Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Methodological Breakthroughs with Heterocyclic Compounds
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"Catalytic Alkene Functionalization for Heterocycle Synthesis and Derivatization"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Calcium Catalysed Generation and Utilization of Reactive Intermediates"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"C-H Functionalization of Heterocycles by Cooperative Catalysis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterocycles in Complex Molecule Synthesis
9:00 am - 9:35 am
"Synthesis of Bioactive Heterocyclic Natural Products"
9:35 am - 9:45 am
Discussion
9:45 am - 10:20 am
"Regiospecific Syntheses and Reactions of Aromatic Molecules"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"3D Hetero-Spirocycles: Synthesis and Application"
11:15 am - 11:25 am
Discussion
11:25 am - 12:00 pm
"Total Synthesis of Polycyclic Indole Alkaloids Enabled by Skeletal Reorganization"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis in Heterocyclic Contexts
7:30 pm - 8:00 pm
"Harnessing Non-Covalent Interactions to Address Selectivity Challenges in Catalysis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Stereoselective Alkene Functionalization via Radical Pathways"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Organophosphorus-Catalyzed Methods Based on P(III)/P(V) Redox Cycling"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 12:30 pm
Free Time
12:30 pm - 1:30 pm
Lunch
1:30 pm - 5:00 pm
Heterocycles as a Platform for Advances in Synthesis
1:30 pm - 2:00 pm
"Stereoselective Functionalization of Unsaturated Hydrocarbons"
2:00 pm - 2:10 pm
Discussion
2:10 pm - 2:35 pm
"Isotope and Medicinal Chemistry Late Stage Functionalizations in Drug Discovery"
2:35 pm - 2:45 pm
Discussion
2:45 pm - 3:15 pm
Coffee Break
3:15 pm - 3:30 pm
"Biomimetic Synthesis of Hitorins A and B"
3:30 pm - 3:40 pm
Discussion
3:40 pm - 4:05 pm
"Mechanistic Studies on the Unexpected Racemization of Cyclopropyl Isoxazolines"
4:05 pm - 4:15 pm
Discussion
4:15 pm - 4:50 pm
"New Strategies for the C-H Functionalization of Amines"
4:50 pm - 5:00 pm
Discussion
5:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inventions in Heterocycle-Based Functionalization
7:30 pm - 8:05 pm
"Engaging Challenging Substrates in Cross-Electrophile Coupling"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Atropisomerism as a Tool in Drug Discovery and an Inspiration for New Chemistry"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Asymmetric C-H Oxidations"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Route Development and Optimization to Bioactive Heterocycles
9:00 am - 9:30 am
"Synthetic Route Development Utilizing a C-N Cross-Coupling Approach for a Drug Candidate"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Diastereoselective Pictet-Spengler Based Synthesis of a D1 Potentiator"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Commercial Route Development of Daurismo (Glasdegib), a SMO Inhibitor"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Process Development Enables the Synthesis of a Complex Macrocyclic Peptide Antibiotic"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Methods Toward Heterocyclic Compounds
7:30 pm - 8:00 pm
"Allylic Azides: Harnessing the Winstein Rearrangement Through DKR"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Beyond Cp*: Mechanism Driven Development of a New Rhodium Complex for Enantioselective C-H Functionalization"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Donor-Acceptor Cyclopropanes as Masked 1,3-Dipoles for the Synthesis of Heterocyclic Compounds"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Interplay of Heterocyclic Compounds and Biological Inquiries
9:00 am - 9:30 am
"Biocatalysis and Complex Molecule Synthesis"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Discovery and Synthesis of AZD4573, a Potent and Selective CDK9 Inhibitor"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Rapid Discovery of Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Discovery of Tetflupyrolimet: A New Mode-of-Action Herbicide Interfering with De Novo Pyrimidine Biosynthesis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Synthetic Transformations via C-H Bond Functionalization"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Prospects in Heterocyclic Chemistry: Synthesis and Related Studies
7:30 pm - 8:10 pm
"Recent Efforts in the Synthesis of Complex Natural Products"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 9:05 pm
"Synthetic, Bioorganic and Medicinal Chemistry in the Smith Group"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure