Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Specific Functions of Endothelial Cells |
| Discussion Leader: Victoria Bautch (The University of North Carolina at Chapel Hill, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 8:30 pm | Laura Niklason (Yale University, USA) "Endothelial Cells and Tissue Engineering" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:20 pm | Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany) "New Leaves on the Vascular Tree: Organ-Specific Functions of the Endothelium" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Organ-Specific Endothelial Cell Phenotypes |
| Discussion Leader: Timothy Hla (Weill Cornell Medicine, USA) |
9:00 am - 9:20 am | Richard Daneman (University of California, San Diego, USA) "Blood-Brain Barrier Formation and Function" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Steven George (Washington University in St. Louis, USA) "iPS-Derived Endothelial Cells and 'Organ-on-a-Chip' Technology" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Asrar Malik (University of Illinois at Chicago, USA) "Tension Landscape at Adherens Junctions Regulated by VE-Cadherin and VE-PTP" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Mariona Graupera (IDIBELL, Spain) "Stimulating Vessel Growth Prevents White Adipose Tissue Expansion" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Eugene Butcher (Stanford University, USA) "Endothelial Cell Progenitors, High Endothelial Venules and the Immune Response" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Marta Segarra (Goethe University Frankfurt, Germany) "Reelin Regulates Developmental Angiogenesis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Mara Pitulescu (Max Planck Institute for Molecular Biomedicine, Germany) "Coupling of Sprouting Angiogenesis and Artery Formation" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Karina Yaniv (Weizmann Institute of Science, Israel) "Building Blood and Lymphatic Vessels in Vertebrates: Insights from Zebrafish" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Endothelial Origins and Multi-Potentiality |
| Discussion Leader: Susan Quaggin (Northwestern University, USA) |
6:00 pm - 6:20 pm | Karen Hirschi (Yale School of Medicine, USA) "How Endothelial Cells Make Blood" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Mervin Yoder (University of Indiana School of Medicine, USA) "Evidence that Circulating Endothelial Colony-Forming Units Are Derived from Vascular Endothelium" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Austin McDonald (University of California, Los Angeles, USA) "Mechanisms of Arterial Lining Regeneration In Vivo" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Ferdinand Le Noble (Karlsruhe Institute of Technology (KIT), Germany) "Neuronal Flt1 Controls Spinal Cord Vascularization via Venularized Arterial Endothelium" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Kristy Red-Horse (Stanford University, USA) "Alternative Progenitors Provide Robustness to Vascular Development" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Vessel Phenotypes in Disease |
| Discussion Leader: Jan Kitajewski (University of Illinois at Chicago, USA) |
9:00 am - 9:20 am | Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland) "Dural Lymphatic Vessels and Disease" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | William Muller (Northwestern University, USA) "Endothelial Cell Regulation of Trans-Endothelial Migration" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Erich Kushner (University of North Carolina at Chapel Hill, USA) "Tumor-Related Centrosome Over-Amplification Perturbs EC Anisotropy During Angiogenesis" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Sudarshan Anand (Knight Cancer Institute, Oregon Health and Science University, USA) "MicroRNA Regulation of Endothelial DNA Repair Inhibits Angiogenesis" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Andreas Fischer (German Cancer Research Center, Germany) "Endothelial Notch 1 Activity Facilitates Metastasis" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:25 am | Andrew Dudley (University of North Carolina at Chapel Hill, USA) "A TGFβ-Regulated miRNA that Coordinates Vascular-Directed Fibrinolysis and Angiogenesis" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Noo Li Jeon (Seoul National University, South Korea) "Engineering Blood and Lymphatic Vessels In Vitro" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Christopher Chen (Boston University / Harvard University, USA) "Nanofabrication and Mechanisms of Tissue Vascularization" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Lymphatics - Heterogeneous Origins and Functions |
| Discussion Leader: Karen Hirschi (Yale School of Medicine, USA) |
6:00 pm - 6:20 pm | Taija Makinen (Uppsala University, Sweden) "Heterogeneity in the Lymphatic Vascular System and Its Origin" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland) "Role of Flow and Heterogeneity in Lymphatic Valve Formation" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Annalisa Zecchin (Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center (VRC), Belgium) "Role of Fatty Acid β-Oxidation in Lymphangiogenesis" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | S. Ananth Karumanchi (Beth Israel Deaconess Medical Center, USA) "Novel Therapy for Preeclampsia" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Susan Quaggin (Northwestern University, USA) "Functions of Lymphatic Vasculature" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Vessels and Regenerative Medicine |
| Discussion Leader: S. Ananth Karumanchi (Beth Israel Deaconess Medical Center, USA) |
9:00 am - 9:20 am | Roger Kamm (Massachusetts Institute of Technology, USA) "Vascularized Models for Metastatic Cancer" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Shulamit Levenberg (Technion - Israel Institute of Technology, Israel) "Vascularization of Engineered Matrices" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Suk-Won Jin (Yale University, USA) "Regulation of Pro-Angiogenic BMP Signaling in EC" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Feilim Mac Gabhann (Johns Hopkins University, USA) "VEGF, ECM and Computational Models in Regenerative Medicine" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Eleni Tzima (University of Oxford, United Kingdom) "Mechanisms of Flow-Mediated Atherosclerosis" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Jan Kitajewski (University of Illinois at Chicago, USA) "Defining Notch Function in Pericytes Using New In Vitro and In Vivo Tools" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | John Chappell (Virginia Tech Carilion Research Institute, USA) "VEGF-A Modulates Pericyte-EC Interactions via Connexin 43" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Christopher Hughes (University of California, Irvine, USA) "Recreating Complex Vascularized Tissue Micro-Environments In Vitro" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Vasculature as a Stem Cell Niche |
| Discussion Leader: Asrar Malik (University of Illinois at Chicago, USA) |
6:00 pm - 6:20 pm | Eli Keshet (Hebrew University of Jerusalem, Israel) "VEGF and Stem Cell Niches" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Sharon Gerecht (Johns Hopkins University, USA) "Engineered Vessels and Stem Cells" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Shahin Rafii (Weill Cornell Medicine, USA) "Angiocrine Function of the Vascular Niche in Organ Regeneration Without Fibrosis" |
7:20 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Christiana Ruhrberg (University College London, United Kingdom) "Stem Cells in a Vascular Niche" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | EC Heterogeneity: Signaling and Mechanotransduction |
| Discussion Leader: Christopher Hughes (University of California, Irvine, USA) |
9:00 am - 9:20 am | Mark Kahn (University of Pennsylvania, USA) "Endothelial Signaling Aberrations in Cerebral Cavernous Malformation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Timothy Hla (Weill Cornell Medicine, USA) "SIPs, Lipids, and Inflammation" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Massimo Santoro (VIB Vesalius Research Center, KU Leuven, Belgium) "Hemodynamic Forces Activate Arterial Notch Signaling for Recruiting Vascular Mural Cells" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Arndt Siekmann (Max Planck Institute for Molecular Biomedicine, Germany) "Endoglin Controls Blood Vessel Diameter via EC Shape Changes in Response to Haemodynamic Cues" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Weilan Ye (Genentech Inc., USA) "LRP5 Antibodies Potentiate Norrin-Mediated Canonical Wnt Signaling in Retinal Disease" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Wiebke Herzog (University of Muenster, Germany) "Sema 3D Controls EC Migration by Guidance via PlexinD1 and Collective Migration Through NRP1" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Riikka Kivelä (Wihuri Research Institute / University of Helsinki, Finland) "Endothelial Cell to Cardiomyocyte Crosstalk Is Mediated via Endothelial VEGF-VEGFR2 Signalling" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Hanjoong Jo (Emory University, USA) "Flow, Epigenetics and Disease" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Keynote Session: Neurovascular Interactions in Translation |
| Discussion Leader: Ralf Adams (Max Planck Institute for Molecular Biomedicine, Germany) |
6:00 pm - 6:40 pm | Elisabetta Dejana (IFOM, FIRC Institute of Molecular Oncology, Italy) "Neurovascular Interactions and CCM" |
6:40 pm - 6:50 pm | Discussion |
6:50 pm - 7:10 pm | Yosuke Mukoyama (National Heart, Lung, and Blood Institute, NIH, USA) "Neurovascular Stem Cell Niches" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:40 pm | Chenghua Gu (Harvard Medical School, USA) "Neurovascular Congruency" |
7:40 pm - 7:50 pm | Discussion |
7:50 pm - 8:00 pm | Closing Remarks |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |