Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:10 pm
"3D Folding and Enhancer Function"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Two Mechanisms of Nuclear Organization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"A Condensate Model for Gene Activity and Genome Organization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Single-Molecule Nanoscopy Elucidates RNA Polymerase II Transcription, Epigenetic Regulation and Genome Organization at Single Genes in Live Cells"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transposable Elements and Epigenome Evolution
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Avoiding Replication and Transcriptional Collisions by Repressing Repeats and Forming Nuclear Foci"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"How TEs and Their Krab-ZFP Controllers Shape Human-Specific Transcription Networks"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"pUG-Tailed RNAs Drive Gene Silencing and Transgenerational Epigenetic Inheritance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Functional Evaluation of Transposable Elements as Enhancers in Mouse and Human Trophoblast"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Control of Non-Coding RNA Production and Histone Levels by a 5'tRNA Fragment"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Using Metatherians to Elucidate the Evolution of Mammalian Epigenetic Pathways"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
RNA-Mediated Epi-Regulation
7:30 pm - 7:50 pm
"Small RNAs and Dosage Interactions in Plants"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Gene Regulation in Arabidopsis "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sexually Dimorphic Expression of piRNAs in C. elegans "
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Paternal Contributions to Offspring Health: Intergenerational Epigenetic Inheritance via Sperm Small RNAs"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Programming Future Generations
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Remembering the Past: A New Form of Protein-Based Epigenetics"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Molecular Principles of Developmental Reprogramming and Gametogenesis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Heterochromatin Establishment by the Chromatin Remodeling Factor DDM1 in Arabidopsis "
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Principles of Nucleosome Phasing Revealed by Genome-Wide Mapping and In Vitro Reconstitution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"The C. elegans MES Chromatin Regulators Ensure Germline Survival by Repressing the X Chromosomes"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"SPR-5; MET-2 Maternal Reprogramming Antagonizes H3K36me3 in the Control of Germline Versus Soma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Reprogramming During Development
7:30 pm - 7:50 pm
"Programmed DNA Elimination: Silencing Germline-Expressed Genes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Epigenetic Inheritance and Reprogramming in Early Mammalian Development"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Establishment and Maintenance of Specialized Chromatin Domains"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Distinct Architectures of Germ Line and Somatically Expressed Genes"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epigenetic Memory and Maintenance
9:00 am - 9:20 am
"Epigenetic Control of Programmed Genome Rearrangements in Paramecium "
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Domestication of Transposable Elements for Plant Reproduction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Control of Convergently Transcribed Genes Through Modulating Gene-Body Chromatin Modifications"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Super-Enhancer Switching Drives a Burst in Germline Gene Expression at the Mitosis-to-Meiosis Transition"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Biased Fork Movement Coupled with Strand-Specific Histone Incorporation Ensures Asymmetric Histone Inheritance"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Epigenetic Inheritance Independent of Asymmetric Histone Inheritance"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Regulation of Differentiation by Novel Chromatin Remodelers and Promoters"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Biophysics and Mathematical Models
7:30 pm - 7:50 pm
"Polymer Physics Predicts the Impact of Structural Variants on Chromatin 3D Architecture"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Modeling Polycomb-Mediated Epigenetic Silencing"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Kinetics of DNA Maintenance Methylation at Single Molecule Level and Underlying Mechanisms"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"3D Chromatin Organization and Gene Regulation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Antisense-Mediated Chromatin Regulation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Epigenetic Regulation of Sex Determination"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Cellular Heterogeneity in Circadian Oscillation Driven by DNA Methylation and Transcriptional Noise"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"A Role for Epigenetic Reprogramming During Meiosis in Plants"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"H3.3K27M-Induced Chromatin Changes Drive Ectopic Replication Through Misregulation of the JNK Pathway"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Phosphorylation of Histone H3.3 at Serine 31 Promotes p300 Activity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome Function and Disease
7:30 pm - 7:50 pm
"Unexpected Contributors to the Establishment of X Inactivation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"(Epi)genetic Control of Phenotypic Variation and Disease Heterogeneity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mechanisms of Transgenerational Epigenetic Inheritance"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Key Role for HUSH in Triplet-Repeat Silencing in Disease?"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure