Sunday
2:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Cell Cycle Dependent Origin Specification by ORC and CDC6"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"From CryoEM Structures to Molecular Mechanisms in DNA Replication"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"The Mechanism of MCM Helicase Loading and Activation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication Fork Stability and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"An Intrinsic S/G2 Checkpoint Enforced by ATR"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Regulation of Template Switching in Response to DNA Damage"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"CMG Ubiquitylation Activates and Regulates Two Interstrand Crosslink Repair Pathways"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:30 am
"Role of RTF2 in Normal Replication and During Replication Stress"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Molecular Functions of the 9-1-1 DNA Damage Response Complex"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Initial Response of a Eukaryotic Replisome to DNA Damage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Maintaining the Integrity of Vertebrate Telomeres"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Structural Biology of Telomere Maintenance"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Stalled Fork Re-Modeller FANCM Represses Recombination Dependent Replication at Human Telomeres"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mechanisms of Break-Induced Telomere Synthesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Extrachromosomal Circular DNA Produce Short Regulatory RNAs that Repress Gene Expression"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Histone Dynamics and Epigenome Maintenance
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Epigenetic Control of Gene Expression and Genome Stability"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Structure and Function of Asf1-Dependent H3K56 Acetylation by Rtt109"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Restoration of Chromatin-Based Information Behind Replication Forks"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"New Insights into Chromatin Replication"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Structural Biology of Histone Chaperones"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Sister Chromatid Availability Directs DSB Repair Pathway Choice via BRCA1-BARD1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
2:00 pm - 4:00 pm
Poster Session
4:00 pm - 6:00 pm
Chromosomal Architecture and Stability
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:30 pm
"BRCA1 and H3K9 Methylation Cooperate to Stabilize Repetitive DNA"
4:30 pm - 4:40 pm
Discussion
4:40 pm - 4:50 pm
"Studying the Unconventional Nucleolar Response to DNA Double Strand Breaks"
4:50 pm - 4:55 pm
Discussion
4:55 pm - 5:05 pm
"DNA Primary Sequence/Secondary Structure Contributes to DNA Fragility"
5:05 pm - 5:10 pm
Discussion
5:10 pm - 5:20 pm
"Carcinogen Susceptibility Is Regulated by Genome Architecture and Predicts Cancer Mutagenesis"
5:20 pm - 5:25 pm
Discussion
5:25 pm - 5:35 pm
"NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis"
5:35 pm - 5:40 pm
Discussion
5:40 pm - 5:50 pm
"E3 Ubiquitin Ligase Bre1 Couples Sister Chromatid Cohesion Establishment to DNA Replication"
5:50 pm - 5:55 pm
Discussion
5:55 pm - 6:00 pm
General Discussion
6:00 pm - 7:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Rigidity and Dynamics of Mammalian Rad50 in DNA Double Strand Break Repair"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"BRCA1 Ensures Genome Integrity by Eliminating Estrogen-Induced Pathological Topoisomerase II-DNA Complexes"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
"RNF169 Limits 53BP1 and RAP80 Deposition at DSBs to Stimulate Single-Strand Annealing Repair"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"The Smc5/6 Complex Suppresses Genome Instability Through Regulation of Replication Restart"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Kinase Control of DNA Repair and Genome Stability"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"53BP1 Cooperation with the Rev7-Shieldin Complex Underpins DNA Structure-Specific NHEJ"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"The Essential Function of the Histone Chaperone Asf1 in Fission Yeast"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Proteomic Analysis of DNA Damage Response and Tumorigenesis"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"New Functions of ATR in Suppressing Genomic Instability"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Novel Role of FANCA in DNA Double Strand Break Repair"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genome Instability and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Homologous Recombination Deficiency and Replication Stress"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"The DNA Damage Response: New Branches and a New Overlook"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Rad52 Promotes XPG-Mediated R-Loop Processing to Initiate Transcription-Coupled Homologous Recombination Repair"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Genome Instability in the Human Germline"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Novel Insights into DNA Double Strand Break Repair"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"SIRT6 Is a Novel DSB Sensor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Targeting Genome and Epigenome Maintenance in Cancer
4:00 pm - 4:05 pm
Introduction by Discussion Leader
4:05 pm - 4:30 pm
"Targeting Replication Stress Response Dependencies to Generate New Cancer Therapies"
4:30 pm - 4:40 pm
Discussion
4:40 pm - 5:05 pm
"The Roles of the Linker Histones in Response to DNA Damage"
5:05 pm - 5:15 pm
Discussion
5:15 pm - 5:25 pm
"A Novel SWI/SNF Chromatin Remodeling Complex Inhibitor Synergizes with ATR Inhibition in Cancer"
5:25 pm - 5:30 pm
Discussion
5:30 pm - 5:40 pm
"XRCC2-Mediated Coordination Between dNTP Alterations and Replication Fork Progression Safeguards Genome Integrity"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"EZH2 Mediates Cisplatin Resistance in Small Cell Lung Cancer Through Nucleotide Excision Repair"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure