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|
| Sunday evening | Keynote Lectures |
|
| Chair: P. Seeburg |
| 7:30-8:15 | P. Ascher
Presynaptic NMDA receptors in the cerebellum |
| 8:15-9:00 | S. Nakanishi
Synaptic integrity through excitatory and inhibitory neurotransmissions |
| 9:00-9:45 | S. Heinemann
Genetic dissection of kainate receptor function in synaptic transmission |
| BAR |
| Monday morning | Session 1 GluRs: evolution, structure |
|
| Discussion leader: E. Gouaux |
| 8:45-9:15 | E. Gouaux
The relationships between structure and function in ionotropic glutamate receptors |
| 9:15-9:40 | M. Mayer
Structural similarities between glutamate receptors and bacterial ion channels |
| 9:40-10:05 | D. Madden
Molecular mechanics of glutamate receptors |
| 10:05-10:30 | H. Jingami
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor |
| GROUP PHOTO
BREAK |
| Monday morning | Session 2 GluRs: excitatory synapse: physiology |
|
| Discussion leader: G. Westbrook |
| 11:00-11:30 | G. Westbrook
Use-dependent modulation of NMDA receptors by tyrosine dephosphorylation |
| 11:30-12:00 | C. Jahr
Multivesicular release follows release probability |
| 12:00-12:30 | P. Jonas
Electrical events in presynaptic elements of a glutamatergic hippocampal synapse |
| LUNCH |
| Monday evening | Session 3 Excitatory synapse: ultrastructure, spines |
|
| Discussion leader: P. Somogyi |
| 5:00-5:3- | O. Ottersen
Monocarboxylate transporters at glutamate synapses |
| 5:30-6:00 | R. Wenthold
The role of PDZ proteins in the maturation and trafficking of glutamate receptors |
| 6:00-6:30 | R. Weinberg
Supramolecular architecture of the postsynaptic density |
| 6:30-7:00 | A. Matus
Correlations between motility and morphology in in dendritic spines |
| 7:00-7:30 | K. Harris
Contrasting Effects of Synaptic Activation on Spinogenesis in Immature and Mature Hippocampus |
| DINNER |
| Tuesday morning | Session 4 GluR interactors, synaptic targeting, PSD |
|
| Discussion leader: M. Kennedy |
| 9:00-9:30 | M. Kennedy
Functional implications of multiple protein interactions in the postsynaptic density |
| 9:30-10:00 | M. Sheng
Molecular dynamics at the postsynaptic specialization |
| 10:00-10:30 | D. Bredt
Synaptic regulation of glutamate receptors |
| BREAK |
| 11:00-11:30 | S. Grant
Plasticity pathways: a complex problem |
| 11:30-12:00 | R. Huganir
Regulation of AMPA Receptor Function and Synaptuc Plasticity |
| 12:00-12:30 | A. Craig
Regulated synaptic targeting of NMDA receptors |
| LUNCH |
| Tuesday afternoon | Session 4 continued |
|
|
| 5:00-5:30 | T. Hensch
Signaling synaptic depression and sensory plasticity in developing neocortex |
| 5:30-6:00 | V. Maricq
Genetic dissection of glutamate receptor function in C. elegans: new insights and novel gene products |
| |
| Tuesday evening | Session 5 Imaging |
|
| Discussion leader: R. Tsien |
| 6:00-6:30 | R. Tsien
Genetically encoded indicators of signal transduction and protein proximity |
| 6:30-7:00 | W. Denk
Probing biochemical computation with multi-photon microscopy |
| 7:00-7:30 | A. Fine
Imaging function and plasticity of individual synapses in the hippocampus |
| DINNER |
| Wednesday morning | Session 6 Excitatory synapse: plasticity |
|
| Discussion leader: G. Turrigiano |
| 9:00-9:30 | G. Turrigiano
Synaptic competition in cortical networks |
| 9:30-10:00 | D. Linden
In search of the expression mechanism for cerebellar long-term synaptic depression |
| 10:00-10:30 | M. Bear
Mechanisms of homosynaptic LTD in the hippocampus |
| BREAK |
| 11:00-11:30 | G. Collingridge
Mechanisms involved in hippocampal LTP and LTD |
| 11:30-12:00 | R. Malenka
Mechanisms of NMDAR-dependent LTD |
| 12:00-12:30 | H. Cline
Visual system plasticity: an eye-opening experience |
| LUNCH |
| Wednesday evening | Session 6 continued |
|
|
| 5:00-5:30 | R. Malinow
Subunit-specific rules for AMPA receptor trafficking |
| 5:30-6:00 | T. Bonhoeffer
Activity dependent plasticity: Neurotrophins and morphological changes at the synaptic level |
| 6:00-6:30 | T. SÜdhoff
Control of presynaptic short and long term plasticity by RIM |
| Wednesday evening | Session 7 Kainate receptors |
|
| Discussion leader: R. Nicoll |
| 6:30-7:00 | R. Nicoll
Presynaptic kainate receptors |
| 7:00-7:30 | J. Lerma
Modulation of kainate receptor function |
| DINNER |
| Thursday morning | Session 8 Genetic approaches |
|
| Discussion leader: H. Monyer |
| 9:00-9:30 | H. Monyer
AMPA receptor kinetics in interneurons and synchronous activity between distant pyramidal cells |
| 9:30-10:00 | S. Tonegawa
Roles of CA3 NMDA receptors in memory and memory representation |
| 10:00-10:30 | R. Sprengel
GluR-A and hippocampal LTP expression |
| BREAK |
| 11:30 -12:00 | M. Mishina
GluRd2 and cerebellar function |
| 12:00-12:30 | J. Tsien
Synaptic Reentry-Reinforcement (SRR): a crucial mechanism for memory consolidation |
| LUNCH |
| Thursday afternoon | Session 9 Excitotoxicity |
|
| 5:30-6:00 | D. Choi
Divalent cations and divalent sequelae of glutamate receptor activation |
| 6:00-6:30 | T. Wieloch
Mitochondrial permeability transition mediates excitotoxicity in vivo |
| Thursday evening | Session 9 Excitotoxicity |
|
| Discussion leader: D. Choi |
| 5:30-6:00 | D. Choi
Divalent cations, and divalent sequelae of glutamate receptor activation |
| 6:00-6:30 | T. Wieloch
Mitochondrial permeability transition mediates excitotoxicity in vivo |
| Thursday evening | Session 10 Short talks from hot abstracts |
|
| Chair: R. Huganir |
| 6:30 | Daniel Choquet - CNRS
"Intracellular calcium and synaptic localization
determine AMPA receptor mobility" |
| 6:45 | Jane M. Sullivan - Salk Institute
'Role of conserved aspartate residues within the
C2A and C213 domains of synaptotagmin VII in fast synaptic transmission" |
| 7:00 | K.-Ulrich Bayer - Stanford University
"Interaction with the NMDA receptor
locks CaNWIT in an active state" |
| 7:15 | Katherine Roche - NIH
"Regulation of NNfflA Receptor Endocytosis" |
| 7:30 | Laurent Fagni - CNRS
"Agonist-Independent activation of Group I mGluRs by
Homer proteins in Neurons" |
| 7:45 | Nikolaus J. Sucher - Hong Kong University of Science and Technology
"An N-
methyl-D-aspartate receptor signaling complex with protein phosphatases 2N' |
| 8:00 | DINNER |
