Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Chemical Logic of Life: Visualizing, Sensing, and Predicting Cellular Function
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Illuminating the Biochemical Activity Architecture of the Cell"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"The Many Guises of Reactive Metabolite Signaling"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"AI for Understanding Enzyme Function and for Pedicting the Effects of Missense Mutations on Biochemical Activity"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Unlocking New Potential in Natural Products
9:00 am - 9:30 am
"Exploring Reaction Diversity of Mononuclear Non-Heme Iron Enzymes and Beyond"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Fascinating Enzymes of Riboflavin Biosynthesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Linking Biosynthetic Genes to Metabolites Using Inverse Stable Isotopic Labeling (InverSIL)"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:35 am
"Siderophore Biosynthesis with NRPSs or NIS Synthetases... Why not both?"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Unlocking the Power of Flavin- and Nicotinamide-Dependent Old Yellow Enzymes for Cofactor-Free Catalysis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Functional Characterization of the Cyclopropane Fatty Acid Synthase from Pseudomonas Aeruginosa"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Landscape of 5mYOXs and Associated DNA Modification Machinery From Bacteriophage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Decoding Post-Translational Modifications
7:30 pm - 8:00 pm
"Advancing Drug Discovery by Targeting Protein Tyrosine Dephosphorylation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Enzymatic Swiss Army Knives for Peptide Backbone Modifications"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Paradoxes of Protein SUMOylation: A Role for Biomolecular Condensates?"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamics and Kinetics: Bridging Time, Motion, and Function
9:00 am - 9:30 am
"Kinetics and Mechanism of Retrotransposon Replication of RNA Affording Efficient, Site-Specific Insertion of Large Genes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Using Statistical Structural Biology to Understand Enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"DNA Targeting by Compact Cas9d and Its Resurrected Ancestor"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Nature's Switches: Harnessing Environmental Signals to Control Enzymatic Activity"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Engineering Activation Loop Dynamics to Rewire Kinase Signaling Specificity in c-Src"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Applying Chemical Biology Tools Toward Understanding Histone Monoaminylation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deciphering Tryptophan Oxygenation: Key Modulators of 2-Oxindole Formation in MarE"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative Paths in Enzyme-Driven Catalysis
7:30 pm - 8:00 pm
"Remarkable New Enzymology Involved in the Biosynthesis of the Thiamin Pyrimidine"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Giant Marine Enzymes in Giant Toxin Assembly Line Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Design Principles for Rieske Chemistry"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Unlocking Therapeutic Potential of Enzyme Inhibition in Drug Development
9:00 am - 9:30 am
"Allosteric Activation of Metabolic Pathways as a Novel Antibiotic Strategy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Bullet Time: MAT Isoform Selectivity Through Allosteric Braking"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Impact of Disease-Associated Mutations on DNA Methyltransferase 1"
11:00 am - 11:05 am
Discussion
11:05 am - 11:35 am
"MOPEDâ„¢: A Novel Platform for the Discovery of Molecular Glues"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Unveiling the Control of Mycobacterium Tuberculosis GDH"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Disruption of the CDC37 Co-Chaperone and Client Kinases by an Allosteric RAF Dimer Breaker"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Conserved Glutamate Residue Controls Metal Ion Coordination and Catalytic Dynamics in Protein Kinase A"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Code Meets Catalysis: Exploring Computational Enzymology
7:30 pm - 8:00 pm
"Protein Functional Motion Prediction Led by Long Timescale Molecular Dynamics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Long-Range Radical Transport in Ribonucleotide Reductase"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"AI Protein Profiling (AiPP) for Proteome-Wide Discovery of Druggable Pockets and Ligandable Cysteines"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unlocking Data with Machine Learning and High-Throughput Assays
9:00 am - 9:30 am
"Learning the Protein Structure Distribution with Ambient Diffusion"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Leveraging Evolutionary-Scale Enzymology to Map and Predict Catalytic Landscapes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Advancing Oligonucleotide Manufacturing Using Engineered Biocatalysts"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Programmable Modulators of Conformationally Diverse Target Substrates via Generative Language Models"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Using High-throughput Microfluidic Enzymology for Machine Learning-Informed Functional Prediction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Intramolecular Epistasis Correlates With Divergence of Specificity in Promiscuous and Bifunctional NSAR/OSBS Enzymes"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Computational Insights into Photoenzyme Design: Microenvironment Tuning of Charge Transfer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Unusual Chemistry Carried Out by Enzymes
7:30 pm - 8:15 pm
"Mechanistic Studies of Unusual Biosynthetic Enzymes"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure