Modes and Mechanisms of Action of Extracellular Vesicles

Understanding the modes and mechanisms in the biology of Extracellular Vesicles (EV) and putting them in the context of physiological and pathological processes in mammalian organisms is essential for their biomedical utilization. EVs may have a huge clinical potential either in biomarker discovery as precise tools for disease monitoring or as EV-based drug candidates being able to modify disease courses. Currently, the lack of a comprehensive knowledge regarding EV biology in health and disease hampers a swift development of potency assays that would be needed in preclinical studies and in the course of clinical assessment.

Confirming the relevance and predictive strength of EV-based disease specific biomarkers on the one hand side as well as the development of disease relevant in vitro and in vivo potency assays to eveluate the therapeutic potential will benefit from a collaborative approach covering broad expertise. This Gordon Research Conference aims to connect expert views from basic discovery providing deep mechanistic insights with the awareness of requirements of biomedical development either in biomarker or therapeutics development. The presentation of cutting-edge technologies providing novel ideas for biomarker discovery or tools for EV-therapeutics manufacturing, bioprocessing and control will be accompanied by a discussion of regulatory aspects as well as specific patient needs in clinical development.