Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Physio-Pathological Role of Extracellular Vesicles
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Extracellular Vesicles in Cancer Biology"
8:15 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
"Tissue Injury and Repair"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biogenesis, Composition and Characterization of Extracellular Vesicles
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Triggers for the Release of Extracellular Vesicles from Dendritic Cells"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Monitoring and Facilitating Functional Delivery of Extracellular Vesicle Cargo"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Emerging Themes in the Budding of Proteins, Exosomes and Viruses"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Epstein-Barr Virus LMP1 Hijacks the Host ESCRT-Dependent Cellular Machineries for Exosomal Excretion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Glycine tRNA Halves Are Intrinsically Stable Entities Which Can Be Secreted NON-Selectively in EVs and Incorporated in Recipient Cells in a Homotypic Human Cell Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Vesicles as Delivery Vehicles
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Engineered Extracellular Vesicles in Biomedical Applications"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Extracllular Vesicle Mimetics"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Production and Storage Parameters for Therapeutic Extracellular Vesicles"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Activity-Composition Analysis of MiRNA-Enriched Exosomes"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modulation of Inflammatory Response by Extracellular Vesicles
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"HLSC-Derived EV Modulation of Inflammation and Fibrosis"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Extracellular Vesicles and Transplantation"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Secretion of Extracellular Vesicle Surface-Associated DNA"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Clinical Scale Production of Extracellular Vesicles in a Hollow Fiber Bioreactor"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Development of EV-Based Drug Formulations for Treatment of Neurodegenerative Disorders"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of Extracellular Vesicles in Infectious Diseases
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"HIV-1 Nef Secretion and Extracellular Vesicles"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"The Multiple Faces of Naked Virus-Induced Extracellular Vesicles"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Extracellular Vesicles from Cell-Walled Microbes: Fungi and Gram Positive Bacteria"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Malaria Parasites Regulate Secretion of Exosomes Carrying Distinct Cargo"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Role of Extracellular Vesicles in Cancer Microenvironment and Metastasis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Exploiting Exosomes for Treatment of Cancer"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Extracellular Vesicle MicroRNAs in the Tumor Microenvironment"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Extracellular Vesicles and Cancer Stem Cells"
11:35 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Prostate Cancer Sheds avβ3 Integrin In Vivo Through Exosomes that Are Transferred to Other Cells in the Tumor Microenvironment"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Molecular Subtypes and Differentiation of Glioma Stem Cells as Determinanants of Extracellular Vesicle Profiles and Endothelial Cell Stimulating Activities"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diagnostic and Therapeutic Applications of Extracellular Vesicles
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Dissection of the Heterogeneity of Extracellular Vesicles in Supernatants of Mesenchymal Stem/Stromal Cells"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Imaging and Quantification of Extracellular Vesicles"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Production of Functionally Bioactive Extracellular Vesicles from Immortalized Human Neural Stem Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"A Highly Diverse and Scalable Progenitor Stem Cell Bank for Identifying and Producing Therapeutic Extracellular Vesicles"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Role of Extracellular Vesicles in Neurobiology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Exosome Signaling in Brain Development"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"The Role of Extracellular Vesicles in Neurodegenerative Diseases"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"Defining Exosome Properties for Neuronal Trafficking"
11:35 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"RNA Transfer Across Synaptic Boutons Using Extracellular Vesicles and a Viral-Like Mechanism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Role of Extracellular Vesicles in Stem Cell Biology and Potential Clinical Applications
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 5:50 pm
"Extracellular Vesicles from Potent and Non-Potent Cardiosphere-Derived Cells and from Mesenchymal Stem Cells Elicit Different Immunomodulatory Properties"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:10 pm
"Human Amnion Cell-Derived Extracellular Vesicles in the Treatment of Bronchopulmonary Dysplasia and Associated Pulmonary Hypertension"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:45 pm
"Extracellular Vescicles and Acute Kidney Injury"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:15 pm
General Discussion
7:15 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure