Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 8:00 pm
"Chromatin Modification Dynamics During the Activation and Inactivation of Transcription"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Genome Architecture Mapping: Discovering 3D Chromatin Contacts in Rare Cell Types"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Multiplex Chromatin Interactions with Single Molecule Precision"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Development of Single-Cell SPRITE to Comprehensively Map Dynamic Organization of DNA in Higher-Order Nuclear Structures Within Single Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Concepts of Mechanisms for Chromatin Interactions
9:00 am - 9:20 am
"Mapping the Spatial Organization of Genomes Through Data Integration"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Integrative Analysis of Nuclear Genome Compartmentalization"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 10:40 am
"SIP Identifies a Network of Condensin I-DCC Loops"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Variable Nuclear Lamin B1 Interactions with Chromatin During the Circadian Cycle Are Uncoupled from Periodic Gene Expression"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Tandem Directional CTCF Sites Balance Protocadherin Promoter Usage"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Super-Resolution Imaging of Transcription in Live Mammalian Cells"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Local Chromatin Composition Impacts Chromosome Folding Between Distant Genomic Loci"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Deletion of Hdac9 Protein Coding Exons Alters the Transcription Regulation of Twist1 and Results in Limb and Craniofacial Phenotypes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genome Maintenance and Stability
7:30 pm - 7:50 pm
"Multiplexed Probing of the Impact of Chromatin Context on DNA Double-Strand Break Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Control of Human Chromosome Dynamics by ASAR lncRNA Genes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Investigating Factors Involved in Maintaining the 3D Organization of the Human Inactive X Chromosome"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"3D Genome Organization in Cancer"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Topology and Diseases
9:00 am - 9:20 am
"Epigenetic and Transcriptional States of Oligodendrocyte Lineage Cells During Development and in Multiple Sclerosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Investigating H3K27me3-Associated Chromatin Interactions in Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Charting the 3D Epigenomes During Human Corticogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"3D Mapping of Chromatin Organisation in Primary Neuron Progenitors Reveals Cis-Regulatory Functions of the Chromatin Remodeler CHD7"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Long Range Promoter Regulation Revealed by CRISPR/Cas9 Genetic Screen and Capture Hi-C"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Relating Genome Architecture and Transcriptional Regulation by Computational Modeling"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Dynamics of Chromatin Architecture
4:00 pm - 4:20 pm
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:50 pm
"How Cohesin and CTCF Mediate Genome Architecture"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 5:20 pm
"Dynamic Organization of Lamina Associated Domains Through the Cell Cycle"
5:20 pm - 5:30 pm
Discussion
5:30 pm - 5:50 pm
"Chromosome and Genome Dynamics in Pre-Implantation Development"
5:50 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromatin Topology and Transcription
9:00 am - 9:20 am
"CTCFL and Its Impact on Gene Regulation and Interplay with CTCF Function"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Non-Coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Spatial Organization of Transcription"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Role of Mediator and Pol II in Nuclear Architecture"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Regulation of Transcription Through Extremely Long Range Chromatin Interaction in Stem Cells and Cancer"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Characterizing Chromatin Landscape from Aggregate and Single-Cell Genomic Assays Using Flexible Duration Modeling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Satellite Repeat Transcripts Regulate Heterochromatin Organization and Safeguard Chromosome Stability in Mouse Embryonic Stem Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
"Mapping the 3D Genome Organization in Single Cell with the Highly Multiplexing SABER Technology"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Inositol Phosphates Functions in Regulation of Gene Transcription"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Long Range Cis-Acting Functional Interactions: Lessons from Genomic Imprinting"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"TADs Are Ancient Features that Coincide with Metazoan Clusters of Noncoding Conservation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Nup98-Dependent Transcriptional Memory Is Established Independently of Transcription"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Intra-TAD CTCF Occupancy and Antisense Long Noncoding RNAs in Colorectal Cancer"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Chromatin Arranges in Filaments of Blobs with a Nanoscale Functional Zonation Which Becomes Accentuated in Replicative Senescence"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Chromatin Organization During Differentiation and Development
9:00 am - 9:20 am
"The Reprogramming of 3D Chromatin Architecture During Mammalian Embryogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Epigenetic Mechanisms in Early Mammalian Development: Setting up the Nucleus"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:40 am
"Single-Cell DNA Replication Profiling Reveals the Principles of 3D Genome Organization Dynamics at the Megabase Scale"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Is TAD Structure Important for Distal Regulation of the Shh Locus?"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Reprogramming of Chromatin Architecture in Mammalian Gametogenesis and Early Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cohesin Complex Diversity During Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Expanded Potential Stem Cells of Mouse, Human and Pig"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Imaging Chromatin Architecture
4:00 pm - 4:20 pm
"Bridging Microscopy and Genomics Using TSA-Seq to Study Nuclear Organization"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 4:50 pm
"Investigating the Nanoscale Structure and Looping Chromatin in Somatic and Stem Cells"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 5:20 pm
5:20 pm - 5:30 pm
Discussion
5:30 pm - 5:40 pm
"Tracking Epigenetic Modification-Mediated Genome Organization in Living Cells"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Heterogeneity and Intrinsic Variation in Spatial Genome Organization"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure