Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Biology of Tissue Elasticity
7:40 pm - 8:00 pm
"Full Atomistic Modeling of Tropoelastin Structure, Dynamics and Mechanics, and Upscaling to Elastic Fibers"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Tropoelastin and Multifunctional Biology"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Molecular-Scale Details of Elastin's Complex and Dynamic Structure"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Elastin in Central Artery Health and Disease"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Extracellular
Modulation of Cell Signaling
9:00 am - 9:20 am
"Latent TGFbeta Binding Protein 4 as a Muscle Disease Modulator"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"LTBP1 a Pro-Invasive Factor in Breast Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Fibulin-4a Enhances Vascular and Inhibits Cardiac Progenitor Fate in the Lateral Plate Mesoderm by Inhibiting TGFbeta Signaling"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"New Mechanisms of BMP Activation Within the Fibrillin Scaffold"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Partitioned Signaling Strategies of Angiotensin Receptor Blockade in Emphysema"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"ADAMTS1 and Nitric Oxide as New Mediators of Aortic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enabling Technologies for
Elastic Fiber Research
7:30 pm - 7:40 pm
"Hierarchical Organisation of Fibrillin from Tissue Structure to Microfibrils"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:05 pm
"Structural Studies of Elastin by NMR - From Monomers to Coacervates"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Imaging the Arterial Wall: Fluorescence and NanoCT Imaging"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Marker-Free Screening of Elastic Fibers and Associated Proteins"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Use of Genome Editing to Study the Effects of Misfolding Mutants in Fibrillin-1 Domain TB4"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Functional Modifiers of Elastic Fibers
9:00 am - 9:20 am
"Insights into LOXL2 Structure and Vascular Matrix Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lysyl Oxidase Mutations in Vascular Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Congenital Contractural Arachnodactyly (CCA) Inherited as an Autosomal Recessive Marfanoid Disorder Is Associated with a ~58kbp Deletion in the ADAMTSL3 Gene"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"ADAMTS10 Mediated Tissue Disruption in Weill Marchesani Syndrome"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Limb- and Tendon-Specific Deletion of ADAMTSL2 Results in a Short-Limb Phenotype Mimicking Geleophysic Dysplasia"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Role of ADAMTSL6beta on the Aortic Aneurysm and Dissection in Marfan Syndrome Mouse Model"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Essential Function of Fibulin-4 in Lysyl Oxidase Activation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Elastic Fiber Assembly and Composition
7:30 pm - 7:50 pm
"What Are Elastic Tissues Made of: A New Approach to Defining Tissue Proteomes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Subcutaneous Tissue Regulates the Condition of Dermal Layer Matrix via Secretion of Multiple Factors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Plasma Fibronectin Acts as a Safeguard in the Vasculature and Supports Synergistic and Differential Roles with Cellular Fibronectin in Vascular Matrix Integrity"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Insulin Resistance Induced by Elastin Fragmentation Promotes Endothelial Impairment and Arterial Hypertension"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"The Role of Thrombospondin-1 in Mechanosensing of the Aortic Wall"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Elastic Tissue
Regeneration and Translational Approaches
9:00 am - 9:20 am
"Engineering Highly Elastic Surgical Sealants"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Arterial Regeneration in Aged Animals"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Interplay of Order and Disorder Controls Hierarchical Self-Assembly of Partially Structured Elastin Polypeptides"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"A New Member of Chimeric Polypeptide Family Inspired by Elastin-Like Sequences for Tissue Engineering Applications"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Tubular Scaffolds with Shape Recovery Resulting in Radial Elasticity"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Three Dimensional Fabrication of Vasculature with Tropoelastin"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"JNK-Targeting Nanotherapeutics for Elastic Matrix Regenerative Repair in Abdominal Aortic Aneurysms"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Microfibrillar Proteins and Metabolic Function
7:30 pm - 7:50 pm
"Asprosin, a Fasting-Induced Glucogenic and Orexigenic Protein Hormone"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Comparing Fibrillin-1 and MAGP1's Role in Metabolic Health"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Circulating Fibrillin Fragments in Health and Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"LTBP-4 Structure and Function Is Guided by Fibulin-4"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fibrillinopathies
and Elastin-Related Diseases
9:00 am - 9:20 am
"Novel Genes and Mechanisms for Thoracic Aortic Dissections"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Modeling Marfan Aortic Abnormalities In Vitro Using Induced Pluripotent Stem Cells"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Systems Pharmacology Approaches Identify Novel Pathways of Arterial Disease in Mice with Marfan Syndrome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"End Organ Effects of Elastin Insufficiency"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"RAGE/sRAGE Axis: Novel Biomarker and Mechanism of Thoracic Aortic Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"SMC TGF-β Signaling in Aortic Homeostasis and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lung and
Vasculature Development, Homeostasis and Disease
7:30 pm - 7:50 pm
"Autoimmune Mediated Elastin Degradation: Insights from Human Disease and Animal Models"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Developmental Underpinnings of Aneurysmal Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mutations in Fibulins and LOX Influence Vessel Mechanics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Conditional Deletion of Rcan1 Promotes Aortic Intramural Hematoma that Progresses to Abdominal Aortic Aneurysm"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure