| Saturday |
| 2:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Keynote Session: Enzymes: Structure and Function |
| Discussion Leader: Randy Kipp (Novartis Institutes for Biomedical Research, USA) |
| 3:45 pm - 4:15 pm | Dan Herschlag (Stanford University, USA)
"How Enzymes Work" |
| 4:15 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Fundamentals of Enzymatic Catalysis |
| Discussion Leader: Sourav Roy (Jawaharlal Nehru Centre for Advanced Scientific Research, India) |
| 7:30 pm - 7:50 pm | Zahidul Islam (University of Iowa, USA)
"Mechanistic Investigation of the Proton Abstraction in the Thymidylate Synthase-Catalyzed Reaction" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Crystal Smitherman (Georgia State University, USA)
"Excited State Proton Transfers in Flavoprotein Oxidases" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Michael Funk (Massachusetts Institute of Technology, USA)
"Substrate Recognition by the Radical Enzyme Benzylsuccinate Synthase" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Daniel Roston (University of Wisconsin, USA)
"Enzymatic Phosphoryl Transfer: Reaction Pathways, Transition State Structures, and the Catalytic Roles of Arginine" |
| 9:20 pm - 9:30 pm | Discussion |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Applications of Enzymology |
| Discussion Leader: Shalinee Jha (Graz University of Technology, Austria) |
| 9:00 am - 9:20 am | Emilia Arturo (Fox Chase Cancer Center / Drexel University College of Medicine, USA)
"The First X-Ray Crystal Structure of Full-Length Mammalian Phenylalanine Hydroxylase" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Hitomi Nakamura (Harvard University, USA)
"Discovery and Characterization of the Cylindrocyclophane Biosynthetic Gene Cluster" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Joao Pisco (Francis Crick Institute, United Kingdom)
"Allosteric Control of M. tuberculosis ATP-Phosphoribosyltransferase" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Bharath Srinivasan (Georgia Institute of Technology, USA)
"Prediction of Binding and Detailed Mechanistic Characterization of Novel Pyrroloquinazolinediamine Derivatives as Inhibitors of Escherichia coli Dihydrofolate Reductase" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Mentorship Component: Shaping Your Career in Academia or Industry |
| Discussion Leader: Zhen Wang (Albert Einstein College of Medicine, USA) |
| 1:30 pm - 2:30 pm | Panel Discussion |
| "Perspectives from Junior and Veteran Investigators on Academic and Industrial Careers" |
|
- Nozomi Ando (Princeton University, USA)
- Giovanni Gadda (Georgia State University, USA)
- Mark Hixon (Takeda California Inc., USA)
- Shuo Wang (Takeda California Inc., USA)
- Dan Herschlag (Stanford University, USA)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
