Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: (Glyco)Sphingolipid Synthesis and its Inborn Errors
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:35 pm
"Regulation of Serine Palmitoyltransferase: an Elegant Vulnerability?"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Non-Vesicular Ceramide Trafficking at Organelle Contact Sites: A Research Journey"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
(Glyco)Sphingolipids: Key Players in Cellular Processes
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"Molecular Mechanisms of Regulating Sphingolipid Metabolism in the ER"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Glucosylceramide Controls ER-TGN Contact Sites"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Lipid Asymmetry: Costs and Benefits"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Targeted Degradation of CERT1 with Small Molecule Chimeras Directed to the 26S Proteasome"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Glyco)Sphingolipids as Architects of Multicellular Organization
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"Role of Lipids in Regulating Differentiation of Human Epidermal Stem Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"GlycoSwitch: A Novel Signaling Circuit to Control GlycoLipid-Lectin (GL-Lect) Driven Endocytosis"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"LIpid Territories as Tissue-Scale Coordinator of Intestinal Morphogenesis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Molecular and Membrane Factors Driving Endosome Sorting of the Complex Sphingolipids"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
(Glyco)Sphingolipids in Immune Recognition
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"The Lipid Gb3 in Type I Interferon Receptor Assembly and Autoimmunity"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Decoding the Immunological Lipidome"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Sphingolipids and Inflammation in Normal and Malignant Human Hematopoiesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"The Seesaw of Sphingolipids in Pancreatic Beta-Cells"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Glyco)Sphingolipids in Cancer Immune Recognition
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"Modulating Very Long Chain Fatty Acid Elongation to Kill Cancer Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Understanding the Role of Phospholipid Metabolism in Cancer"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"MDM4 Inhibition Reprograms Sphingolipid Metabolism to Restore Melanocytic Differentiation and Potentiate Immunotherapy in Melanoma"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
Short Talk Selected from Poster Abstracts
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Short Talk Selected from Poster Abstracts
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
(Glyco)Sphingolipids in Neurodevelopment
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"Sphingomyelin-Induced Pathological Crosstalk Between Neurons and Glial Cells in Lysosomal Storage Disorders"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"The Neuronal Ceroid Lipofuscinoses: Genetics, Apoptosis and Sphingolipids, Neurodegeneration and Therapies in CLN3 and CLN6 Mouse Models"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Targeting Sphingolipid Metabolism in Gliomas"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Unravel the Role of S1P in Central Myelination During Development and Repair"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Short Talk Selected from Poster Abstracts
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Glyco)Sphingolipids in Neurodegeneration
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"Emerging Insights into the Role of CERT in Brain Function and Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Sphingolipids in Huntington's Disease: Pathological Mechanisms and Potential Therapies"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Decoding the Sphingolipid Quality Control Axis in Neuron Degeneration"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Microglia-Neuron Crosstalk via Hex-GM2-MGL2 Maintains Brain Homeostasis"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
(Glyco)Sphingolipids in Physiology
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"S1P Signaling in Blood Pressure Homeostasis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"The Silent Lipids: How Ceramides Shape the Heart’s Fate"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Ceramide Synthase-6 as a Target for Cardiometabolic Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Lipid Remodeling During Infection"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"Probing the Ganglioside-Protein Interactome"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Short Talk Selected from Poster Abstracts
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Breakthrough Technologies in (Glyco)Sphingolipid Research
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"The Lipidomic Architecture of the Mouse Brain"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Tracking Lipids Through Chemical and Physical Space"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Functional Sphingolipids to illuminate Mechanisms of Infectious Diseases"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Federated Lipidomics of Human Blood Plasma"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure