| SUNDAY | 
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) | 
| 6:00 pm | Dinner | 
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff | 
| 7:40 pm - 9:30 pm | ADME Sciences at the Center of Drug Research: Making Better New Drugs and Using Old Drugs Better | 
|  | Discussion Leader: R. Scott Obach (Pfizer) | 
| 7:40 pm - 7:50 pm | R. Scott Obach (Pfizer) "ADME Sciences at the Center of Drug Research: Making Better New Drugs and Using Old Drugs Better"
 | 
| 7:50 pm - 9:00 pm | Keynote Speaker: Yuichi Sugiyama (U. Tokyo) "Drug Transporters: Roles in New Drug Discovery and Development"
 | 
| 9:00 pm - 9:30 pm | Discussion | 
| MONDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 8:30 am | Group Photo | 
| 9:00 am - 12:30 pm | ADME Sciences and Pharmacology | 
|  | Discussion Leader: Lisa Benincosa (Roche) | 
| 9:00 am - 9:30 am | Don Mager (U. Buffalo) "Bridging PK/PD and Systems Pharmacology Modeling in Oncology"
 | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Megan A. Gibbs (Amgen) "Quantitative Pharmacology in the Discovery Space:  Modeling and Simulation Challenges for Biologics"
 | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am | Coffee Break | 
| 11:00 am - 11:30 am | Neil Parrott (Roche) "Physiologically based pharmacokinetic models for small molecules and biologics"
 | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | Alison Betts (Pfizer) "Optimizing design and translational strategy of antibody drug conjugates through PK/PD and systems pharmacology modeling: challenges and opportunities"
 | 
| 12:15 pm - 12:30 pm | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | ADME Sciences and Toxicology | 
|  | Discussion Leader: Jack Uetrecht (U. Toronto) | 
| 7:30 pm - 8:00 pm | Cynthia Ju (U. Colorado) "Animal Models of Adverse Drug Reactions"
 | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Gerry Kenna (AstraZeneca) "Implications of drug transporters and drug transporter interactions for drug safety"
 | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Dean Naisbitt (U. Liverpool) "Should the hapten hypothesis be used in 2011 to define the chemical basis of immune-mediated idiosyncratic drug toxicity"
 | 
| 9:20 pm - 9:30 pm | Discussion | 
| TUESDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | ADME Sciences and Clinical Pharmacology Part 1: Modelling and Prediction | 
|  | Discussion Leader: Heidi Einolf (Novartis) | 
| 9:00 am - 9:30 am | Hartmut Derendorf (U. Florida) "How to handle protein binding in modeling and simulation"
 | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Aleksandra Galetin (U. Manchester) "Role of PBPK modelling in the assessment of transporter-mediated drug-drug interactions"
 | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am | Coffee Break | 
| 11:00 am - 11:30 am | Jenny Chien (Eli Lilly) "Translational Science of Human Pharmacokinetics: Common Methodologies and Case Examples"
 | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | Hiroyuki Kusuhara (U. Tokyo) "Importance of drug transport in clinical PK or target effects"
 | 
| 12:15 pm - 12:30 pm | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | ADME Sciences and Clinical Pharmacology Part 2: Special Populations | 
|  | Discussion Leader: J. Steven Leeder (Children's Mercy Hospital, Kansas City) | 
| 7:30 pm - 8:00 pm | Yvonne Lin (U. Washington) "Identifying CYP2D6 Endogenous Biomarkers using Metabolomics"
 | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Xiaobo Zhong (U. Kansas Medical Center) "Developmental expression of CYP3A4 mRNA isoforms in hepatocyte maturation, pediatric and adult liver"
 | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Amin Rostami-Hodjegan (U. Manchester) "In the verge of impossibility: Studying new drugs for infinite permutations of special populations"
 | 
| 9:20 pm - 9:30 pm | Discussion | 
| WEDNESDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | ADME Sciences and Pharmaceutics | 
|  | Discussion Leader: Mitchell Taub (Boehringer-Ingelheim) | 
| 9:00 am - 9:30 am | Wei-Chiang Shen (U. Southern California) "Pharmacokinetics of Recombinant Bifunctional Fusion Proteins"
 | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Tom Raub (Eli Lilly) "Use of Iterative In Silico-In Vitro-In Vivo Learning Cycles to Optimize Brain Exposure"
 | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am | Coffee Break | 
| 11:00 am - 11:30 am | Urban Fagerholm (AstraZeneca) "PK-Matrix: A permeability- and CLint-based reference system for prediction, classification and profiling of human PK"
 | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | Yelena Kovtun (ImmunoGen) "Designing a perfect antibody-drug conjugate for anti-cancer therapy"
 | 
| 12:15 pm - 12:30 pm | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:00 pm - 7:30 pm | Business Meeting | 
|  | Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair | 
| 7:30 pm - 9:30 pm | Graduate Student and Post-Doc Presentations | 
|  | Discussion Leader: Henry Strobel (U. Texas-Houston) | 
| 7:30 pm - 7:45 pm | Mohamad  Elmeliegy (St. Jude's Children's Research Hospital) "Tumor Penetration and Cytotoxicity Studies of a Novel PDGFR Inhibitor, Crenolanib, in High-grade Glioma Models"
 | 
| 7:45 pm - 7:50 pm | Discussion | 
| 7:50 pm - 8:05 pm | Imir Metushi (U. Toronto) "Development of an Animal Model of Isoniazid-Induced Liver Injury"
 | 
| 8:05 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:25 pm | Karelle Menochet  (U. Manchester) "Simultaneous mechanistic modelling of active uptake and metabolism of repaglinide in rat hepatocytes"
 | 
| 8:25 pm - 8:30 pm | Discussion | 
| 8:30 pm - 8:45 pm | Zhican Wang  (U. Washington) "Dysregulation of Vitamin D Catabolism by CYP3A4 Induction: A Possible Mechanism of Drug-Induced Osteomalacia"
 | 
| 8:45 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:05 pm | Xiaohai  Li (Scripps Research Institute) "Discovery of the first highly selective CYP3A4 vs. CYP3A5 substrate and inhibitors - A focused screening and medicinal chemistry effort"
 | 
| 9:05 pm - 9:10 pm | Discussion | 
| 9:10 pm - 9:25 pm | Alex Morgan  (U. Western Ontario) "Quantitative in vitro to in vivo prediction of P-glycoprotein-mediated drug transport"
 | 
| 9:25 pm - 9:30 pm | Discussion | 
	
| THURSDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | ADME Sciences and Medicinal Chemistry | 
|  | Discussion Leader: J. Scott Daniels (Vanderbilt U.) | 
| 9:00 am - 9:30 am | Deepak Dalvie (Pfizer) "Role of non-P450 enzymes in drug metabolism: Emerging importance of aldehyde oxidase in drug discovery and lead optimization"
 | 
| 9:30 am - 9:45 am | Discussion | 
| 9:45 am - 10:15 am | Jan Wahlstrom (Amgen) "Structure-Based Modulation of DDI: From Chemotype to the Clinic"
 | 
| 10:15 am - 10:30 am | Discussion | 
| 10:30 am | Coffee Break | 
| 11:00 am - 11:30 am | Nigel Waters (Novartis) "Multi-Parametric ADME Optimization in Drug Discovery via Chemometrics and in silico Modeling"
 | 
| 11:30 am - 11:45 am | Discussion | 
| 11:45 am - 12:15 pm | Michael Cameron (Scripps-Florida) "Generation of reactive metabolites: 'This drug has the same chemical moiety and is well tolerated'"
 | 
| 12:15 pm - 12:30 pm | Discussion | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | New Ideas and Technologies | 
|  | Discussion Leader: Chandra Prakash (BiogenIdec) | 
| 7:30 pm - 8:00 pm | Andrew Parkinson (Xenotech, LLC) "Lysosomal trapping: methods of investigation, pharmacokinetic consequences and toxicological implications"
 | 
| 8:00 pm - 8:10 pm | Discussion | 
| 8:10 pm - 8:40 pm | Tonika Bohnert (Biogen Idec) "Evaluation of Chimeric Mice with Humanized Liver to Predict Human Intrinsic Clearance of Drug Molecules at Preclinical Phase"
 | 
| 8:40 pm - 8:50 pm | Discussion | 
| 8:50 pm - 9:20 pm | Jonathan Josephs (Bristol Myers Squibb) "Quan/Qual Experiments by Means of High Resolution Full Scan Accurate Mass - The Future of Discovery DMPK?"
 | 
| 9:20 pm - 9:30 pm | Discussion | 
| FRIDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am | Departure |