| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 4:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Inheritance: Remembrance of things past |
| 7:30 pm | Welcoming Remarks |
| Discussion Leader: Marisa Bartolomei (University of Pennsylvania School of Medicine) |
| 7:35 pm | Special Lecture (The Cruickshank Award Presentation):
Vicki Chandler (University of Arizona)
No rules, no bars, no guidelines: Looking beyond |
| 8:10 pm | James Sherley (Massachusetts Institute of Technology)
Immortal DNA strands and adult stem cell asymmetric-self renewal |
| 8:35 pm | Stretch |
| 8:40 pm | Marisa Bartolomei (University of Pennsylvania School of Medicine)
Regulation of H19 imprinting in the germline and early embryo |
| 9:05 pm | Robert Pruitt (Purdue University)
Non-mendelian inheritance of DNA sequence information in Arabidopsis |
| 9:30 pm | End of Session |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | Homology in development and defense |
| Discussion Leader: Marjori Matzke (Gregor Mendel Institute of Molecular Plant Biology) |
| 9:00 am | Marjori Matzke (Gregor Mendel Institute of Molecular Plant Biology)
RNA-directed DNA methylation |
| 9:25 am | Benjamin Normark (University of Massachusetts)
The evolution of paternal genome elimination in insects |
| 9:50 am | Vett Lloyd (Mt. Allison Univeristy)
Genomic imprinting in sexually produced and cloned Drosophila |
| 10:10 am | Carmen Sapienza (Temple University)
Epigenetic marks: not just for transcription anymore |
| 10:35 am | Coffee Break |
| 11:00 am | Jennifer Graves (Australian National University)
The evolution of genomic imprinting in mammals |
| 11:25 am | Edith Heard (Curie Institute)
The nuclear and epigenetic dynamics of X-chromosome inactivation |
| 11:50 am | Jeffrey Chen (Texas A&M University)
Epigenetic regulation and evolutionary impact in plant polyploids |
| 12:10 pm | Oliver Muhlemann (University of Bern)
Transcriptional silencing of immunoglobulin minigenes with premature translation-termination codons |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Change and the environment |
| Discussion Leader: Jean Finnegan (CSIRO Plant Industry) |
| 7:30 pm | Jean Finnegan (CSIRO Plant Industry)
FLC, the epicentre of a gene expression domain |
| 7:55 pm | Suzanne Rutherford (Fred Hutchinson Cancer Research Center)
Regulation of canalization and evolvability by Hsp90 |
| 8:20 pm | Robert Waterland (Baylor University School of Medicine)
Nutritional epigenetics in axin-fused mice: Kinky "tales" about mom's diet |
| 8:40 pm | Stretch |
| 8:45 pm | Eric Richards (Washington University)
Natural variation of cytosine methylation |
| 9:10 pm | Marcello Nobrega (University of Chicago)
Mapping and function of ultra-conserved sequences in vertebrate genomes |
| 9:30 pm | End of Session |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Crosstalk: Getting the message across |
| Discussion Leader: William Kelly (Emory University) |
| 9:00 am | William Kelly (Emory University)
Meiotic silencing, chromosome evolution, and X chromatin imprinting in C. elegans |
| 9:25 am | Jeannie Lee (Massachusetts General Hospital)
Weaving a cohesive tale of X-inactivation, imprinting, and non-coding RNAs |
| 9:50 am | Carole Charlier (University of Liege)
Progress in the understanding of polar overdominance at the calliphyge locus |
| 10:10 am | Craig Pikaard (Washington University)
Nucleolar dominance and RNA polymerase IV |
| 10:35 am | Coffee Break |
| 10:55 am | James Birchler (University of Missouri)
RNA silencing machinery: pairing sensitive silencing, Lighten-up and cell death |
| 11:20 am | Anne Ferguson-Smith (University of Cambridge)
Cis and trans regulation at the Dlk1-Dio3 imprinted domain on distal chromosome 12 |
| 11:45 am | Tetsuji Kakutani (National Institute of Genetics)
Epigenetic mutations and transposons in Arabidopsis |
| 12:05 pm | Floyd Romesberg (Scripps Research Institute)
Efforts toward the expansion of the genetic alphabet |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | One scoop or two: Dosage and gene regulation |
| Discussion Leader: Wolf Reik (Babraham Institute) |
| 7:30 pm | Wolf Reik (Babraham Institute)
How imprinting centres work |
| 7:55 pm | Victoria Meller (Wayne State University)
Global chromosome regulation in Drosophila: dosage compensation and germ line imprinting |
| 8:15 pm | Patrick McDonel (University of California, Berkeley)
Sex and rex: establishing a chromosome-wide repressive state on X |
| 8:35 pm | Stretch |
| 8:40 pm | Ortrun Mittelsten Scheid (Gregor Mendel Institute of Molecular Plant Biology)
Epialleles in polyploid Arabidopsis: going back and forth |
| 9:05 pm | Ueli Grossniklaus (University of Zürich)
Evolutionary implications of epigenetic phenomena in plants |
| 9:30 pm | End of Session |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Switching: Decisions, decisions, decisions |
| Discussion Leader: Timothy Bestor (Columbia University) |
| 9:00 am | Timothy Bestor (Columbia University)
Biological functions of Dnmt2 in Diptera and mammals |
| 9:25 am | Benjamin Kaufmann (Harvard/MIT)
Switching of telomere expression state in single cells |
| 9:45 am | Erika Matunis (Johns Hopkins School of Medicine)
Mechanisms of stem cell renewal in the Drosophila testis |
| 10:10 am | Elena Gostjeva (Massachusetts Institute of Technology)
Hollow bell-shaped nuclei: symmetrical-asymmetrical nuclear fissions in cells with stem-like qualities in human embryos and tumors |
| 10:35 am | Coffee Break |
| 11:00 am | Barbara Panning (University of California, San Francisco)
Randomness and sex (chromosomes) |
| 11:25 am | Benjamin Shykind (Columbia University)
Generation of neuronal diversity in the nose |
| 11:45 am | Marc Meneghini (University of California, San Francisco)
Cell cycle-dependent reversal of euchromatic epigenetic modifications is required for establishment of silent heterochromatin |
| 12:05 pm | Amar Klar (National Cancer Institute)
Epigenetic mechanism for human brain laterality development and implications for psychoses development |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keeping the peace |
| Discussion Leader: Sarah Elgin (Washington University) |
| 7:30 pm | Sarah Elgin (Washington University)
Targeting heterochromatin formation in Drosophila: What are the critical inputs? |
| 7:55 pm | Steve Jacobsen (University of California, Los Angeles)
Genetics of DNA methylation in Arabidopsis |
| 8:20 pm | Diane Genereux (University of Washington)
Double-stranded methylation patterns: insights into maintenance and de novo methylation |
| 8:40 pm | Amy Pasquinelli (University of California, San Diego)
Post-transcriptional control of gene expression by miRNAs in C. elegans |
| 9:05 pm | Jasper Rine (University of California, Berkeley)
Plentiful paralogs: Batman, look at all those SIR1s |
| 9:30 pm | End of Session |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Everything in its place: Genome organization |
| Discussion Leader: Robert Martienssen (Cold Spring Harbor Laboratories) |
| 9:00 am | Robert Martienssen (Cold Spring Harbor Laboratories)
RNAi, heterochromatin and the epigenome of Arabidopsis and fission yeast |
| 9:25 am | Rudolf Jaenisch (Massachusetts Institute of Technology)
Nuclear cloning, stem cells and reprogramming of the genome |
| 9:50 am | Marta Svartman (National Institutes of Health/NCI)
Dissecting the polyploid mammal genome |
| 10:10 am | Steven Fiering (Dartmouth Medical School)
Transcriptional interference: an epigenetic variable |
| 10:30 am | Coffee Break |
| 10:55 am | Emma Whitelaw (University of Sydney)
An ENU screen for genes involved in variegation in the mouse |
| 11:20 am | Alexander Gimelbrant (MIT)
Epigenetic status associated with areas of tandem gene duplication |
| 11:40 am | Sabine Schmitt (University of Heidelberg)
Intergenic transcription through a Polycomb group response element counteracts silencing |
| 12:00 pm | Jeffrey Jeddeloh (Orion Genomics)
Toward a comprehensive cytosine-methylation profile of the human genome |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | Looking forward |
| Discussion Leader: Eric Selker (University of Oregon) |
| 7:30 pm | Steve Henikoff (Fred Hutchinson Cancer Research Center)
Epigenetic patterns generated by assembly of histone variants into nucleosomes |
| 8:00 pm | Denise Barlow (Ce-M-M- Research Center for Molecular Medicine of the Austrian Academy of Science)
Air your views - is genomic imprinting a model for epigenetic gene regulation in mammals? |
| 8:30 pm | Janet Seiffert (Rice University)
An astrobiological look at evolving information systems: Horizontal gene transfer in the prokaryotic world |
| 9:00 pm | End of Session |
| Weather permitting, we will adjourn the session and reassemble on the Holderness Quadrangle to view the Perseid Showers together. |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
