Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Drug Delivery Revolution
Discussion Leader: Suzie Pun (University of Washington, United States)
7:40 pm - 8:20 pm
Laura Sepp-Lorenzino (Intellia Therapeutics, United States)
"Realizing the Promise of CRISPR Therapeutics"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Joseph Desimone (Stanford University, United States)
"Drug and Genomic Medicines Made Using Digital Fabrication Techniques and Multiphase Synthetic Approaches"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipid Nanoparticles in Drug Delivery
Discussion Leader: Gaurav Sahay (Oregon State University, United States)
9:00 am - 9:30 am
Matthew Stanton (Generation Bio, United States)
"Non-Viral DNA Delivery: Selectivity for Liver, T Cells and Beyond"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Cecilia Leal (University of Illinois at Urbana-Champaign, United States)
"Structural Complexity of Lipid Nanoparticles: Implications for Efficient and Organ-Specific Gene Delivery"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Michael Mitchell (University of Pennsylvania, United States)
"Lipid Nanoparticles for Overcoming Biological Barriers to mRNA Delivery"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Marino Zerial (Human Technopole, Italy)
"Role of Forces in Membrane Dynamics and Tissue Morphogenesis"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Elizabeth Nance (University of Washington, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Carriers for Reproductive Health
Discussion Leader: Rachel Riley (Rowan University, United States)
7:30 pm - 8:00 pm
Phoebe Stapleton (Rutgers University, United States)
"Nanomaterial Applications and Toxicities in Perinatal Therapeutics"
8:00 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
S. Rahima Benhabbour (University of North Carolina at Chapel Hill, United States)
"Harnessing Innovative Engineering Tools to Develop Next Generation Multipurpose Technologies for Prevention of HIV and Unplanned Pregnancy"
9:00 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Biomaterials-Drug Carrier Interface
Discussion Leader: Angela Alexander-Bryant (Clemson University, United States)
9:00 am - 9:30 am
Anita Shukla (Brown University, United States)
"Stimuli-Responsive Antimicrobial Drug Delivery Systems"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Benjamin Keselowsky (University of Florida, United States)
"Engineered Indoleamine 2,3-Dioxygenase for Immunometabolic Suppression of Inflammation"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Tejal Desai (Brown University, United States)
"Tuning the Biomaterial Interface for Immune Cell Engagement and Modulation"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Gregg Duncan (University of Maryland, United States)
"The ECM Barrier to Drug and Gene Delivery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunoengineering-Enabling Technology
Discussion Leader: Tatiana Novobrantseva (Moderna Therapeutics, United States)
7:30 pm - 7:55 pm
Carston Wagner (University of Minnesota, United States)
"Engineering Therapeutic Cell-Cell Interactions"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Kara Spiller (Drexel University, United States)
"Bionic Macrophages for Regenerative Medicine"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Susan Thomas (Georgia Institute of Technology, United States)
"Lymphatic Targeting Therapeutic Delivery Systems"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Next-Generation Nanoformulations
Discussion Leader: Anand Subramony (Eli Lilly and Company, United States)
9:00 am - 9:30 am
Justin Hanes (Johns Hopkins School of Medicine, United States)
"Nanomaterials for Gene and Drug Delivery through Mucus"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Matthew Francis (University of California, Berkeley, United States)
"Modified Viral Capsids for Applications in Drug Delivery"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Elizabeth Nance (University of Washington, United States)
"Engineering to Maximize Transport: Nanotherapeutics for the Developing Brain"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Samir El Andaloussi (Karolinska Institutet, Sweden)
"Engineered Extracellular Vesicles for Targeted Delivery of RNA and Gene Editors"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Selected Poster Presentations
Discussion Leaders: Theresa Reineke (University of Minnesota, United States) and Natalie Artzi (Brigham and Women's Hospital / Harvard Medical School / Massachusetts Institute of Technology, United States)
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Short Talk Selected from Poster Abstracts
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Precision Delivery Systems: Targeting Cells and Tissues
Discussion Leader: Samir Mitragotri (Harvard University, United States)
9:00 am - 9:30 am
Daniel Siegwart (University of Texas Southwestern Medical Center, United States)
"Development of Selective Organ Targeting (SORT) Lipid Nanoparticles (LNPs) and Signal Peptide Engineered Nucleic Acid Design (SEND) for Treatment of Disease-Causing Mutations"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Patrick Stayton (University of Washington, United States)
"Polymeric Prodrugs For Infectious Disease and Immune Therapy"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 12:00 pm
Sarah DeVos (Denali Therapeutics, United States)
"Transporting Oligonucleotides Across the Blood Brain Barrier Using the Transferrin Receptor"
12:00 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Drug Carrier Design for Imaging and Theranostics
Discussion Leader: Sujatha Sonti (GlaxoSmithKline, United States)
7:30 pm - 7:55 pm
Agata Exner (Case Western Reserve University School of Medicine , United States)
"Ultrasound-Mediated Drug-free Theranostics for Treatment of Prostate Cancer"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Markita Landry (University of California, Berkeley, United States)
"Protein Corona Formation on Lipid Nanoparticles and Implications for Nanoparticle Cellular Entry Kinetics"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
David Ulmert (University of California, Los Angeles, United States)
"Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy Resistance"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure