Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Drug Development Evolution: Models to MPS and AI
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:35 pm
"New Approach Methodologies (NAMs) to Predict Transporter-Based ADME Including Tissue Drug Exposure"
8:35 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"History of DMPK: From Bench Chemistry to Complex in Vitro and in Silico Models"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Artificial Intelligence (AI) in Drug Metabolism and Clinical Pharmacology
9:00 am - 9:30 am
"Lab Bench-to-Cloud Pharmacology: Turning Organ-on-Chip Evidence into Deployable Predictive Models"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Artificial Intelligence in Clinical Pharmacology: Illustrative Case Studies"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Integrated AI Approach to Predict Drug-Drug Interactions Associated to Drug Metabolizing Enzymes"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Machine Learning–Enabled Prediction of Human Pharmacokinetics for Early Drug Discovery"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Implementation of New Approach Methodologies (NAMs) in Drug Development
7:30 pm - 7:55 pm
"Organoid Breakthrough: Advancements in Generating Organ-Specific Physiologically-Relevant Models"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Microfluidic PKPD: Accelerating Design Through Early Translation"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Current and Future Prospects for Complex In Vitro Models to Reduce or Replace Animal ADME Studies"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transporter Science: Biomarkers, Proteomics, and Modeling
9:00 am - 9:30 am
"Transporter Spatiotemporal Dynamics in the gut: Still a lot to Digest"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"AI-Driven Prediction of Drug Transporter Interactions: Models, Validation, and Practical Challenges"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"From Bench to Browser: A Web-Based PBPK Platform Integrating Placental Transporter Mechanisms to Predict Maternal-Fetal Drug Disposition"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Circulating Biomarkers for Transporters"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Science Behind Small Molecule Long-Acting Injectable (LAI) Therapeutics
7:30 pm - 7:45 pm
"Lenacapavir, An Exemplary Long-Acting Injectable Molecule:Pharmacokinetic Considerations"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
"Injection Site Tolerability Considerations for Development for Lenacapavir"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Lessons Learned During Ongoing Development of Long-Acting Products for Tuberculosis and Viral Hepatitis"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Long-Acting Injectables: Clinical Benefits, General Principles and Applications of Aqueous Suspension Formulations"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Technologies in Clinical Pharmacology
9:00 am - 9:30 am
"Integrated Approaches to Decoding Complex Drug–Drug Interactions Involving Transporters and Enzymes"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Genetic Variants in Drug Disposition Genes Dictate the Extent of Drug-Drug Interactions"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"A Risk-Based Approach to Therapeutic Peptide Drug Development : When to Consider Drug-Drug Interaction Studies"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Cannabinoid-Drug Interactions: Weeding New Inroads Using a Modeling and Simulation Approach"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Short Talks Selected from Poster Abstracts
7:30 pm - 7:45 pm
Short Talk Selected from Poster Abstracts
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Short Talk Selected from Poster Abstracts
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Short Talk Selected from Poster Abstracts
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Short Talk Selected from Poster Abstracts
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Beyond Xenobiotics: Endogenous Roles for Drug Metabolizing Enzymes and Transporters
9:00 am - 9:30 am
"Decoding the Toxico-Metagenome: Implications for Xenobiotic Metabolism and Human Disease"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Role of ABCG2 in Protoporphyrin IX Disposition and Toxicity"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Microbial AHR Ligands as Drivers of Colon Cancer Progression"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Design and Characterization of Probe Substrates of 17β-Hydroxysteroid Dehydrogenase 13"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Patient-Centric Pharmacokinetics and Pharmacodynamics in Specific Populations
7:30 pm - 7:55 pm
"From Virtual Trials to Virtual Twins: Motivation to Take on Cracks Knowing We May See Bigger Gaps!"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Unleashing the Power of Quantitative Systems Pharmacology Modeling to Inform Drug Development"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Ex-vivo to In-vivo Extrapolation: A Translational Framework for Extracorporeal Clinical Pharmacology"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure