Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
 
 
						
7:40 pm - 9:30 pm 
	
Strategic Approaches to the Preparation of Heterocyclic Natural Products 
 
 
 
						
7:40 pm - 7:45 pm 
	
Opening Remarks
 
 
						
7:45 pm - 8:15 pm 
	
"Pyrrolo[3,2-b]pyrroles - Electron-Rich Functional Heterocycles" 
 
 
 
						
8:15 pm - 8:25 pm 
	
Discussion
 
 
						
8:25 pm - 8:55 pm 
	
"Functionalized Oxacycles as Progranulin Enhancers" 
 
 
 
						
8:55 pm - 9:05 pm 
	
Discussion
 
 
						
9:05 pm - 9:20 pm 
	
"Reactivity of Sulfonylcyclopropanols as Precursors of Amide Homoenolates and Fused Heterocycles" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
New Approaches to Heterocyclic Compound Construction 
 
 
 
						
9:00 am - 9:30 am 
	
"Synthesis and Bioactivity of 2,3-Diaryl-1,3-thiaza-4-ones" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Suzuki-Miyaura and Buchwald-Hartwig Reactions Utilizing a Set of Complimentary Imidazopyridine Phosphine Ligands" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:20 am 
	
"Photoenzymatic Catalysis: Using Light to Reveal New Enzyme Functions" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 12:00 pm 
	
"Enantioselective Dearomatization of Heterocyclic Cations" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Design and Synthesis of Biologically Active Heterocycles 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Selective Synthesis and Functionalization of Heterocycles for CFTR, Immunology, and Virology Targets" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Hypervalent Iodane Mediated Halogenations: Versatile Tools for the Exploration of Novel Reactivities and Structural Motifs" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Amine Diazotisation as a New Heterocycle Alkylation Process" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Paradigm Shifting Synthesis Technologies 
 
 
 
						
9:00 am - 9:30 am 
	
"Applications of New Synthetic Methods for the Total Synthesis of Cyclic Guanidine Natural Products" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"The Use of Flow Technology for the Synthesis of Heterocycles and Pharmaceuticals" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:20 am 
	
"Nickel-Catalyzed Synthesis and Functionalization of Nitrile-Containing Building Blocks" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 12:00 pm 
	
"From Molecules to Molecular Surfaces: Exploiting the Synergy Between Synthesis and Electrochemistry" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Catalytic Methods for Heterocyclic Compound Preparation and Functionalization 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Chemistry Innovation and Biological Discovery through Natural Product Total Synthesis" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Regiodivergent and Enantioselective Alkene Difunctionalizations for N-Heterocycles Syntheses" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Unified Synthesis of the Asnovolins and Related Spiromeroterpenoids" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
New Reaction Strategies for Heterocyclic Compound Design 
 
 
 
						
9:00 am - 9:15 am 
	
"A Deoxyfluoroalkylation Strategy for Accessing Highly-Substituted Aryl and Heteroaryl Trifluoromethanes" 
 
 
 
						
9:15 am - 9:20 am 
	
Discussion
 
 
						
9:20 am - 9:35 am 
	
"Direct and Selective Amination Methods for the Synthesis of Nitrogen Heterocycle-Containing Compounds" 
 
 
 
						
9:35 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"P450 Catalyzed Transformations" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:20 am 
	
"Investigating C-H Activation Chemistry of N-Phenyl Azoles: Discovery of a New Class of Herbicides" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 12:00 pm 
	
"Development of a Process to CC-90010: Lessons in Ortho-Bromination, Selective Solubility, and Pd Deactivation" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:00 pm - 7:30 pm 
	
Business Meeting 
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair 
 
 
						
7:30 pm - 9:30 pm 
	
Total Synthesis of Heterocyclic Natural Products 
Session in memory of Victor Snieckus and Tom Beattie. 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Making Chiral Heterocycles Using Chiral Heterocycles" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Heterocyclic Enzyme Inhibitors Targeting Drug Resistant Pathogens" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Strategies and Tactics for the Rapid Synthesis of Molecular Complexity" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Route Optimization of Heterocyclic Compounds of Pharmaceutical Relevance 
 
 
 
						
9:00 am - 9:30 am 
	
"Lorlatinib: From Enabling Synthesis to Commercial Route" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Process Innovation to Enable the Scalable Manufacture of Sotorasib" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:20 am 
	
"Substitution or Synthesis? Approaches to N-(Hetero)Aryl Piperidines" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 11:45 am 
	
"Synthetic Design of Pyrrolyl Natural Products" 
 
 
 
						
11:45 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:05 pm 
	
"Mechanistic Investigations into the Formation of Sulfur-Containing Heterocycles by C–H Bond Functionalization" 
 
 
 
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Keynote Session: Construction of Complex Molecular Architectures 
 
 
 
						
7:30 pm - 8:10 pm 
	
"Designing Long Acting Injectable Prodrugs of Naltrexone: Sometimes Brick Dust is a Good Thing" 
 
 
 
						
8:10 pm - 8:20 pm 
	
Discussion
 
 
						
8:20 pm - 9:10 pm 
	
"Total Synthesis of Indole Alkaloids" 
 
 
 
						
9:10 pm - 9:20 pm 
	
Discussion
 
 
						
9:20 pm - 9:30 pm 
	
Closing Remarks
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure