Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: (Glyco)Sphingolipid Synthesis and its Inborn Errors
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 8:35 pm
"Regulation of Serine Palmitoyltransferase: An Elegant Vulnerability?"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Non-Vesicular Ceramide Trafficking at Organelle Contact Sites: A Research Journey"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
(Glyco)Sphingolipids: Key Players in Cellular Processes
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"Molecular Mechanisms of Regulating Sphingolipid Metabolism in the ER"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Glucosylceramide Controls ER-TGN Contact Sites"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Lipid Asymmetry: Costs and Benefits"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Molecular and Membrane Factors Driving Endosome Sorting of the Complex Sphingolipids"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Disease-Causing Mutations in the KDSR Gene Directs Sphingolipid Metabolism into Chemically-Reactive Metabolites"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Atomistic Model for Cholesterol-Sphingolipid Interactions"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Secreted Ceramide by Irradiated Endothelial Cells Enhance Mammary Tumor Senescence to Radiotherapy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Expanding the Genetic and Functional Landscape of Ceramide Transporter (CerTra) Syndrome"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Glyco)Sphingolipids as Architects of Multicellular Organization
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"Role of Lipids in Regulating Differentiation of Human Epidermal Stem Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"GlycoSwitch: A Novel Signaling Circuit to Control GlycoLipid-Lectin (GL-Lect) Driven Endocytosis"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Tracking Lipids Through Chemical and Physical Space"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Targeted Degradation of CERT1 with Small Molecule Chimeras Directed to the 26S Proteasome"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
(Glyco)Sphingolipids in Immune Recognition
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"Ceramide Synthase-6 as a Target for Cardiometabolic Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"The Lipid Gb3 in Type I Interferon Receptor Assembly and Autoimmunity"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Decoding the Immunological Lipidome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Sphingolipids and Inflammation in Normal and Malignant Human Hematopoiesis"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
"The Seesaw of Sphingolipids in Pancreatic Beta-Cells"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"A Sphingomyelin-Sensing Pathway Governing Metabolic Inflammation"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Intracellular Sulfatides Trigger the Non-Canonical and the Canonical NLRP3 Inflammasomes"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Glyco)Sphingolipids in Cancer Immune Recognition
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"Modulating Very Long Chain Fatty Acid Elongation to Kill Cancer Cells"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Understanding the Role of Phospholipid Metabolism in Cancer"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Targeting Ceramide Metabolism in Melanoma to Improve Efficacy of Immune Checkpoint Inhibitor Therapy: From Basic Mechanisms to the Clinic"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Dihydroceramide Desaturase 1 (DES1)–Caspase 14 Axis Drives Anchorage-Independent Survival and Metastasis in HER2+ and Basal Breast Cancer"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Immunometabolic Reprogramming in MASH-HCC: Sphingolipid-Mediated Regulation of the Tumor Microenvironment"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
(Glyco)Sphingolipids in Neurodevelopment
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"Sphingomyelin-Induced Pathological Crosstalk Between Neurons and Glial Cells in Lysosomal Storage Disorders"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"The Neuronal Ceroid Lipofuscinoses: Genetics, Apoptosis and Sphingolipids, Neurodegeneration and Therapies in CLN3 and CLN6 Mouse Models"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Targeting Sphingolipid Metabolism in Gliomas"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Unravel the Role of S1P in Central Myelination During Development and Repair"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Ceramide Phosphoethanolamine in Membrane Biology: From Spermatogenesis to Epilepsy"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Loss of Glial Ceramide Synthase Schlank Links Autophagic Flux to Impaired Neurotransmitter Homeostasis and Seizures"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"How Glycosphingolipids Influence the Functional Identity of Brain Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Quantitative Imaging and Characterization of Brain Ganglioside Phenotypes in Parkinson’s Disease"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Glyco)Sphingolipids in Neurodegeneration
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"Emerging Insights into the Role of CERT in Brain Function and Disease"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Sphingolipids in Huntington's Disease: Pathological Mechanisms and Potential Therapies"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
"Decoding the Sphingolipid Quality Control Axis in Neuron Degeneration"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Microglia-Neuron Crosstalk via Hex-GM2-MGL2 Maintains Brain Homeostasis"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
(Glyco)Sphingolipids in Physiology
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:30 am
"S1P Signaling in Blood Pressure Homeostasis"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"The Silent Lipids: How Ceramides Shape the Heart’s Fate"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Lipid Remodeling During Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Functional Sphingolipids to Illuminate Mechanisms of Infectious Diseases"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Mechanistic Constraints in Ceramide LC-MS/MS Quantification: From in-Source Chemistry to Quantitative Bias"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Lipid Research Boundaries: New Chemical Tools and Approaches to Disease"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Cholesterol Depletion Activates Trafficking-Coupled Sphingolipid Synthesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Breakthrough Technologies in (Glyco)Sphingolipid Research
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:30 pm
"The Lipidomic Architecture of the Mouse Brain"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Lipid Territories as Tissue-Scale Coordinator of Intestinal Morphogenesis"
6:55 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
"Automated Transition List Generation for Glycosphingolipid and Ceramide Mass Spectrometry"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Short Talk Selected from Poster Abstracts
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
Short Talk Selected from Poster Abstracts
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure