Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Germline Specification and Pre-Specification Events
Discussion Leader: Mitinori Saitou (Kyoto University, Japan)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Katsuhiko Hayashi (Osaka University, Japan)
"Reconstitution and Manipulation of Gametogenesis Using Mouse Pluripotent Stem Cells"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Shankar Srinivas (University of Oxford, United Kingdom)
"Specification and Morphogenesis of Germ Layers during Early Mouse and Human Embryogenesis"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Short Talk Selected from Poster Abstracts
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
Short Talk Selected from Poster Abstracts
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Azim Surani (University of Cambridge, United Kingdom)
"Germline-Imprinting Cycle in Mammalian Evolution and Development"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthetic Primate Embryology
Discussion Leader: Monika Ward (University of Hawaii, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ge Guo (University of Exeter, United Kingdom)
"Studying Early Embryo Development Using Human Naïve Pluripotent Stem Cells"
9:30 am - 9:35 am
Discussion
9:35 am - 9:55 am
Kyle Orwig (University of Pittsburgh, United States)
"Are Stem Cell Therapies for Male Infertility Ready for the Clinic?"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Short Talk Selected from Poster Abstracts
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Amander Clark (University of California, Los Angeles, United States)
"Principles of Germ Cell Specification Using In Vitro Gametogenesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Paula Cohen (Cornell University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ethics of Synthetic Biology and Genome Editing
Discussion Leader: James Turner (The Francis Crick Institute, United Kingdom)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Misao Fujita (Kyoto University)
"An Initiative towards Establishing Guidelines for Fetal Tissue Research in Japan"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Insoo Hyun (Museum of Science; Harvard Medical School)
"How Bioethics Can Facilitate Research, Not Hinder It"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Robin Lovell-Badge (The Francis Crick Institute, United Kingdom)
"In Vitro-Derived Gametes and Heritable Genome Editing – Scientific and Ethical Minefields"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:35 pm
Short Talk Selected from Poster Abstracts
7:35 pm - 7:40 pm
Discussion
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Silencing Events in the Germline
Discussion Leader: Jon Oatley (Washington State University, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Satoshi Namekawa (University of California, Davis)
"Chromatin-Based Mechanisms for the Long Maintenance of Germinal Stem Cells"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Short Talk Selected from Poster Abstracts
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Bernhard Payer (Centre for Genomic Regulation (CRG), Spain)
"The CompleX Story of How and Why to Turn a Chromosome OFF and ON again"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Paula Cohen (Cornell University, United States)
"Unexpected Roles for Mammalian Argonautes in Orchestrating Meiotic Sex Chromosome Inactivation"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Signals to the Germline
Discussion Leader: Josephine Bowles (The University of Queensland, Australia)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Diana Laird (University of California, San Francisco, United States)
"Heterogeneity in the Developing Germline"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Tessa Lord (University of Newcastle, Australia)
"Establishing a Relationship between Hypoxia and Spermatogonial Stem Cell Identity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Short Talk Selected from Poster Abstracts
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Shosei Yoshida (National Institute for Basic Biology, Japan)
"Barcoding the Mouse Male Germline to the Next Generation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Environmental Effects on Epigenetic Programming
Discussion Leader: Patrick Allard (University of California, Los Angeles, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Sarah Kimmins (University of Montreal, Canada)
"The Role of the Sperm Epigenome in Embryo Development and Disease Inheritance"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Short Talk Selected from Poster Abstracts
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
Folami Ideraabdullah (University of North Carolina at Chapel Hill, United States)
"Role of Maternal Micronutrient Availability in Programming the Male Germline Epigenome"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Short Talk Selected from Poster Abstracts
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Wei Xie (Tsinghua University, China)
"Decoding the Transcription Circuitry in Early Mammalian Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Meiosis
Discussion Leader: Jesus Page (Universidad Autonoma de Madrid, Spain)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Peter Fraser (Florida State University, United States)
"3D Genome Organization of Male Gametogenesis at the Single Cell Level"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Devanshi Jain (Rutgers University, United States)
"Regulation of Meiotic Entry and Progression"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Short Talk Selected from Poster Abstracts
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Bernard de Massy (Institute of Human Genetics CNRS UMontpellier, France)
"Chromosome Organization for Meiotic Recombination"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
RNA Metabolism and Translational Control
Discussion Leader: Victor Ruthig (Weill Cornell Medicine, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Miguel Ramalho-Santos (Lunenfeld-Tanenbaum Research Institute and University of Toronto, Canada)
"RNA Methylation Orchestrates Transcriptional Dormancy during Mammalian Developmental Pausing"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
Short Talk Selected from Poster Abstracts
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Short Talk Selected from Poster Abstracts
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Mofang Liu (Mofang Liu, PI, Shanghai Institute of Biochemistry and Cell Biology, CAS, China)
"The New Functions of RNA Regulation in Male Germ Cells and Human Male Infertility"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Jon Oatley (Washington State University, United States)
"Developmental Specification of a Reserve Stem Cell Pool in the Male Mouse Germline"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Donal O’Carroll (University of Edinburgh)
"piRNA-Directed DNA Methylation in the Developing Germline"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mutation and Aneuploidy in the Germline
Discussion Leaders: Ignasi Roig (Universitat Autònoma de Barcelona, Spain)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Melina Schuh (Max-Planck-Institut für Multidiziplinäre Naturwissenschaften, Germany)
"Illuminating the Beginning of Life"
6:30 pm - 6:35 pm
Discussion
6:35 pm - 6:55 pm
Eva Hoffmann (University of Copenhagen, Denmark)
"Mechanisms of Aneuploidy and DNA Repair in the Human Germline"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Short Talk Selected from Poster Abstracts
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Aurora Ruiz-Herrera (Universitat Autonoma Barcelona, Spain)
"3D Chromatin Remodeling in the Germ Line"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure