| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Session: EDCs: What Does the Future Hold? |
| Discussion Leader: TBA |
| 7:40 pm - 8:20 pm | Scott Gilbert (Swarthmore University and U. Helsinki)
"The New Normal: Developing in the Technoestrogenic Niche"
|
| 8:20 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:15 pm | John Warner (Warner Babcock Institute for Green Chemistry)
"Green Chemistry Approaches to Endocrine Disruptor Free Products"
|
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Endocrine Disrupting Chemicals and Female Reproductive Health |
| 9:00 am - 9:05 am | Discussion Leader: John McLachlan (Tulane University)
"Introduction" |
| 9:05 am - 9:35 am | Sue Fenton (NIEHS)
"Lifelong Impact on the Female Reproductive System in Mice Prenatally Exposed to Perfluorooctanoic Acid"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Jessica LaRocca (Harvard University)
"Prenatal Endocrine Female Reproduction Disrupting Chemical Exposure Is Associated with Epigenetic Alterations in the Placenta"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:30 am - 11:00 am | Andreas Kortenkamp (Brunel University, London)
"Exposures to Xenoestrogens - Assessing the Magnitude of the Problem from a Mixture Perspective"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | John Sumpter (Brunel University, London)
"The Exquisite Sensitivity of Fish Reproduction to Steroid Hormones in the Aquatic Environment Both Singularly and in Combination"
|
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Cheryl Murphy (Michigan State University)
"Linking Upstream Neuroendocrine Disruption to the Hypothalamus-Pituitary-Gonadal Axis to Predict Adverse Effects on Fecundity Across Fish, Birds and Mammals" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | EDCs and Cancer |
| 6:00 pm - 6:10 pm | Discussion Leader: Les Reinlib (NIEHS)
"Introduction" |
| 6:10 pm - 6:40 pm | Ana Soto (Tufts University)
"Fetal Exposure to BPA and Adult Mammary Cancer"
|
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:20 pm | Susan Teitelbaum (Mt. Sinai School of Medicine, NY)
"Exposures to EDC Mixtures During Critical Developmental Windows and Breast Cancer Outcomes"
|
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 7:50 pm | Jerome Hershman (UCLA School of Medicine)
"Environmental Toxins Cause Double Strand DNA Breaks in Thyroid Cells that Could Lead to Oncogenic Mutations Resulting in Thyroid Cancer"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Male Reproductive Health |
| 9:00 am - 9:05 am | Discussion Leader: Andreas Kortenkamp (Brunel University)
"Introduction" |
| 9:05 am - 9:35 am | Alex Burdorf (Erasmus University, NL)
"Associations of Maternal Exposure to Mixtures of EDC with Cryptorchidism and Hypospadias in Offspring"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Karma Fussell (BASF SE)
"Testing Mixtures of Endocrine Disruptors In Vivo at Human-Relevant Exposure Levels"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:30 am - 11:00 am | David Møbjerg Kristensen (University of Copenhagen)
"Towards an Understanding of the Endocrine Disturbance by Mild Analgesics"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Donald Tillett (USGS)
"Mechanisms of Feminisation in Fish"
|
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Elizabeth Hill (University of Sussex, UK)
"Effect-Directed Analyses with Human and Fish Tissue Material Reveals Totally New Chemical Exposures"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Discourse on the Value of Model Systems to Predict EDC Effects on the Perinatal Human |
| 6:00 pm - 6:10 pm | Discussion Leader: Bruce Blumberg (U. C. Irvine, USA)
"Introduction" |
| 6:10 pm - 6:40 pm | Bernard Jegou (INSERM, France)
"The Importance of Animal Models to Predict Human Effects in Mechanistic and Theoretical Studies"
|
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:20 pm | Sander van den Driesche (MRC Centre for Reproductive Health, Edinburgh UK)
"Species Differences in Susceptibility to Testosterone Inhibition"
|
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 7:50 pm | Ravinder Anand-Ivell (University of Nottingham, UK)
"A Large Case Male Reproduction Control Study of Human Pregnancy Links Amniotic Fluid INSL3 to Phthalate load, Smoking, and Cryptorchidism"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Thyroid and Neurodevelopment |
| 9:00 am - 9:05 am | Discussion Leader: Tom Zoeller (U. Mass)
"Introduction" |
| 9:05 am - 9:35 am | Jean-Baptiste Fini (CNRS, France)
"How EDCs Affect Thyroid Signaling at the Whole Organism and Cellular Levels and the Development of Humanized Model Organism Bioassays"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Selected from GRS Posters: Stephanie Degroote (Sherbrooke University)
"Perinatal Exposure to a Mixture of Common Phthalates and Flame Retardants at Low Doses Leads to Autistic Traits in Lewis Rats"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:30 am - 11:00 am | David Sharlin (Minnesota State University)
"EDCs Thyroid Hormone Action and Auditory Development in Animal Models"
|
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Tomas Trnovec (Slovak Medical University, Slovakia)
"PCBs Thyroid Disruption and Hearing in Humans"
|
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Susan Schantz (Unversity of Illinois)
"Developmental PCB Exposure, Thyroid Disruption and Altered Sensitivity to Audiogenic and Kindling-Induced Seizures" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | Thyroid Disruption in Wildlife |
| 6:00 pm - 6:10 pm | Discussion Leader: Barbara Demeneix (Centre National de Recherche, Paris, France)
"Introduction" |
| 6:10 pm - 6:40 pm | Caren Helbing (U. Victoria, Canada)
"Chilling Insights into Thyroid Hormone Disruption in Frogs" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:20 pm | Christy Morrissey (University of Saskatchewan, Canada)
"Impairment of Migration Behaviour and Activity in Birds - Potential Role of EDCs Affecting Global Declines of Migratory Species" |
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 7:50 pm | Selected from GRS Presentations: Ann Petersen (University of Oregon)
"Gonads, Goiters, Genes and Genomes: An Integrative Approach to Understanding the Molecular Basis of Developmental Abnormalities Caused by Environmental Contaminants"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | Endocrine Disruption, Obesity and Metabolism |
| 9:00 am - 9:05 am | Discussion Leader: Jerry Heindel (NIEHS, USA)
"Introduction" |
| 9:05 am - 9:35 am | Juliette Legler (VU University, Amsterdam)
"OBELIX: Developmental Exposure to Obesogens and Their Effects" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:05 am | Heli Routti (Norwegian Polar Institute)
"Does Contaminant Exposure Interfere with Polar Bears' Ability to Sustain Climate Change?"
|
| 10:05 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:30 am - 11:00 am | Richard Phipps (U. Rochester)
"Environmental Obesogens and Skewing of Fibroblasts Towards Fat Cells" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:40 am | Mike Ross (UCLA)
"Developmental Programming of Obesity by Maternal Nutrient and EDC Acting via Effects on Adipogenesis and Control of Appetite and Satiety" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Michele La Merrill (University of California at Davis)
"Perinatal DDT Exposure Impairs Energy Expenditure and Metabolism in Adult Female Mice"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:30 pm | Free Time |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm - 8:00 pm | EDCs and Immunity |
| 6:00 pm - 6:10 pm | Discussion Leader: Brenda Eskenazi (Berkeley, USA)
"Introduction" |
| 6:10 pm - 6:40 pm | Paige Lawrence (U. Rochester)
"Early Life Exposures to EDCs Change the Programming of the Immune System via Epigenetic Mechanisms" |
| 6:40 pm - 6:50 pm | Discussion |
| 6:50 pm - 7:10 pm | Tine Hectors (University of California, Irvine)
"Old Chemicals, New Mechanism: The Steroid and Xenobiotic Receptor (SXR) as a Mechanistic Link Between Polychlorinated Biphenyls and Non-Hodgkin's Lymphoma?"
|
| 7:10 pm - 7:20 pm | Discussion |
| 7:20 pm - 7:50 pm | Philippe Grandjean (U. Southern Denmark)
"Immune System Dysfunction in Children Exposed to Endocrine Disrupting Substances" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |