Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Novel Cofactors and Chemistry
7:40 pm - 8:10 pm
"Prenyl-Flavin: A New Cofactor for Aromatic Decarboxylations"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Lactate Racemase and Its Novel Ni-Pincer Cofactor"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Discovery of a PLP-Dependent Oxidase in the Pathway to the Antibiotic Indolmycin"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Advances in Structural Methodology
9:00 am - 9:30 am
"High-Resolution Protein Structures by CryoEM - Is Crystallography Obsolete"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Atomic Resolution Cryo-EM of Metabolic Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
"Structure and Dynamics from Single-Particle Snapshots"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"MauG Catalysis: A Tale of Ferryl Iron, Radicals and Long Distance Hopping"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Metabolite Repair, a Neglected but Essential Aspect of Intermediary Metabolism: The Case for Nit1 in the Recycling of Damaged Glutathione"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"On the Mechanism of Generation, Recognition, and Erasure of DNA Modifications"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"New Metallo-Enzymes Regulating Protein Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Role of Catalysis in Mitotic Checkpoint Control over the Cell Cycle"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enzyme Discovery, Structure and Mechanism
9:00 am - 9:30 am
"Investigations of Regulatory and Functional Diversity in an Enzyme Superfamily"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Regulation of Carrier Domain Movements in Pyruvate Carboxylase"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Noncanonical Reactions Catalyzed by Atypical Flavoenzymes"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A Simplified Approach for the Determination of the Bi-Bi Steady-State Kinetic Mechanism of PA0660"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Old and New Twists on Cytochrome P450: Desaturation, C-C Bond Cleavage, and Reversible Oxidation of the Thiolate Heme Ligand"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Directed Evolution of Abiological Catalysts Based on Heme Proteins"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"H Transfer and Biocatalysis with Natural and Artificial Coenzymes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Using Chemoproteomic Platforms to Map Druggable Hotspots in Human Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Probing the Cofactor Biogenesis in Cysteine Dioxygenase with Unnatural Amino Acid"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Chemical Approaches to Investigate Protein Glutathionylation in Stress"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Alpha-Synuclein Sensitizes Transglutaminase 2 (TG2) to Ca2+ Activation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 8:00 pm
"Regio-Complementary Carboxylation of Aromatics: Diverging Reactivities Through Different Enzyme Mechanisms"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Treatment of Inborn Errors of Metabolism by Small Molecule Allosteric Activators"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Development of New and Improved Enzymes for Industrial Biocatalysis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Protein Dynamics and Catalysis: Evolution and Artificial Design"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mechanisms of Mononuclear Non-Heme Enzymes Studied with Computational Methods"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Recreating the Evolution of Enzyme Catalysis Over 3.5 Billion Years"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Investigating Glycopeptide Antibiotic Biosynthesis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Method to Access Novel Allosteric Regulators and What They Can Teach Us"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Biosynthesis of Non-Proteinogenic Amino Acids"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Evolving State of the Art
5:30 pm - 6:20 pm
"How Can One Enzyme Act on 30 Different Substrates?"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 7:20 pm
"A Century of Enzyme Kinetic Analysis"
7:20 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
