Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Understanding and Designing Enzyme Function
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
"Learning to Design Enzymes From Scratch"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Do We Actually Need Cells? The Promise of Cell-Free Enzymatic Pathways: From Generative AI Enzyme Design to Manufacturing at Commercial Scale"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Emergent Mechanisms in Photoenzymatic Catalysis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Designing Metalloenzymes with Native or Non‑Native Cofactors: Gaining Biological Insight and New Functions"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Expanding the Genetic Code for Next-Generation Enzyme Engineering"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Crosslinks and Catalysis: How Enzymes Build Chemistry Into Proteins
7:30 pm - 8:00 pm
"Biosynthesis and Utilization of Nickel-Pincer Nucleotide (NPN) Cofactors"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Emerging Radical Strategies in Peptide Antibiotic Biosynthesis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Protein-Derived Met–Tyr–Trp Cofactor in KatG: A Fresh Look"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:30 am
"Molecular Determinants of Selective Inhibition of Human IDO1 and TDO"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Excited States of Ferryl Heme in Dye-Decolorizing Peroxidases"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Unmaking Heme Without O2, From Guts to Mire"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enzymology in Application and Translation
7:30 pm - 8:00 pm
"Understanding and Manipulating Ubiquitin Ligase Specificity"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Structural Basis for RNA Editing by ADARs: Advancing Tools to Treat Genetic Disorders"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"An Unlikely Alliance: Cooperative Kinase-Phosphatase Signaling in Acute Myeloid Leukemia"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nucleic Acid Modification and Regulation
9:00 am - 9:30 am
"The Roles of TRMT61A and ALKBH3 in Modulating CAG Repeat Expansion Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Engineering CRISPR Systems for Precision Therapeutics and Molecular Innovation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Targeting Epigenetic Proteins by Phage-Encoded Posttranslational Modifications for Drug Development"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Natural Pathways and Synthetic Networks
7:30 pm - 8:00 pm
"Coordinating Metabolic Fluxes Through Metabolite-Protein Interactions"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Engineering of Highly Selective Biocatalysts for the Chemoenzymatic Synthesis of Enlicitide"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Structural Phylogenetics Illuminates the Diversification of Early Metabolism"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanistic Insight from Enzyme Kinetics and Dynamics
9:00 am - 9:30 am
"Discovery of More Twists and Turns in the Tautomerase Superfamily"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Tuning Chalcone Synthase: Mechanistic Roles of CHIL"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"An Activity-Resistance Tradeoff Constrains IMPDH Evolution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: De Novo Enzyme Design
7:30 pm - 8:15 pm
"De Novo Design of Functional Proteins Including Enzymes"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"Complete Computational Design of Efficient Enzymes"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure