Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
7:40 pm - 9:30 pm 
	
Creative Approaches to Heterocyclic Targets 
 
 
 
						
7:40 pm - 7:45 pm 
	
Opening Remarks
 
 
						
7:45 pm - 8:15 pm 
	
"Identification of Molecular Glues by DNA-Encoded Library Technology" 
 
 
 
						
8:15 pm - 8:25 pm 
	
Discussion
 
 
						
8:25 pm - 8:40 pm 
	
"Microwave-Promoted Iminyl Radical Cyclizations: Application to the Total Synthesis of Virosinine A" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Adventures in the Development of Complex Pharmaceuticals" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Heterocycles to Probe Biological Activity 
 
 
 
						
9:00 am - 9:30 am 
	
"Access and Synthesis of Heterocycle Moieties for Efficient Medicinal Chemistry SAR Studies" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Development and Multi-Kilogram Manufacture of Iberdomide (CC-220)" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:20 am 
	
"Taming the Unnatural – Advances in Non-canonical Amino Acid Synthesis for Drug Discovery and Beyond" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 12:00 pm 
	
"Development of a Commercial Manufacturing Process for Sotorasib (AMG 510), a First-in-Class KRASG12C  Inhibitor" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Advances in Catalytic Methods and Mechanisms 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Asymmetric Catalysis with Peptides" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"The Metal Matters: Multi-Metallic Catalysts to Access New Applications of Hydrogen Borrowing Amination" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Selective Functionalization of Pyridines, Diazines and Pharmaceuticals via Unconventional Intermediates" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Group Photo
 
 
						
9:00 am - 12:30 pm 
	
Exploring Heterocyclic Chemistry 
 
 
 
						
9:00 am - 9:30 am 
	
"Collaborative Medicinal Chemistry in Infectious Disease and Neuroscience" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Synthesis of Heterocycles Through Aryne Intermediates" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:45 am 
	
Coffee Break
 
 
						
10:45 am - 11:00 am 
	
"Chemistry Problem Solving through Continuous Reactor Design" 
 
 
 
						
11:00 am - 11:10 am 
	
Discussion
 
 
						
11:10 am - 11:40 am 
	
"Deaminative Cross-Couplings" 
 
 
 
						
11:40 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:20 pm 
	
"Single Atom Logic for Skeletal Editing" 
 
 
 
						
12:20 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Heterocyclic Natural Products 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Heterocycle Inspired Anionic Cascade Adventures" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Blue Plastic: Seaweed-Derived Biomass to Replace Single-Use Plastics" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"The 'Endless Sea'. Discovery of Unexpected New Molecules from the Sand Beneath Your Feet" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 12:30 pm 
	
Novel Strategies of Construction with Heterocycles 
 
 
 
						
9:00 am - 9:30 am 
	
"Heterocycle Preparation Using aza-Heck Reactions" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Incorporation of Orphaned Cyclopropanes in Heterocyclic Molecules" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:50 am 
	
Coffee Break
 
 
						
10:50 am - 11:20 am 
	
"New Transformations for the Synthesis of Azetidines and Oxetanes" 
 
 
 
						
11:20 am - 11:30 am 
	
Discussion
 
 
						
11:30 am - 12:00 pm 
	
"Anaerobic Oxygen Atom Transfer Reactions Promoted by Photoexcited Nitroarenes" 
 
 
 
						
12:00 pm - 12:10 pm 
	
Discussion
 
 
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Harnessing Heterocyclic Compounds as Therapeutics 
 
 
 
						
7:30 pm - 8:00 pm 
	
"Discovery of a Novel Quinoline-Based Proteasome Inhibitor for Human African Trypanosomiasis (HAT)" 
 
 
 
						
8:00 pm - 8:10 pm 
	
Discussion
 
 
						
8:10 pm - 8:40 pm 
	
"Disrupting How We Make Molecules: Molecular Editing and 3D Rich Architectures" 
 
 
 
						
8:40 pm - 8:50 pm 
	
Discussion
 
 
						
8:50 pm - 9:20 pm 
	
"Discovery of CFTR Modulators for The Treatment of Cystic Fibrosis" 
 
 
 
						
9:20 pm - 9:30 pm 
	
Discussion
 
 
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s) 
 
 
						
9:00 am - 12:30 pm 
	
Transforming Heterocycles 
 
 
 
						
9:00 am - 9:30 am 
	
"Adventures in Early Process Development from the Lilly Portfolio" 
 
 
 
						
9:30 am - 9:40 am 
	
Discussion
 
 
						
9:40 am - 10:10 am 
	
"Accessing Fluoroalkyl Heterocycles by Deoxyfluoroalkylation and Reactions of Fluorinated Alkenes" 
 
 
 
						
10:10 am - 10:20 am 
	
Discussion
 
 
						
10:20 am - 10:45 am 
	
Coffee Break
 
 
						
10:45 am - 11:00 am 
	
"Evolution of ABBV-105 Synthetic Route and Process Development to Phase 2" 
 
 
 
						
11:00 am - 11:10 am 
	
Discussion
 
 
						
11:10 am - 11:40 am 
	
"Rapid Evolution of the Manufacturing Process for KRAS Inhibitor GDC-6036" 
 
 
 
						
11:40 am - 11:50 am 
	
Discussion
 
 
						
11:50 am - 12:20 pm 
	
"Synthesis of Medicinally Relevant Isoquinolones and Derivatives Thereof via Rh-Catalyzed C-H Activation" 
 
 
 
						
12:20 pm - 12:30 pm 
	
Discussion
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						
7:30 pm - 9:30 pm 
	
Keynote Session: Innovations Fueled by Heterocycles 
 
 
 
						
7:30 pm - 7:45 pm 
	
"Improvement on the Synthesis and Thermostability of Imidates Showcased from Drug Discovery to Materials Science" 
 
 
 
						
7:45 pm - 7:55 pm 
	
Discussion
 
 
						
7:55 pm - 8:30 pm 
	
"Selective Interconversion of Carbohydrate Isomers" 
 
 
 
						
8:30 pm - 8:40 pm 
	
Discussion
 
 
						
8:40 pm - 9:15 pm 
	
"Synthesis and Application of Heterocycles in Selectivity-Driven Chemistry" 
 
 
 
						
9:15 pm - 9:25 pm 
	
Discussion
 
 
						
9:25 pm - 9:30 pm 
	
Closing Remarks
 
 
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am 
	
Departure