Sunday evening, July 29, 8:00 pm

KEYNOTE LECTURE

• Opening/Welcoming Remarks - Tanya Mazur (GRC Site Manager), Steve Heinemann (Chair), and Darrell Brann (Vice Chair)
• Charles Stevens, Salk Institute - "Transmission at excitatory synapses"

Monday morning, June 30, 8:30 am - 12:00 noon

EAA RECEPTORS: Topology & Regulation

• Mary Kennedy, California Institute of Technology, Discussion Leader
• Peter Seeburg, University of Heidelberg - "Mice with genetically altered excitatory neurotransmission"
• Michael Hollmann, Max Planck Inst. - "The significance of N-glycosylation for ionotropic glutamate receptor function"
• Photograph and Coffee Break
• Yael Stern-Bach, Hebrew University - "Pharmacological studies on AMPA and kainate glutamate receptors"
• Mark Mayer, NIH - "Modulation of AMPA Receptors by PEPA: complex physiology of a novel allosteric ligand"

Monday evening, June 30, 7:30 pm - 9:00 pm

EAA RECEPTORS AND POSTTRANSCRIPTIONAL MODIFICATION

• Susan Amara, Oregon Health Sciences University, Discussion Leader
• Gary Westbrook, Oregon Health Sciences University - "Desensitization of recombinant NMDA receptors: how does it compare to native receptors or does it?"
• Richard Huganir, Johns Hopkins University - "Regulation of Glutamate Receptor Function by Protein-Protein Interactions"

Tuesday morning, July 1, 8:30 am - 12:00 noon

EAA RECEPTORS AND SYNAPTIC ORGANIZATION / PLASTICITY

• Amy MacDermott, Columbia University, Discussion Leader
• Mary Kennedy , California Institute of Technology - "Molecular architecture of the glutamatergic postsynaptic membrane."
• Morgan Sheng , Harvard University - "Molecular organization of glutamatergic synapses"
• Coffee Break
• Craig Jahr , Oregon Health Sciences University - "Glutamate transporters rapidly buffer synaptically released glutamate"
• Robert Malenka, UCSF - "Silent synapses in hippocampus and cortex"

Tuesday evening, July 1, 7:30 pm - 9:00 pm

EAAs, LTD AND LTP

• Holis Cline, Cold Spring Harbor, Discussion Leader
• Mark Bear, Brown University - "Bidirectional synaptic plasticity and its regulation in the cerebral cortex"
• Robert Malinow, Cold Spring Harbor - "Silent synapses and plasticity"
• Poster Session 1

Wednesday morning, July 2, 8:30 am - 12:00 noon

EAAs AND SYNAPTIC PLASTICITY

• Robert Malinow, Cold Spring Harbor, Discussion Leader
• Vadim Bolshakov - "Quantal analysis of a late phase of LTP at unitary CA3-CA1 synapses"
• Amy MacDermott, Columbia University - "The painful truth about Calcium permeable AMPA receptors"
• Coffee Break
• Susunu Tonegawa, MIT - "Memory Mechanism"
• Holis Cline, Cold Spring Harbor - "In vivo observations of neuronal form and function"

Wednesday evening, July 2, 7:30 pm - 9:00 pm

EAA TRANSPORTERS AND CELL DEATH

• Timothy Greenamyre, Emory University, Discussion Leader
• Susan Amara, Oregon Health Sciences University - "Excitatory amino acid transporters: a family in flux"
• Dennis Choi, Washington University - "Why are AMPA receptors important in mediating ischemic brain injury?"

Thursday morning, July 3, 8:30 am - 12:00 noon

METABOTROPIC RECEPTORS / HYPOTHALAMIC FUNCTION

• Steve Heinemann, Discussion Leader
• Roger Nicoll, UCSF - "Glutamate receptors and hippocampal function"
• Jeff Conn, Emory University - "Physiological roles and regulation of metabotropic glutamate receptors in the hippocampus"
• Coffee Break
• Darrell Brann, Medical College of Georgia - "Ionotropic and Metabotropic Glutamate Receptors and Hypothalamic Function"
• Sergio Ojeda, OHSU - "Glial and neuronal metabotropic receptors contribute to the cell-cell signaling mechanism that controls hypothalamic neuropeptide secretion"
• Business Meeting
• Poster Session 2

Thursday evening, July 3, 7:30 pm - 9:00 pm

PATHOPHYSIOLOGICAL IMPLICATIONS OF EAAs

• Dennis Choi, Washington Univ., Discussion Leader
• Jim McNarama, Duke University - "Glutamate Receptor Autoantibodies and Rasmussen's Encephalitis"
• Timothy Greenamyre, Emory University - "Excitotoxic-mitochondrial interactions in neurodegeneration"