Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Unusual Natural Product Enzymology |
| Discussion Leader: Squire Booker (Pennsylvania State University, USA) |
7:40 pm - 8:10 pm | Bradley Moore (Scripps Institution of Oceanography, USA) "Marine Natural Products as an Inspiration for New Biosynthetic Enzymology" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Gregory Challis (University of Warwick, United Kingdom) "Elucidating and Exploiting Biosynthetic C-H Functionalization" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Christianson (University of Pennsylvania, USA) "Structural Biology and Chemistry of Histone Deacetylases in Human Disease and Drug Discovery" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Large Complexes |
| Discussion Leader: Martin St. Maurice (Marquette University, USA) |
9:00 am - 9:30 am | Timm Maier (University of Basel, Switzerland) "Structure and Evolution of Fatty Acid and Reducing Polyketide Synthases" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Shelley Minteer (University of Utah, USA) "Substrate Channeling in Natural and Artificial Krebs Cycle Metabolons" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Group Photo / Coffee Break |
10:50 am - 11:05 am | Songon An (University of Maryland, Baltimore County, USA) "A Regulatory Enzyme Complex for Glucose Metabolism in Living Cells: 'The Glucosome'" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Liang Tong (Columbia University, USA) "Structure and Function of Large Metabolic Enzymes" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Lorenzo Finci (Tsinghua University, China) "Structure and Function of the Spliceosome" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Unusual Coenzymes |
| Discussion Leader: Tadhg Begley (Texas A&M University, USA) |
7:30 pm - 8:00 pm | Paul Fitzpatrick (University of Texas Health Science Center, USA) "Regulation of the Pterin-Dependent Aromatic Amino Acid Hydrolases" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Robert White (Virginia Tech, USA) "Digging for Metabolic Fossils in the Methanogenic Archaea" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Hung-Wen Liu (University of Texas at Austin, USA) "Characterization of a Cobalamin-Dependent Radical SAM Enzyme" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Enzyme Inhibition |
| Discussion Leader: Lynn Abell (Bristol-Myers Squibb, USA) |
9:00 am - 9:30 am | Dennis Murphy (Merck Research Laboratories, USA) "Determination of In Vivo Enzyme Occupancy Utilizing Inhibitor Dissociation Kinetics" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Benjamin Cravatt (Scripps Research Institute, USA) "Enzyme and Inhibitor Discovery Using Chemical Proteomics" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Alan Rendina (GlaxoSmithKline, USA) "A Fatty Acid Synthase KRyptonite for Structure, Mechanism and Cancer" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Brian Miller (Florida State University, USA) "Allokairic Regulation of Enzyme Function" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Dali Liu (Loyola University Chicago, USA) "Molecular Recognition of Pyruvate as an Allosteric Activator for ADP-Glucose Pyrophosphorylase from Agrobacterium tumefaciens" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Y. George Zheng (University of Georgia, USA) "Mechanistic Insights of Protein Arginine Methyltransferases" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Metalloenzymes |
| Discussion Leader: Catherine Goodman (Journal of Biological Chemistry, USA) |
7:30 pm - 8:00 pm | Pinghua Liu (Boston University, USA) "Endoperoxide Formation by an a-Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzyme" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Hideaki Ogata (Max Planck Institute for Chemical Energy Conversion, Germany) "Catalytic Reaction Mechanism of [NiFe] Hydrogenase" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Amie Boal (Pennsylvania State University, USA) "Metallocofactor Assembly in a Novel Manganese-Dependent Class I Ribonucleotide Reductase" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Determining Enzyme Function |
| Discussion Leader: Elham Behshad (Incyte Corp., USA) |
9:00 am - 9:30 am | Graham Moran (University of Wisconsin-Milwaukee, USA) "Renalase, a Decade of Phantoms" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Reuben Peters (Iowa State University, USA) "Mechanistic Insights from Systematic Investigation of (Di)Terpenoid Biosynthesis" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Rebecca Butcher (University of Florida, USA) "Discovery and Biosynthesis of Hybrid Polyketide-Nonribosomal Peptides in Nematodes" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Valerie De Crecy-Lagard (University of Florida, USA) "Discovering Novel and Missing Enzymes by Comparative Genomics" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Elizabeth Sattely (Stanford University, USA) "Plant Pathway Discovery for Plant and Human Health" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Biocatalysis |
| Discussion Leader: Thomas Meek (Texas A&M University, USA) |
7:30 pm - 8:00 pm | Jon Stewart (University of Florida, USA) "Understanding Alkene Reductases and Learning How to Make Them Better Biocatalysts" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Robert Dicosimo (DuPont Industrial Biosciences, USA) "Enzymatic Production of Soluble Carbohydrate Fiber for Food Ingredient Applications" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Kevin Walker (Michigan State University, USA) "Biocatalysis and Repurposing of Enzymes on Pathways to Bioactive Natural Products" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Assembly Lines |
| Discussion Leader: Barbara Gerratana (National Institute of General Medical Sciences, NIH, USA) |
9:00 am - 9:30 am | Sheryl Tsai (University of California, Irvine, USA) "Structural Enzymology and Protein Dynamics of Fatty Acid, Polyketide, and Nonribosomal Peptide Megasynthases" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Steven Bruner (University of Florida, USA) "Structure and Mechanism of the Transporter for the E. coli Genotoxin, Colibactin" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Charles Melancon (University of New Mexico, USA) "A Bioinformatic Roadmap for Discovering and Engineering Type II Polyketide Biosynthetic Pathways and Enzymes" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:20 am | Jorn Piel (Institute of Microbiology, ETH Zurich, Switzerland) "Investigating and Utilizing trans-AT Polyketide Synthase Assembly Lines" |
11:20 am - 11:30 am | Discussion |
11:30 am - 12:00 pm | Andrew Gulick (Hauptman-Woodward Medical Research Institute, University at Buffalo, USA) "Conformational Changes that Drive the Dynamic Structural Cycle of the Nonribosomal Peptide Synthetases" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Martin Schmeing (McGill University, Canada) "Visualizing the First Steps of a Megaenzyme Making an Antibiotic" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session |
5:30 pm - 7:30 pm | Keynote Session: Learning from Naturally Gifted Enzymes |
| Discussion Leader: Karen Allen (Boston University, USA) |
5:30 pm - 6:20 pm | Debra Dunaway-Mariano (University of New Mexico, USA) "Catalytic Diversity Among Phosphotransferases: Vignettes of Mechanism and Molecular Evolution" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 7:20 pm | Dale Poulter (University of Utah, USA) "Biosynthesis of Squalene. Five Enzymes, Two Coenzymes, and a Metabolic Pathway" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |