Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: A Multiscale View of the Synapse: From Nanomachines to Circuits and Behavior
7:40 pm - 8:20 pm
"Structure and Mechanism of AMPA Receptors and Their Complexes with Auxiliary Subunits"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Structure, Function and Plasticity of a Central Glutamatergic Synapse"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glutamate Receptor Structure and Dynamics
9:00 am - 9:20 am
"Structure and Organization of Heteromeric AMPA Receptors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structure and Reagents of NMDA Receptors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dynamics and Allosteric Properties of mGluRs: New Possibilities to Control Brain Functions"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Molecular Regulation of AMPA Receptors by Interacting Proteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Biogenesis of AMPARs and Its Impact on Excitatory Neurotransmission and Activity-Dependent Plasticity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structure and Mechanism of an AMPAR-Auxiliary Subunit Complex Without Claudin Homologues"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"New Insights into Excitatory Glycine GluN1/GluN3 NMDA Receptors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Tools and Methodologies to Explore Synaptic Function
7:30 pm - 7:50 pm
"Biochemical Computation in Post-Synapses"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Single Molecule Analysis of Glutamate Receptor Conformational Dynamics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Connectomic Analysis in the Cerebral Cortex"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Getting a Handle on Neuropharmacology by Targeting Receptor Associated Proteins"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Maturation of Excitatory Synapses
9:00 am - 9:20 am
"A Single Phosphorylation Site on the NMDAR GluN2B Subunit Regulates Hippocampal Synaptic Plasticity"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"A Comprehensive Investigation of Human Hippocampal Mossy Fiber Transmission and Plasticity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Sensory Integration in the Visual Thalamus"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Alternative Splice Codes for Neuronal Identity and Synapse Specification"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"How Microglia Prune Specific Synapses in Health and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Ubiquitination at Excitatory Synapses"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Hijacking of a Glutamate Receptor by Inhibitory Synapses"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Scaffolding and Signaling at Excitatory Synapses
7:30 pm - 7:50 pm
"Dynamic Regulation of Postsynaptic Proteins: Insights from Rare Variants"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Regulation of Synaptic Plasticity by Calcium-Permeable AMPA Receptors and Anchored Kinase/Phosphatase Signaling"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Regulation of iGluRs by Extracellular Scaffolding Proteins"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Synaptome in Space and Time"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Experience-Dependent Modulation of Synapses and Circuits
9:00 am - 9:20 am
"Experience and Sleep-Dependent Dendritic Spine Plasticity and Maintenance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Context-Dependent Dynamics of Functional Selectivity in Somatosensory Cortex"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Plasticity of Excitatory Synaptic Transmission Underlying Maladaptive Behavior in Addiction"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Switching Relationships at the Synapse: Neurexins and Its Partners"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Multiple Mechanisms for Synaptic Homeostasis in Visual Cortex"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Experience-Dependent Plasticity in Visual Disability, Recovery and Enhancement"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Excitatory Synaptic Dysfunction and Altered Social Behavior with Overexpression of Schizophrenia-Associated Gene C4"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Synaptopathies: Synaptic Dysfunction in Neuropsychiatric Disorders
7:30 pm - 7:50 pm
"New Implications for Phospho-eIF2alpha-Dependent Protein Synthesis in the Control of Movement"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Cooling Synapses and Neuroprotection"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Plasticity Regulating the Strength of Drug Craving"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Novel Roles for Immune Molecules in Regulating Synapse Formation in Health and Disease"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synaptic Plasticity and Memory
Session in memory of John Lisman.
9:00 am - 9:20 am
"Synaptic Cell Adhesion Proteins and LTP"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Linking AMPA Receptor Dynamics to Synaptic Plasticity and Learning"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"The NMDA Receptor/CaMKII Complex Is the Central Signaling Hub at Excitatory Synapses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of AMPA Receptors in Cognition and Cognitive Disorders"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Synapses in Health and Disease"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Role of KIBRA in Memory: From Molecules to Circuits"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Retrograde Adenosine/A2A Signaling at a Key Excitatory Synapse in the Hippocampus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Signaling Mechanisms at Excitatory Synapses
7:30 pm - 7:50 pm
"Glutamatergic Synaptic Signaling at Rest"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Glutamate Receptosome Dynamics at Excitatory Synapses: Functional Deficiencies in Autism Spectrum Disorders"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Unorthodox NMDA Receptor Signaling in Neocortical Plasticity"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Postnatal Emergence of mTOR-Dependent Protein Translation"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure