Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Elastin Structure and Biology: A Macro View
7:40 pm - 8:00 pm
"Tropoelastin Structure and Assembly"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Structural and Mechanical Hierarchies in Arterial Elastin"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Elastic Fibers in Muscular Arteries: Structure, Function and Changes with Age"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Elastin-Like Recombinamers and Antimicrobial Peptides: Self-Assembly"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Differential Cell-Matrix Mechanoadaptations Drive Regional Propensities to Aortic Fibrosis, Aneurysms or Dissection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Raman Imaging of Elastic Fibers and Microfibrils"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Fibrillin Structure-Function in Elastic Tissues"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Characterization of Elastin-Inspired Scaffolds"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"4D Ultrasound Reveals Correlation Between Strain Reduction and Elastin Degradation in Dissecting Murine Abdominal Aortic Aneurysms"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Crosslinked Elastin-Like Polypeptide (ELP) Membranes as a Model for Arterial Vascular Calcification"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Aortic Aging: Calcification and Stiffness
7:30 pm - 7:50 pm
"The Role of Inflammation in Aortic Stiffening"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Matrix Regulation of Arterial Stiffness and Aging Calcification"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Delineating the Mechanisms Underlying Rare Disorders of Ectopic Calcification to Reveal Novel Therapeutic Strategies"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Self-Assembled Silk-Elastin-Like Co-Recombinamer into Spherical Microparticles"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Stabilization and Restoration of Elastin in Cardiovascular and Lung Diseases by Nanomedicine Therapies"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Genetic Interrogation of Thoracic Aneurysms"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanistic Basis for Regional Predisposition to Aneurysm"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"TGF-Beta Signaling in SMC"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"BMP Driven Mechanisms in Aortic Aneurysm Formation Caused by Fibrillin-1 Deficiency"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Modelling Aortopathies Using Human iPS Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Role of Stem Cell Derived Extracellular Nanovesicles in Augmenting Elastic Matrix Regenerative Repair for AAA Treatment"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Multiple Rare Inherited Human LRP1 Variants Associated with Aortic Disease Impair LRP1 Processing and/or Maturation In Vitro "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Fluoroquinolones Promote Degeneration of the Aortic Extracellular Matrix"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Modeling Marfan Syndrome in the Mouse Eye"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Zebrafish Models of Genetic Elastic Fiber Disorders"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"MicroRNAs in Aortic Aneurysm Formation Associated with Marfan Syndrome"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Pharmacological Inhibition of Notch Signaling Attenuates the Progression of Active Abdominal Aortic Aneurysm"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Elastin-Associated Matrix Changes and Tissue Integrity
9:00 am - 9:20 am
"Point Mutations in Lysyl Oxidase Cause Aortic Dilation Modified by Genetic and Environmental Influences"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Notch-Mediated Hypermuscularization in Elastin Aortopathy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"An HDAC9-MALT1-BRG1 Complex Mediates Smooth Muscle Dysfunction in Diverse Vascular Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Contribution of Matrix Mechanotransduction in Vascular Remodeling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Novel O-Glucosylation of EGF Repeats in Notch and Fibrillins"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Human and Mouse Genomic Studies Point to Extracellular Matrix and Immune Pathways as Modifiers of Cardiovascular Phenotype Severity in Williams Beuren Syndrome"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Fibrillin-1 Hypomorphic Mouse Aortas Are Sexually Dimorphic, but Neither Sex Responds to Renin-Angiotensin Systemic Inhibitors During the Progression Phase of Aortic Aneurysm"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Fibrillinopathies: Metabolism, Modifiers and In Vitro Models
7:30 pm - 7:50 pm
"Roles for Matricellular Proteins in Elastic Fiber Development and Regeneration"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"ADAMTS Proteins and Regulation of Microfibril Composition"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Substrates for the ADAMTS17 Protease and Their Role in ECM Formation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"The Effect of Translational Read-Through Drugs on Fibrillin-1 Deposition in Marfan Syndrome Patient-Derived Fibroblasts Harboring a Stop-Codon Mutations in FBN1"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Neutrophilic Inflammation Disrupts Elastic Fiber Assembly in the Saccular Stage Lung"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Elastin in Pulmonary and Vascular Pathologies
9:00 am - 9:20 am
"Lysyl Oxidase Mutations, Inflammation and Vascular Wall Integrity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Contributions of Fibulin-4 and Lysyl Oxidase to Large Versus Small Vessels"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Tropoelastin Modulates Mesenchymal Stem Cell Performance"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Crosstalk Between Matrix, Fibroblasts and Macrophages in Remodeling Processes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Crosstalk Between Macrophage and Vascular Smooth Muscle Cells Promotes Elastin Degradation in Aortic Aneurysms"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Elastin-Secreting Vascular Smooth Muscle Cells Derived from Human Induced Pluripotent Stem Cells"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mechanistic and Therapeutic Interrogation of Novel Mouse Models of Vascular Ehlers-Danlos Syndrome"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Functional Modifiers of Elastic Tissues
7:30 pm - 7:50 pm
"Fibrillin-1 Regulation of Adipose Tissues"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"C-Terminally Truncated Fibrillin-1 Protein Causes Marfanoid Progeroid Lipodystrophy Syndrome in Mice"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Asprosin, Its Receptor and Metabolic Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"A Novel Role for LRP1 in Vessel Wall Homeostasis: Insight from a Rare Genetic Variant"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Functional Elastic Fibers Are Necessary for Mechanical Integrity of Tendon: Insights from Elastin Haploinsufficient and Fibulin-5 Knockout Murine Models"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure