systems for Imaging and Theranostic Applications / RNA Delivery for Therapeutic and Vaccine Applications |
| Discussion Leader: Theresa Reineke (University of Minnesota) |
| 9:00 am - 9:30 am | Ick Chan Kwon (Korea Institute of Science and Technology)
"Role of Molecular Imaging in Designing Drug Carriers"
|
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Michelle Bradbury (Memorial Sloan-Kettering Cancer Center)
"Multimodal Silica Nanoparticles as Targeted Drug Delivery Vehicles for Cancer Therapeutics"
|
| 10:15 am - 10:30 am | Discussion |
| 10:30 am - 11:00 am | Coffee Break |
| 11:00 am - 11:30 am | Muthiah Manoharan (Alnylam)
"Advances in Systemic Delivery of RNAi Therapeutics"
|
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Andrew Geall (Novartis)
"Reinventing the Gene Vaccine: Non-Viral Delivery of Self-Amplifying mRNA Vaccines"
|
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Ocular Delivery |
| Discussion Leader: James Cunningham (Allergan) |
| 7:30 pm - 8:00 pm | Tejal Desai (University of California, San Francisco)
"Nanoporous Thin Film Devices for Ocular Drug Delivery"
|
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | David Schaffer (University of California, Berkeley)
"Molecular Engineering and Evolution of New Viruses for Therapeutic Gene Delivery"
|
| 8:45 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Joseph Ciolino (Harvard Medical School)
"Contact Lens Drug Delivery"
|
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |