| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Lecture and Emerging Topics |
| Discussion Leader: Saverio Bellusci (Justus-Liebig-Universitaet Giessen, Germany) |
| 7:40 pm - 8:20 pm | Wallace McKeehan (Texas A&M Health Science Center, Houston, USA)
"Celebrating 40 Years of Research in the FGF: Past, Present and Future / FGF: Ubiquitous Regulator of Cellular and Metabolic Hemostasis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Moosa Mohammadi (New York University, USA)
"Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity of FGF Receptors Through Analysis of Pathogenic Gain-of-Function Mutations" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:20 pm | Xiaokun Li (FGF Institute, Wenzhou, PR China)
"Translational Medicine: Development of Fibroblast Growth Factors as Pharmaceuticals in China" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | FGF and Cancer |
| Discussion Leaders: Suzanne Mansour (University of Utah, USA) and Abbie Fearon (Barts Cancer Institute, UK) |
| 9:00 am - 9:25 am | David Ornitz (Washington University School of Medicine, USA)
"Mechanisms of FGF Mediated Protection from Cardiac Injury" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Junchen Liu (Texas A&M Health Science Center, Houston, USA)
"Cross Talk Between FGF and VEGF Signaling Pathways in Prostate Tumor Angiogenesis" |
| 9:45 am - 9:50 am | Discussion |
| 10:00 am - 10:20 am | Coffee Break |
| 10:20 am - 10:45 am | Nora Navone (MD Anderson Cancer Center, USA)
"The Fibroblast Growth Factor Axis in Prostate Cancer" |
| 10:45 am - 10:55 am | Discussion |
| 10:55 am - 11:05 am | Yanqing Huang (Texas A&M Health Science Center, Houston, USA)
"Epithelial Overexpression of FGF9 Promotes Prostate Cancer Progression" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:20 am | Toru Imamura (Natl. Inst. of AIST, Japan)
"Upregulated Expression of FGF13/FHF2 Mediates Resistance to Platinum Drugs in Cancer Cells" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:35 am | Luigi Maddaluno (Inst. for Molecular Health Sciences ETH Zürich, Switzerland)
"FGF-Regulated Genes and Their Roles in Skin Inflammation and Cancer" |
| 11:35 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Xin Zhang (Columbia University, USA)
"Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis" |
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Yongjun Yin (Washington University in St. Louis)
"Dicer1 Loss Reveals a Non-Cell Autonomous Role for FGF9 in the Initiation of Pleuropulmonary Blastoma (PPB)" |
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Raj Ladher (RIKEN Center for Developmental Biology, Kobe, Japan)
"FGFR1 Assembles a Kinocilia-Specific Transport Particle During Inner Ear Hair Cell Specialization" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Role of FGF Signaling in Organogenesis |
| Discussion Leaders: Nora Navone (MD Anderson Cancer Center, USA) and Nandan Nerurkar (Harvard Medical School, USA) |
| 7:30 pm - 7:55 pm | Suzanne Mansour (University of Utah, USA)
"FGF Signaling in Inner Ear Development and Disease" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Olivier Pourquié (IGBMC, France)
"Role of FGF Signaling in the Development of the Musculoskeletal Axis" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:55 pm | Denise Al Alam (Childrens Hospital of Los Angeles, USA)
"Role of FGF10 in Lipofibroblasts Biology During Lung Development and Repair" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Corentin Herbert (Sanofi R&D)
"Small Molecule Allosteric Modulators of FGFs Receptors for the Treatment of Cancer" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Ron Evans (The Salk Institute for Biological Studies, USA)
"A New PPAR - FGF Axis: From Feast to Famine" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 9:40 am | Role of FGF Signaling in Organogenesis (continued) |
| 9:05 am - 9:30 am | Xin Sun (University of Madison, Wisconsin, USA)
"FGF in Lung Development" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 12:30 pm | Role of FGFs in Tissue Regeneration |
| Discussion Leaders: Wallace McKeehan (Texas A&M Health Science Center, Houston, USA) and Elie El Agha (Justus-Liebig-University of Giessen, Germany) |
| 9:40 am - 10:05 am | Bradley Olwin (University of Colorado, Boulder, USA)
"FGR1 Signaling Rescues a Cell-Autonomous Loss of Muscle Stem Cell Function During Aging |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am - 10:35 am | Coffee Break |
| 10:35 am - 11:00 am | Anna Karina Perl (UC Department of Pediatrics Cincinnati, Ohio, USA)
"FGFs Regulate Contractile and Synthetic Fibroblast Function During Compensatory Lung Growth" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Christoph Ladel (Merck Group, Germany)
"SPRIFERMIN (rhFGF18) as Potential Therapeutic for Cartilage Disorders" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:05 pm | Sabine Werner (ETH Zürich, Switzerland)
"Role of FGF Receptor Signaling in Epithelial Repair Processes" |
| 12:05 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Benjamin Almquist (Mass. Inst. of Techology, Mass., USA)
"Combinatorial Growth Factor Therapies for Healing Chronic Skin Wounds" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FGFs at the Crossroads of Other Signaling Pathway |
| Discussion Leaders: Sabine Werner (ETH Zürich, Switzerland) and Junchen Liu (Texas A&M Health Science Center, USA) |
| 7:30 pm - 7:55 pm | Dina Ron (Technion, Haifa, Israel)
"Modulation of Multiple Signaling Pathways by Sef (Similar Expression to FGF): A Developing Story" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Stijn de Langhe (National Jewish Health, USA)
"Lung Stem Cells and Their Niche" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:50 pm | Hongge Li (Columbia University Medical Center, USA)
"PI3K Mediates the Crosstalk Between FGF Signaling and Notch Pathway in Mammalian Lens Development" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:05 pm | Zahra Timsah (MD Anderson, Houston, USA)
"Competition Between Grb2 and Plcγ1 for Binding to FGFR2 Regulates Phospholipase and PTEN Activity, Leading to Cell Invasion and Tumor Formation" |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Jorgen Wesche (Oslo University Hospital, Norway)
"Photoactivation Approaches Reveal a Role for Rab11 in FGFR4 Recycling and Signalling" |
| 9:20 pm - 9:25 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | FGFs, FGFR and Extracellular Matrix |
| Discussion Leaders: Moosa Mohammadi (NYU Langone Medical Center, USA) and Alvaro Ingles-Prieto (Institute of Science and Technology, Austria) |
| 9:00 am - 9:25 am | Chiara Francavilla (University of Copenhagen, Denmark)
"Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Yong Li (University of Liverpool, UK)
"Specificity of Interaction of FGFs and HS" |
| 9:45 am - 9:50 am | Discussion |
| 9:50 am - 10:00 am | Xianqing Mao (Centre de Recherche Public de la Santé, Luxemburg)
"Interactions of Heparan Sulfate and Fibroblast Growth Factor 7 Are Influenced by 3-O-Sulfotransferase 3A in Breast Cancer Cells" |
| 10:00 am - 10:05 am | Discussion |
| 10:05 am - 10:30 am | Coffee Break |
| 10:30 am - 10:55 am | Jeremy Turnbull (University of Liverpool, UK)
"HS Specificity in Regulation of FGF Signalling, and Mechanisms in Nerve Repair" |
| 10:55 am - 11:05 am | Discussion |
| 11:05 am - 11:15 am | Dieter Schams (Technical University of Munich)
"FGFs and Angiogenesis - Important Regulatory Event in Reproduction" |
| 11:15 am - 11:20 am | Discussion |
| 11:20 am - 11:30 am | Nandan Nerurkar (Harvard Medical School, USA)
"FGF-Mediated Mechanical Force Gradients Drive Antero-Posterior Endoderm Cell Flows to Form the Avian Hindgut" |
| 11:30 am - 11:35 am | Discussion |
| 11:35 am - 12:00 pm | David Fernig (University of Liverpool, UK)
"The Evolution of Fidelity of HS Binding in FGFs" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Vaishali Patel (National Institutes of Health)
"Hs3st3-Modified Heparan Sulfate Controls KIT+ Progenitor Expansion by Regulating 3-O-Sulfotransferases" |
| 12:20 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FGFs and Genetic Diseases |
| Discussion Leaders: Anna Karina Perl (Cincinnati Children's Hospital Medical Center, USA) and Regina Irschick (Medical University Innsbruck, Austria) |
| 7:30 pm - 7:40 pm | Cynthia Neben (University of Southern California)
"A Nucleolar Role for FGFR2 in Bent Bone Dysplasia Syndrome" |
| 7:40 pm - 7:45 pm | Discussion |
| 7:45 pm - 8:10 pm | Marja Hurley (University of Connecticut, Farmington, USA)
"Knockout of Nuclear FGF2 Isoforms Modulate Bone and Phosphate Homeostasis" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Lin Chen (Third Military Medical University, PR China)
"The Role of FGFR3 in Skeleton Development and Diseases" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Tom Doetschman (University of Arizona, Tuscon, USA)
"Isoform Specificity of FGF2 Function" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 9:00 am - 12:30 pm | FGFs and Metabolism |
| Discussion Leaders: Richard Grose (University of London, UK) and Chiara Francavilla (University of Copenhagen, Denmark) |
| 9:00 am - 9:25 am | Yang Li (Amgen Inc., USA)
"Endocrine FGFs: Metabolic Action and Therapeutic Development" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:45 am | Michael Blaber (Florida State University, USA)
"Accelerated Dermal Healing by FGF-1 in the NONcNZO10/LtJ Diabetic Mouse" |
| 9:45 am - 9:50 am | Discussion |
| 10:00 am - 10:35 am | Coffee Break |
| 10:35 am - 10:45 am | Tarja Kinnunen (University of Huddersfield, UK)
"C. elegans Model to Asses the Role of FGF/KLB in Metabolism" |
| 10:45 am - 10:50 am | Discussion |
| 10:50 am - 11:05 am | Zamal Ahmed (MD Anderson Cancer Center, Houston, USA)
"The Regulation of FGFR2 Signaling by SH3 Domain Mediated Interactions" |
| 11:05 am - 11:10 am | Discussion |
| 11:10 am - 11:20 am | Cong Wang (Wenzhou Medical University, PR China)
"Hepatocyte FRS2α is Essential for the Endocrine Fibroblast Growth Factor to Limit the Amplitude of Bile Acid Production Induced by Prandial Activity" |
| 11:20 am - 11:25 am | Discussion |
| 11:25 am - 11:50 am | Alexei Kharitonenkov (Lilly Research Laboratories, USA)
"FGF21 Updates" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Jian Xiao (Wenzhou Medical University, PR China)
"bFGF Promoted Human Dermal Fibroblast Migration in the Setting of High Glucose Through PI3K/Akt/JNK and Increased ROS Production" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | B.M. Gayan Indhu Balasooriya (University of Cambridge, UK)
"The Role of Fgfr Signaling in Adult Mouse Lung Stem Cell Regulation" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | FGF Signaling in the Nervous System |
| Discussion Leaders: David Ornitz (Washington University School of Medicine, USA) and Adriana Rodriguez (University of Wisconsin-Madison, USA) |
| 7:30 pm - 7:55 pm | Mohammad Hajihosseini (University of East Anglia, UK)
"Regulation of Hypothalamic Neurogenesis by FGF10" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:10 pm | Niko Hensel (Hannover Medical School, Germany)
"Endocrine FGF23 Acting on Hippocampal Neurons: Impact on Neuronal Morphology and Synapse Formation" |
| 8:10 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:25 pm | James Li (Univ. of Connecticut Health Center, USA)
"Shp2-Dependent ERK Signaling is Essential for Induction of Bergmann Glia and Foliation of the Cerebellum" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Sung-Ho Huh (Washington University School of Medicine, USA)
"Combined Fgf9/20 Signaling is Necessary and Sufficient to Regulate Growth of Cochlear Progenitor Cells" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Lars Klimaschewski (Medical University Innsbruck, Austria)
"Mutants of Fibroblast Growth Factor Receptor 1 Promote Elongative Axon Growth of Sensory Neurons" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Jennifer Quantius (Universities of Giessen & Marburg, Germany)
"Influenza Virus Impairs FGFR2b Dependent Epithelial Regeneration from a Distal Epithelial Progenitor Pool" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Honjun Shi (Victor Chang Cardiac Research Institute, Darlinghurst, Australia)
"Short-Term Gestational Hypoxia Inhibits FGF Signaling in the Embryonic Heart - A Mouse Model of Congenital Heart Disease" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
