| SUNDAY | 
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) | 
| 6:00 pm | Dinner | 
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff | 
| 7:35 pm - 7:40 pm | Welcome Note by the Organizers | 
| 7:40 pm - 9:30 pm | CLASSIC EPIGENETIC PHENOMENA | 
 | Discussion Leader: Eric Richards (Cornell University) | 
| 7:40 pm - 7:55 pm	 | Vicky Chandler (University of Arizona)  
"Epigenetic Silencing across Generations" | 
| 7:55 pm - 8:00 pm	 | Discussion | 
| 8:00 pm - 8:15 pm	 | Paul Soloway (Cornell University)  
"Successful Computational Prediction of Novel Imprinted Genes from Epigenomic Features" | 
| 8:15 pm - 8:20 pm	 | Discussion | 
| 8:20 pm - 8:35 pm	 | Ting Wu (Harvard Medical School)  
"Implications of homology" | 
| 8:35 pm - 8:40 pm	 | Discussion | 
| 8:40 pm - 8:55 pm	 | Steve Henikoff (Fred Hutchinson Cancer Research Center)  
"Epigenetic Inheritance of Centromeric Chromatin" | 
| 8:55 pm - 9:00 pm	 | Discussion | 
| 9:00 pm - 9:10 pm	 | Short Talk: Doug Chalker (Washington University, St. Louis)  
"Dynamic nuclear reorganization and extensive genome rearrangements remodel the differentiating somatic nucleus of Tetrahymena"			 | 
| 9:10 pm - 9:15 pm	 | Discussion | 
| 9:15 pm - 9:30 pm	 | Eric Richards: Synthesis & Discussion - What is epigenetics? | 
| MONDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 8:45 am | Group Photo | 
| 9:00 am - 12:30 pm | GERMLINE & TRANSGENERATIONAL INHERITANCE | 
 | Discussion Leader: William Kelley (Emory University, GA) | 
| 9:00 am - 9:15 am	 | Brad Cairns (University of Utah)  
"Chromatin Packaging in Mature Germ Cells" | 
| 9:15 am - 9:20 am	 | Discussion | 
| 9:20 am - 9:35 am	 | Marcus Pembrey (University of Bristol, UK)  
"Male-line Transgenerational Responses in Humans" | 
| 9:35 am - 9:40 am	 | Discussion | 
| 9:40 am - 9:55 am	 | Hiroyuki Sasaki (National Institute of Genetics, Shizuoka, Japan)  
"Genomic Imprinting, DNA Methylation and Small RNAs in Mammalian Germ Cells" | 
| 9:55 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:10 am	 | Short Talk: Yoav Soen (Weizmann Institute, Israel)  
"Trans-generational Inheritance of Plastic Responses to a Novel Challenge Presented to Developing Flies" | 
| 10:10 am - 10:15 am	 | Discussion | 
| 10:15 am - 10:45 am	 | Coffee Break | 
| 10:45 am - 11:00 am	 | Pat Shiu (University of Missouri)  
"Meiotic Silencing by Unpaired DNA" | 
| 11:00 am - 11:05 am	 | Discussion | 
| 11:05 am - 11:20 am	 | James Turner (National Institute for Medical Research, UK)  
"Meiotic Silencing in Mammals" | 
| 11:20 am - 11:25 am	 | Discussion | 
| 11:25 am - 11:35 am	 | Short Talk: Frederic Chedin (UC-Davis)  
"Formation of long, stable R-loops is a novel characteristic of the human SNRPN and mouse Air imprinting centers" | 
| 11:35 am - 11:40 am	 | Discussion | 
| 11:40 am - 11:50 am	 | Short Talk: Jonathan Schneiderman (Harvard Medical School)  
"Transcriptional and germline functions for the H3.3 histone variant" | 
| 11:50 am - 11:55 am	 | Discussion | 
| 11:55 am - 12:05 pm	 | Short Talk: Felipe Texeira (CNRS, France)  
			"Widespread gene misregulation due to loss of DNA methylation over repeat elements in Arabidopsis" | 
| 12:05 pm - 12:10 pm	 | Discussion | 
| 12:10 pm - 12:20 pm	 | William Kelley: Synthesis & Discussion - How much and how far can the germline transmit? | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | EPIGENETIC REPROGRAMMING DURING DEVELOPMENT | 
 | Discussion Leader: Robert Feil (CNRS, France) | 
| 7:30 pm - 7:45 pm	 | Rudolf Jaenisch (Whitehead Institute for Biomedical Research)  
"The Epigenetic (In)stability of the Pluripotent and Differentiated Cell State" | 
| 7:45 pm - 7:50 pm	 | Discussion | 
| 7:50 pm - 8:05 pm	 | Wolf Reik (The Babraham Institute, UK)  
"Regulation of Epigenetic Reprogramming in Mammalian Development" | 
| 8:05 pm - 8:10 pm	 | Discussion | 
| 8:10 pm - 8:25 pm	 | Daniel Grimanelli (Institut de Recherche et Dévelopment, France)  
"Chromatin-Level Control of Reproductive Strategies in Plants" | 
| 8:25 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:45 pm	 | Anne Ferguson-Smith (University of Cambridge, UK)  
"Imprinted Genes and Mammalian Development" | 
| 8:45 pm - 8:50 pm	 | Discussion | 
| 8:50 pm - 9:00 am	 | Short Talk: Frederic Berger (National University of Singapore)  
"Epigenetic Reprogramming of Histone Marks during Sexual Reproduction in Arabidopsis" | 
| 9:00 pm - 9:05 pm	 | Discussion | 
| 9:05 pm - 9:25 pm	 | Robert Feil: Synthesis & Discussion - Challenges during reprogramming | 
| TUESDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | BALANCING THE EPIGENOME | 
 | Discussion Leader: Marisa Bartolomei (University of Pennsylvania) | 
| 9:00 am - 9:15 am	 | Jenny Graves (Australian National University, Australia)  
"The Chromosomal Balancing Act in Marsupials and Monotremes" | 
| 9:15 am - 9:20 am	 | Discussion | 
| 9:20 am - 9:35 am	 | Peter Becker (Munich University, Germany)   
			"Regulation of the Male X in Drosophila by the MSL complex" | 
| 9:35 am - 9:40 am	 | Discussion | 
| 9:40 am - 9:55 am	 | Jim Birchler (University of Missouri)  
Genomic Balance and the Male Specific Lethal (MSL) Complex in Drosophila" | 
 
| 9:55 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:10 am	 | Short Talk: Christine Disteche (University of Washington, Seattle)  
			"Complex Genome-Wide Balancing Acts in Eutherian Mammals" | 
| 10:10 am - 10:15 am	 | Discussion | 
| 10:15 am - 10:45 am	 | Coffee Break | 
| 10:45 am - 11:00 am	 | Barbara Meyer (University of California-Berkeley)  
"Dosage Compensation in Round Worms and its Connection to Meiosis" | 
| 11:00 am - 11:05 am	 | Discussion | 
| 11:05 am - 11:20 am	 | Jeffrey Chen (University of Texas)  
"An Epigenetic Balance around the Clock: a Molecular Basis for Growth Vigor in Hybrids and Allopolyploids" | 
| 11:20 am - 11:25 am	 | Discussion | 
| 11:25 am - 11:40 am	 | Peter Fraser (The Babraham Institute, UK)  
"The transcriptional interactome; overlapping networks of gene co-associations at transcription factories" | 
| 11:40 am - 11:45 am	 | Discussion | 
| 11:45 am - 11:55 am	 | Short Talk: Laura Carrel (Penn State University)  
			"A conserved hypomethylated multi-gene domain on the inactive X chromosome" | 
| 11:55 am - 12:00 pm	 | Discussion | 
| 12:00 pm - 12:20 pm	 | Marisa Bartolomei: Synthesis & Discussion - Are there multiple methods of balancing the genome? Inverse effect versus dosage compensation | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | EPIGENETICS IN HEALTH & DISEASE | 
 | Discussion Leader: Howard Cedar (Hebrew University, Israel) | 
| 7:30 pm - 7:45 pm	 | Amar Klar (National Cancer Institute at Frederick)  
"Cellular Differentiation through Epigenetics and Selective Chromatid Segregation" | 
| 7:45 pm - 7:50 pm	 | Discussion | 
| 7:50 pm - 8:05 pm	 | Steve Baylin (Johns Hopkins University School of Medicine)  
"Epigenetic Misregulation in Cancer" | 
| 8:05 pm - 8:10 pm	 | Discussion | 
| 8:10 pm - 8:25 pm	 | Renato Paro (ETH Zürich, Switzerland)  
"Epigenetic Control of Regeneration" | 
| 8:25 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:45 pm	 | Rosanna Weksberg (SickKids, Canada)  
"Epigenetics and Human Disease" | 
| 8:45 pm - 8:50 pm	 | Discussion | 
| 8:50 pm - 9:05 pm	 | Jasper Rine (University of California-Berkeley)  
			"Effect of folate on gene activity in humans and yeast" | 
| 9:05 pm - 9:10 pm	 | Discussion | 
| 9:10 pm - 9:30 pm	 | Howard Cedar: Synthesis & Discussion - How much of disease is epigenetic versus genetic? | 
| WEDNESDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | ENVIRONMENTAL EPIGENETICS AND BEHAVIOR | 
 | Discussion Leader: Doug Ruden (Wayne State University) | 
| 9:00 am - 9:15 am	 | Patricia Hunt (Washington State University)  
"Epigenetic change effected by environmental toxins" | 
| 9:15 am - 9:20 am 	 | Discussion | 
| 9:20 am - 9:35 am	 | Emma Whitelaw (Queensland Institute of Medical Research, Australia)  
"The Molecular basis of Intangible Variation" | 
| 9:35 am - 9:40 am	 | Discussion | 
| 9:40 am - 9:55 am	 | Ortrun Mittelsten Scheid (Gregor Mendel Institute, Austria)  
"Heat stress causes transient suppression of transcriptional gene silencing" | 
| 9:55 am - 10:00 am	 | Discussion | 
| 10:00 am - 10:10 am	 | Short Talk: Bas Rutjens (John Innes Centre, UK)  
			"Cold-induced epigenetic silencing mediated by long non-coding FLC transcripts" | 
| 10:10 am - 10:15 am	 | Discussion | 
| 10:15 am - 10:45 am	 | Coffee Break | 
| 10:45 am - 11:00 am	 | Moshe Szyf (McGill University, Canada)  
"The impact of the early social environment on the adult epigenome" | 
| 11:00 am - 11:05 am	 | Discussion | 
| 11:05 am - 11:20 am	 | Catherine Dulac (Harvard University)   
"Spatial, Temporal, Sex- and Species-Specific Genomic Imprinting in the Mouse Brain" | 
| 11:20 am - 11:25 am	 | Discussion | 
| 11:25 am - 11:40 am	 | Susan Lindquist (Whitehead Institute for Biomedical Research, MIT)  
"Prion proteins provide a survival strategy for generating heritable phenotypic diversity" | 
| 11:40 am - 11:45 am	 | Discussion | 
| 11:45 am - 12:00 pm	 | Reed Wickner (National Institutes of Health)  
"The structural basis of protein-based inheritance" | 
| 12:00 pm - 12:05 pm	 | Discussion | 
| 12:05 pm - 12:25 pm	 | Doug Ruden: Synthesis & Discussion - Lamarckian genetics via environmental influences and prions? | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:00 pm - 7:30 pm | Business Meeting | 
 | (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) | 
| 7:30 pm - 9:30 pm | CHROMATIN MODIFIERS & DNA METHYLATION | 
 | Discussion Leader: Jean Finnegan (CSIRO, Australia) | 
| 7:30 pm - 7:45 pm	 | Judith Bender (Brown University)  
"The role of small RNAs in maintaining DNA methylation on duplicated sequences" | 
| 7:45 pm - 7:50 pm	 | Discussion | 
| 7:50 pm - 8:05 pm	 | Eric Selker (University of Oregon)  
"Control of DNA Methylation in Neurospora" | 
| 8:05 pm - 8:10 pm	 | Discussion | 
| 8:10 pm - 8:25 pm	 | Steve Jacobsen (University of California-Los Angeles)  
"Regulation of DNA Methylation and Histone Modifications in Arabidposis" | 
| 8:25 pm - 8:30 pm	 | Discussion | 
| 8:30 pm - 8:45 pm	 | Marjori Matzke (Gregor Mendel Institute, Austria)  
"RNA-directed DNA Methylation in Arabidopsis" | 
| 8:45 pm - 8:55 pm	 | Discussion | 
| 8:55 pm - 9:10 pm	 | Andreas Houben (Leibniz Institute of Plant Genetics and Crop Research, Germany)  
"Phosphorylation of Histone H3 in Plants - a Dynamic Affair" | 
| 9:10 pm - 9:15 pm	 | Discussion | 
| 9:15 pm - 9:30 pm	 | Jean Finnegan: Synthesis & Discussion - The connection between DNA & histone methylation in affecting genome behavior | 
| THURSDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am - 12:30 pm | CONTROL BY TRANSPOSONS & ncRNA | 
 | Discussion Leader: Sarah Elgin (Washington University)  | 
| 9:00 am - 9:15 am	 | Tetsuji Kakutani (National Institute of Genetics, Shizuoka, Japan)  
"Genetics of DNA Methylation in Genes and Transposons in Arabidopsis" | 
| 9:15 am - 9:20 am	 | Discussion | 
| 9:20 am - 9:35 am	 | Jim Goodrich (University of Colorado)  
"Regulation of Mammalian mRNA transcription by SINE RNAs" | 
| 9:35 am - 9:40 am	 | Discussion | 
| 9:40 am - 9:50 am	 | Short Talk: Alysson Muotri (University of California-San Diego)  
			"L1 retrotransposition in the Nervous System" | 
| 9:50 am - 9:55 am	 | Discussion | 
| 9:55 am - 10:10 am	 | Denise Barlow (University of Vienna, Austria)  
"Long ncRNA and Imprinting in Mammals" | 
| 10:10 am - 10:15 am	 | Discussion | 
| 10:15 am - 10:45 am	 | Coffee Break | 
| 10:45 am - 11:00 am	 | Shiv Grewal (National Institutes of Health)  
"RNAi-mediated Epigenetic Control of the Genome" | 
| 11:00 am - 11:05 am	 | Discussion | 
| 11:05 am - 11:20 am	 | Danesh Moazed (Harvard Medical School)  
"Noncoding RNAs and Inheritance of Heterochromatin" | 
| 11:20 am - 11:25 am	 | Discussion | 
| 11:25 am - 11:40 am	 | Rob Martienssen (Cold Spring Harbor Laboratories)  
"Copying and Reprogramming Heterochromatin with RNA interference" | 
| 11:40 am - 11:45 am	 | Discussion | 
| 11:45 am - 12:00 pm	 | Tim Bestor (Columbia University)  
"Regulation and Mechanism of de novo DNA methylation" | 
| 12:00 pm - 12:05 pm	 | Discussion | 
| 12:05 pm - 12:25 pm	 | Sally Elgin: Synthesis & Discussion - Is junk DNA no longer junk? | 
| 12:30 pm | Lunch | 
| 1:30 pm - 4:00 pm | Free Time | 
| 4:00 pm - 6:00 pm | Poster Session | 
| 6:00 pm | Dinner | 
| 7:30 pm - 9:30 pm | NUCLEAR ORGANIZATION | 
 | Discussion Leader: Thomas Cremer (Munich University, Germany) | 
| 7:30 pm - 7:45 pm	 | Vince Pirrotta (Rutgers University, NJ)  
			"The role of Polycomb proteins in genome organization" | 
| 7:45 pm - 7:50 pm	 | Discussion | 
| 7:50 pm - 8:00 pm	 | Short Talk: Pam Geyer (University of Iowa)  
			"Stem cell homeostasis in the Drosophila female gonad requires integrity of the nuclear lamina" | 
| 8:00 pm - 8:05 pm	 | Discussion | 
| 8:05 pm - 8:20 pm	 | Alexandre Reymond (University of Lausanne, Switzerland)  
"Genome structure and gene expression" | 
| 8:20 pm - 8:25 pm	 | Discussion | 
| 8:25 pm - 8:40 pm	 | Wendy Bickmore (The Babraham Institute, UK)  
"The repression of gene expression in the nuclear space" | 
| 8:40 pm - 8:45 pm	 | Discussion | 
| 8:45 pm - 9:00 pm	 | Craig Pikaard (Washington University)  
"Functions of nuclear RNA Polymerases IV and V in plant siRNA-directed gene silencing" | 
| 9:00 pm - 9:05 pm	 | Discussion | 
| 9:05 pm - 9:25 pm	 | Thomas Cremer: Synthesis & Discussion - Nuclear organization as an epigenetic mechanism | 
| 9:30 pm | Party | 
| FRIDAY | 
| 7:30 am - 8:30 am | Breakfast | 
| 9:00 am | Depart |