1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Enzyme Mechanism and Mentoring
Eric Greene (University of California San Francisco, United States)
3:45 pm - 4:15 pm
Kayunta Johnson-Winters (University of Texas at Arlington, United States) "Mentoring Students from Diverse Backgrounds using Rigorous Enzymological Methods to Study F
4:15 pm - 4:30 pm
4:30 pm - 6:00 pm
6:00 pm - 7:00 pm
7:30 pm - 9:30 pm
Principles of Enzyme Function, Regulation and Design
Marta Massari (University of Pavia, Italy)
7:30 pm - 7:45 pm
Linna An (University of Washington, United States) "De Novo Small Molecule Binder Design with Shape Complimentary Sampling"
7:45 pm - 7:50 pm
7:50 pm - 8:05 pm
Chang Cui (Harvard University, United States) "Probe Two Stages of Conformational Gating in Ribonucleotide Reductase Using 3,4-Dihydroxyphenylalanine"
8:05 pm - 8:10 pm
8:10 pm - 8:25 pm
Christoph Meier (ETH Zurich, Switzerland) "Origamins: A Widespread Family of Hypermodified Beta-Helical Peptides"
8:25 pm - 8:30 pm
8:30 pm - 8:45 pm
Rajleen Gogar (The University of Alabama, United States) "The ß-latch Structural Element of the SufS Cysteine Desulfurase Mediates Active Site Accessibility and SufE Transpersulfurase Positioning"
8:45 pm - 8:50 pm
8:50 pm - 9:05 pm
Amanda Laseke (Marquette University, United States) "An Allosteric Site at the Biotin Carboxylase Dimer Interface Mediates Activation and Inhibition in Staphylococcus Aureus Pyruvate Carboxylase"
9:05 pm - 9:10 pm
9:10 pm - 9:25 pm
Vishav Sharma (Texas A&M University, United States) "Phosphomethylpyrimidine Synthase (ThiC): A “Radical Dance’’ in Bacterial Thiamin Biosynthesis"
9:25 pm - 9:30 pm
7:30 am - 8:30 am
9:00 am - 11:00 am
Structure, Function and Evolution of Enzymes and Metabolic Pathways
Max Sosa (UC Berkeley, United States)
9:00 am - 9:15 am
Callum Nicoll (University of Pavia, Italy) "Harnessing Ancestral Sequence Reconstruction as a Multifaceted Tool to Probe Enzyme Function, Structure and Evolution"
9:15 am - 9:20 am
9:20 am - 9:35 am
Finn Gude (Leibniz Institute for Natural Product Research and Infection Biology (Hans Knöll Institute) Jena, Germany) "Antibiotic Self-Resistance in Anaerobic Bacteria Conferred by a Polythioamide-Binding Protein"
9:35 am - 9:40 am
9:40 am - 9:55 am
Sreyashi Sinha (Texas A&M University, United States) "Characterization of Bacterial Vitamin B
2 Catabolic Pathway"
9:55 am - 10:00 am
10:00 am - 10:15 am
Zhipeng Wang (Brigham and Women’s Hospital & Harvard Medical School, United States) "Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation and Deacylation"
10:15 am - 10:20 am
10:20 am - 10:35 am
Wojciech Witek (Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poland) "Structural and Functional Characterization of the Histidine Biosynthetic Pathway in Plants"
10:35 am - 10:40 am
10:40 am - 10:55 am
Di Yang (University of Michigan, United States) "Ancestral Sequence Reconstruction Guided Function Switch of Non-heme Iron Oxygenases"
10:55 am - 11:00 am
11:00 am - 12:30 pm
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
1:30 pm - 2:30 pm
Mentorship Component: Navigating Your Early Career
Joanna Afokai Quaye (Georgia State University, United States)
1:30 pm - 2:30 pm
Navigating your Early Career
Anke Krebber (TBD, Former Codexis, United States)
Catherine Drennan (Massachusetts Institute of Technology, United States)
Kayunta Johnson-Winters (University of Texas at Arlington, United States)
2:30 pm - 3:00 pm
Complete the GRS Evaluation Forms; Election of Future Chair(s)