Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The Life Cycle of the Endothelium
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Genetic Compensation in Endothelial Health and Disease"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Endothelial Plasticity and Resilience Across Stress Responses and Aging"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Endothelial Death Pathways Regulating Microvascular Hemostasis"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Endothelial Cell Biology and Developmental Mechanisms
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Functional Roles for glycoRNAs in the Regulation of Endothelial Cells and Angiogenesis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Delineating the Pathways Regulating Angiogenesis from Different Endothelial Sources During Coronary Vessel Formation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Novel Roles for Endomucin, An Endothelial Glycocalyx Component, in Inflammation and Angiogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Degrading to Re-Grow: Harnessing Targeted Protein Degradation to Understand Principles of Vascular Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Diverse behaviours of Oncogenic Mutations in Endothelial Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Social Life of Endothelial Cells: Tissue-Specific Interactions in Health and Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Organ-Specific Endothelium
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Molecular Heterogeneity and Functional Specialization of Endothelial Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Pulmonary, Bronchial, and Lymphatic Vascular Remodeling in Pulmonary Hypertension"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Endocardial GPR126 senses mechanical stretch to maintain cardiac filling"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Distinctive Features and Specialized Physiology of Brain Endothelial Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Endothelial Heterogeneity and Resilience
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Cadherin-6 (Cdh6) -Dependent Endohtelial Cell Adhesion in Endocardium and Lymphatics of Zebrfish"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"From Force to Form: Integrins and Piezo1 Orchestrate Angiopoetin Signaling in the Vasculature"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"MCC Calibrates Endothelial Shear Sensitivity to Preserve Cerebrovascular Function and Cognition Under Chronic Hypoperfusion"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Defining the Vascular Niche of Human Adipose Tissue Across Metabolic States"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Development of Angiocrine-Based First-in-Class Therapeutics for Organ Fibrosis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Divergent Endothelial Phenotypes in Males and Females During Vascular Remodeling."
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Technologies in Endothelial Research
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Integrin-Independent Tie2 Activation Using de Novo Designed Proteins"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Unveiling the Mysteries of Vascular Development and Regeneration with Advanced Human Organoid Models"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Engineered Vasculature to Probe the Mechanoregulation Linking Forces, Structure, and Endothelial Function"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Modular Assembly of Arterial Organoids Enables Rapid Blood Perfusion to Ameliorate Ischemic Diseases"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Acute Diseases and Endothelial Pathophysiology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Mechanisms and Treatment of Vascular Complications of Preeclampsia"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Novel Approaches to Preserve Blood Brain Barrier Integrity and Promote Angiogenesis in Stroke"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Endothelial Mechanisms of Cognitive Dysfunction: Insights from Sepsis and Stroke"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Building and Breaking Barriers: 3D Blood-Brain Barrier Models for Cerebral Malaria Research"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Not All Clotting is Blood Clotting: Biology and Disease of Lymphothrombosis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chronic Diseases and Endothelial Pathophysiology
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Endothelial Mechanisms of Obesity Associated Diabetes"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Endothelial Immune Signaling in the Regulation of Cardiac Remodeling and Function"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Endothelial Regulation of Skeletal Muscle Hypertrophy"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Lymphatic Endothelium in Inflammation and Chronic Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Endothelial Cells in Oncology and Immunology
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Mechanisms of Endothelial Dysfunction in Systemic Autoimmune Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Distinct Lymphatic Endothelial Cell Subsets Define Mechanisms of Drainage in the Lung Lymphatic Vasculature"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Endothelial Control of Tumor Immunity and Metastasis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Endothelial Membrane Lipid Composition in Vascular Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Inflammatory Responses in Obesity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Neutrophil-Induced Local RNA Translation in Endothelial Cells Promotes CD8 T-cell Extravasation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Entrepreneurial Endothelial Science
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Endothelial Cell Research Driving Biotech Drug Discovery"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Serendipity in Science: From a Surprising Observation to a Therapeutic Antibody"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Characterization of a Distinct Endothelial Subtype in Subepidermal Capillaries and NG2+ Pericytes in the Context of Epidermal Formation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Molecular Determinants of Tissue-Specific Endothelial Cells for Building Vascularized Mini-Organs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure