| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Future Challenges of Drug Safety Research |
| Discussion Leader: Peter Loskill (Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Germany) |
| 3:45 pm - 4:25 pm | Teresa Woodruff (Northwestern University, USA)
"Building the Tools that Solve Emerging Problems that Create New Fields: It's No Longer Bench to Paper to Grant and Back!" |
| 4:25 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | In Vitro Tissue Model Systems for the Prediction of Toxicity |
| Discussion Leader: Stephanie Dauth (Harvard University, USA) |
| 7:30 pm - 7:45 pm | Marie-Elena Brett (University of Minnesota, USA)
"High Throughput 3D Cell Culture Platform for Drug Development" |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Yimu Zhao (University of Toronto, Canada)
"Biowire II: Drug Testing Platform Using Matured Human Engineered Cardiac Tissue" |
| 8:05 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Nathaniel Huebsch (Gladstone Institute of Cardiovascular Disease, UCSF, USA)
"Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Johan Lind (Harvard University, USA)
"Higher Throughput Instrumented Cardiac Organs-on-Chip Devices" |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Marko Groeger (Jena University Hospital, Germany)
"Microfluidically Supported Organoids for Modelling Systemic Inflammation" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Ilka Maschmeyer (TissUse, Germany)
"Multi-Organ-Chip Developments: Towards a Paradigm Shift in Drug Development" |
| 9:25 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Computational Drug Safety / Pharmacogenomics and Patient Tailored Drug Safety |
| Discussion Leaders: Troy Hawkins (Eli Lilly and Company / Elanco Animal Health, USA) and Katie White (Vanderbilt University, USA) |
| 9:00 am - 9:15 am | Eric Watt (U.S. Environmental Protection Agency, USA)
"Uncertainty Quantification in High Throughput Screening: Applications to Models of Endocrine Disruption, Cytotoxicity, and Zebrafish Development" |
| 9:15 am - 9:20 am | Discussion |
| 9:20 am - 9:35 am | Tal Lorberbaum (Columbia University, USA)
"Discovering New Drug-Drug Interactions Using Data Science and Systems Pharmacology: Applications to Drug-Induced Long QT Syndrome" |
| 9:35 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Takaya Moriyama (St. Jude Children's Research Hospital, USA)
"NUDT15 Polymorphisms and Thiopurine Treatment Individualization in Children with Acute Lymphoblastic Leukemia (ALL)" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:15 am | Natalie Holman (Hamner-UNC Institute for Drug Safety Sciences, USA)
"Hepatocyte-Derived Exosomes: Early Mediators of Drug-Induced Liver Injury?" |
| 10:15 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Julia Tobacyk (University of Arkansas for Medical Sciences, USA)
"Population Variability in Cisplatin-Induced Kidney Injury Outcomes Are Modeled Using Diversity Outbred Mice" |
| 10:35 am - 10:40 am | Discussion |
| 10:40 am - 10:55 am | Laura Wiley (Vanderbilt University, USA)
"Strategies for Equitable Pharmacogenomic-Guided Warfarin Dosing Among European and African American Individuals in a Clinical Population" |
| 10:55 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Career Panel |
| Discussion Leader: Rowena Sison-Young (University of Liverpool, United Kingdom) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Getting the Foot in the Door: First Steps on the Way to a Job in Academia, Industry or Governmental Institutions" |
|
- Robert Chapin (Pfizer Global Research and Development, USA)
- Myrtle Davis (National Cancer Institute, NIH, USA)
- Kristin Fabre (AstraZeneca, USA)
- Gunaretnam Rajagopal (Janssen R&D, USA)
- Teresa Woodruff (Northwestern University, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
