Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Interdisciplinary Glycosciences
Three lectures addressing tools and future perspectives.
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Genetic Code Asymmetry Supports Diversity Through Experimentation with Posttranslational Modifications"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Discovery and Analysis of New Glycoenzyme Activities"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Targeting Cancer Associated O-Glycosylation"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Building Glycan Complexity: Structural Insights
9:00 am - 9:20 am
"Interactions Between GPI-Anchor Biosynthesis and Glycosphingolipid Biosynthesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structural Basis of Glycogen Biosynthesis Regulation in Bacteria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Structural Insight into Eukaryotic Oligosaccharyltransferase"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural Basis of Nucleotide Sugar Transport Across the Golgi Membrane"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Clinical Glycome Deep-Sequencing to Decipher the Glyco-Language of Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Spatial Glycan Localization of the Mammalian Brain Using MALDI Imaging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Immunological Development of Antibodies to Carbohydrates"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Chemical Ways to Complex Glycans"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Explore the Promiscuity of Glycosylation Enzymes to Boost the Efficacy of Cancer Immunotherapy"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"NMR Experiments Identify Allosteric Networks and a Posttranslational Modification in a Human Norovirus Coat Protein"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Processes Controlled by Glycans and Lectins
9:00 am - 9:20 am
"Recombinant and Engineered Lectins for Research and Diagnostics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Lectin-Driven and Glycosphingolipid-Dependent Construction of Endocytic Pits"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Sialobiology Is Intimately Involved in the Majority of Human Infectious Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Assigning Proteoglycan Site-Specific Glycosylation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Role of C -Mannosylation in Protein Folding and Stability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Structural Basis for Mammalian Nucleotide Sugar Transport"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Dynamic Protein Modification by O -GlcNAcylation
6:00 pm - 6:20 pm
"Nutrient Regulation of Gene Expression and Cell Signaling"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mapping and Manipulating O -GlcNAc During Immunoactivation"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Chemical Biology Approaches for Studying O -GlcNAc"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Regulation of Nuclear Transcription Factors by a Novel Interplay Between Posttranslational O-Fucosylation and O-GlcNAcylation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycosyltransferases and Glycobioinformatics
9:00 am - 9:20 am
"Identification and Characterization of Two Novel Protein O -Glucosyltransferases"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Molecular Basis of GalNAc-Ts Substrate Specificity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Glycosylation in Giant Viruses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Omics Data Integration Efforts Leading to Applications in Medicine, Energy, Nutrition and the Environment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Glyco(proteo)mics Goes Visual, Interactive and Analytical"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Sequence-to-Structure Dependence of Isolated IgG Fc Complex Biantennary N-Glycans: A Molecular Dynamics Study"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Highly Efficient and Precise Glycoproteomic Analysis with Intelligent Technology"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Glycans in Oncodevelopment
6:00 pm - 6:20 pm
"Regulation of Glycosylation Related Enzymes in Tumor Biology"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Galectins: What Is Their Message from the Bone Marrow Microenvironment to Leukemia Cells?"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Glycosylation at the Interface of Inflammation and Cancer: Mechanisms and Clinical Implications"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"O-GlcNAc Inhibits FGF4 Signaling via Inhibition of PKC-Zeta Phosphorylation to Maintain Naïve State in Mouse Embryonic Stem Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Glycans in Ontodevelopment and Immunology
9:00 am - 9:20 am
"Glycan Recognition by Myeloid Cells in the Tumor Microenvironment"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Role of Siglecs and Sialic Acids in the Regulation of Immune Cell Functions"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Shaping the Immune Landscape by Galectin-Driven Regulatory Circuits: Therapeutic Opportunities in Cancer, Autoimmunity and Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Sialic Acid Is the Fetal Line of Defense Against Maternal Complement Attack"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Drosophila melanogaster : A Model to Study Glycosylation Disorders"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Naturally Occurring O-Glycans Regulate Activity and Stability of Peptide Hormones"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Glycan Markers of Human Stem Cells Assigned with Beam Search Arrays"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Biotechnological Perspectives
6:00 pm - 6:20 pm
"GlycoLiverProfile: The First Diagnostic Glycomics Biomarker Reaches the Clinic. A 15-Year Journey"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Glycosaminoglycan Engineering: Chemoenzymatic Synthesis of Heparosan- and Hyaluronan-Based Polymers"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Glycoengineering in the Baculovirus-Insect Cell System"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Plant Based Glycan Engineering and Functional Activities of IgE and IgA Antibodies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure