Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Session in Memory of Mark Kester: Sphingolipids and Glycosphingolipids in Physiology and Disease
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"S1P Lyase: From Gene Discovery to Gene Therapy and Beyond"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Analysis of Sphingolipids and Glycosphingolipids
9:00 am - 9:20 am
"Dysregulation of (Glyco)sphingolipids in Pancreatic Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Unlocking the Diversity of Glycolipids Using Lipidomic Tools: From Bacteria, to Plants and Mammals"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Perturbed Myelin Sphingolipid Metabolism in the Etiology of Alzheimer’s Disease and Frontotemporal Dementia"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"CRISPR-Mediated Advancements in Sphingolipid Metabolism Disorders: Disease Modeling and Therapeutic Innovations"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Unravelling Neuronal and Glial Differences in Ceramide Composition, Synthesis, and Sensitivity to Toxicity"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Glucosylated Cholesterol Accumulates in Atherosclerotic Lesions: Friend or Foe?"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Deletion of Glucocerebrosidase in Neurons, but Not Microglia, Causes Sphingolipid Accumulation, Neuroinflammation, and Neurodegeneration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Biosynthesis of Sphingolipids and Glycosphingolipids
7:30 pm - 7:50 pm
"Cross Talk Between Different Cell Populations in Myelin Repair: Sphingolipids Conduct the Orchestra"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Neutral Sphingomyelinase Activity is Present in Hepatic Lipid Droplets and has a Role in Droplet Biogenesis and Metabolism"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sphingolipids and Asthma"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"In Vivo Base Editing of the Common Amish Mutation That Causes GM3 Synthase Deficiency"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Synthesis of a GM1 Structural Library Reveals Distinct Membrane and Trafficking Behavior Based on Ceramide Structure"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Metabolism and Trafficking of Sphingolipids and Glycosphingolipids
9:00 am - 9:20 am
"Mechanistic Insights into Lysolipid Transport in the Lysosomes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"ER-Golgi Contact Sites: Regulators and Targets of Sphingolipids"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Role of Sphingolipids in Acute Kidney Injury and Progression to Chronic Kidney Disease"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"SPTLC3 and Unusual Sphingolipids as Inducible Metabolic Modulators"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Ceramide Signaling at the Plasma Membrane"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Transmembrane Signaling of GPI-Anchored NB-3/Contactin-6 via Src-Family Kinase Yes in Ganglioside GD1b Rafts of Cerebellar Granule Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Simple Glycosphingolipids are Required for NK Cell Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Function of Sphingolipids and Glycosphingolipids
7:30 pm - 7:50 pm
"Rewiring Sphingolipid Signaling in Cardiometabolic Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Lipid Dysregulation Pinpoints Candidate Therapeutic Targets for Parkinson’s Disease"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Transcriptional Network Governing Ceramide Homeostasis Establishes a Cytokine-Dependent Developmental Process"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Influence of CerS3 on Lipid Raft Formation and Function in T Cells"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"In Vivo Base Editing of the Human Late-Onset Tay-Sachs Disease Mutation Ameliorates Neurodegeneration"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sphingolipids and Diseases
9:00 am - 9:20 am
"Roles of Sphingolipid Metabolism in the Regulation of Anti-Tumor Functions of T-Cells and Immunotherapy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Sphingolipids in Chemotherapy-Induced Neurotoxicity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Brain Gangliosides: Old Dogs With New Tricks"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Measuring Sphingolipid Fluxes and the Impacts of Substrate Diversity on Metabolic Disease Co-Morbidities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Diabetic Retinopathy is a Ceramidopathy Reversable by Systemic Anti-Ceramide Immunotherapy"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Targeting the Sphingolipid Pathway in IDH1mut Glioma Alters Cholesterol Homeostasis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Fenretinide is a Novel Targeted Therapy for M6 and M7 Acute Myeloid Leukemia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycosphingolipids and Diseases
7:30 pm - 7:50 pm
"The Complexity of Secondary Sphingolipid Storage Disorders: Insights From Niemann-Pick Disease Type C"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Positive and Negative Roles of Ceramide and its Metabolites as Lipid Mediators in Skin"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Linking Glycosphingolipid Imbalances to Changes in the Plasma Membrane Proteome: New Mechanisms Driving Neurodegeneration"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Amyloid-Like Fibrils of the GlcCer Sphingolipid Occur in Gaucher Disease Patient Cells and Cross-Seed aSyn Aggregation, Suggesting a Mechanism Linking of Parkinson's and Gaucher Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Gangliosides, a Novel Paradigm for the Management of Childhood Brain Tumors"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Latest Discoveries in Glycolipid and Sphingolipid Biology
9:00 am - 9:20 am
"Imaging Isomeric Glycolipids in Mouse Brain by Robotic Liquid Extraction Surface Analysis in Combination With LC/MS"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Effect of Sphingomyelin Synthase-Related Protein (SMSr), as a Phosphatidylethanolamine Phospholipase C (PE-PLC), on Nonalcoholic Fatty Liver Disease (NAFLD)"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Structural and Functional Characterization of the Yeast Ceramide Synthase"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Genotype-Phenotype Correlations in CerTra Syndrome"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Dissection of Lipid Metabolism Dysregulation in a Novel Mouse Model of Lysosomal Free Sialic Acid Storage Disorder"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Identification of Tumor-Marker Gangliosides for Early Cancer Detection: A Multi-Platform Approach"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sphingolipids and Glycosphingolipids in Yeasts, Bacteria and Parasites
7:30 pm - 7:50 pm
"Unique Features of Entamoeba Sphingolipid Metabolism: Very Long Chain Dihydroceramides Confer Dormancy to Entamoeba Parasites"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Sphingolipid Synthesis and the Pathophysiology of Porphyromonas Gingivalis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sphingolipid Metabolism in the Protozoan Parasite Leishmania"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Inhibition of Sphingosine Kinase Disrupts Symbiosis of Two Cnidarian Model Systems"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Convergent Evolution of Bacterial Sphingolipid Synthesis"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure