The 49th Drug Metabolism Gordon Research Conference will focus on cutting edge research in ADME (absorption, distribution, metabolism, elimination) science. The field of drug metabolism has always had a keen eye towards the conduct of translational science, i.e., the application of basic research findings towards impacting clinical practice. Whereas early drug metabolism researchers were limited in the methods available for translation of in vitro ADME findings, today’s researchers have a much broader toolkit available. This conference will cover new development in vitro tools and the methods available for translation. The 2019 conference will include a keynote presentation on translational models for drug induced liver injury, and scientific sessions on new models for predicting human PK, PK/PD and efficacious dose, drug and other xenobiotic DDIs, translational biomarkers for transporter function and toxicity, recent developments in predictive toxicology, understanding hydrolases for clinical outcomes and recent case studies in drug metabolism. All presentations will include unpublished data, with sessions designed for maximal audience discussion. Attendees are encouraged to submit posters for display at the poster sessions organized by the Vice Chair Dr. Steve Leeder. The Wednesday evening session will feature oral presentations by young investigators (graduate students and postdoctoral trainees) selected from the submitted poster abstracts. The conference is collegial and informal in nature, with ample opportunity to discuss unpublished research, make collaborative connections, and develop new ideas. Young investigators have easy access to mentoring from established investigators, as well as during informal career advice discussions planned during the week.
The registration fee includes all meals and housing on the Holderness School campus. In addition to the scientific sessions, attendees are encouraged to enjoy the many outdoor recreational activities in the area. Afternoon traditions of this conference include an Academia vs. Industry softball game (no experience necessary, bring your gloves!), and hiking and kayaking/canoeing outings in the White Mountains.
The conference will consist of nine sessions, on the topics listed below. The conference chair is currently developing their preliminary program, which will include the names of the invited speakers and discussion leaders for each of these sessions. The preliminary program will be available by October 15, 2018. Please check back for updates.
- Keynote Session: Translational Models for Drug-Induced Liver Injury
- New Models for Predicting Human PK
- Predicting Human PK, PK/PD and Efficacious Dose
- Translational Approaches to Untangle DDI Mechanisms and Improve Pharmacotherapy
- Translational Biomarkers for Transporter Function and Toxicity
- Predictive Models for Liver and Kidney Toxicity
- Young Investigator Presentations
- Understanding Hydrolases for Clinical Outcomes
- The Importance of Understanding Metabolite Profiles