Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Methodology and Heterocyclic Synthesis
7:40 pm - 8:10 pm
"Development of Chemical Reactions to Advance Drug Discovery"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Bisindolylmethanes: From Synthesis to Luminescence Scaffold"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Transforming Molecules into Medicines: Innovative Case Studies in Process Development at Amgen"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Synthesis of Heterocyclic Compounds
9:00 am - 9:30 am
"Empowering Manufacturing Process for Active Pharmaceutical Ingredients: Application of Enabling Technologies"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Lateral Lithiation for Heterocycle Synthesis: Scope and New Reaction Discovery"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Phase-Appropriate and Scalable Synthesis of a KRAS Inhibitor"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Synthetic Contributions Toward the Discovery and Development of Atirmociclib"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Catalysis and Heterocyclic Synthesis
7:30 pm - 8:00 pm
"Recent Advances in Cross-Electrophile Coupling: New Strategies, Substrates, and Reductants"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Expanding the Dimensions of Quinolines using Informed High-Throughput Experimentation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Asymmetric Catalysis with Cluttered Transition States and Flexible Catalysts"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Transformative Power of Heterocycles
9:00 am - 9:30 am
"Development of a Photoredox Catalyzed Reductive Desulfonylation For The Synthesis of LY3556050"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Redox Catalysis with Sulfur and Nitrogen Heterocycles"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Weak Bonds, Strain, Rearrangement, and Nitrogen Transfer: Reactivity Design with Functionalized Hydroxylamines"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"New Developments in Multicomponent Asymmetric Fe-Catalyzed Radical Cross-Coupling Reactions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Heterocycles as Inspiration for Synthesis
7:30 pm - 8:05 pm
"Diversity-Oriented Reconstructive Synthesis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Data Science Enabling Synthesis and Unveiling Bias"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Complex Alkaloid Total Synthesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Expanding the Frontiers in Heterocycles
9:00 am - 9:30 am
"Into the Next Dimension: Pharmaceutically Relevant High-Dimensional Scaffolds"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Biosynthesis of Natural and New-to-Nature Glycosides in Engineered Yeast"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Development, Characterization, and Control of Antibody-Oligonucleotides Conjugate Manufacturing Processes"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Phosphorescent OLED Technology: Materials, Device Architectures, and Manufacturing"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Complex Heterocycle Discovery and Assembly
7:30 pm - 8:00 pm
"Novel Synthetic Approaches to Complex API Assembly"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Innovative Strategies Toward Complex API Synthesis"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Teaching Old Drugs New Tricks"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Methodology and Heterocycle Synthesis
9:00 am - 9:30 am
"Pyrrole Rearrangements for New Compound Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"(4+3) Cycloadditions with Epoxy Enolsilanes as Dienophiles"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Synthesis of 2-Aminopyrimidines by C2-Selective Pd-Catalyzed Amination of 2,4-Dichloropyrimidine"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Advancing Crop Protection via Underrepresented Heterocyclic Scaffolds"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Heterocycles Inspiring Creativity in Organic Synthesis
7:30 pm - 8:00 pm
"[2+2]-Cycloadditions to In Situ Analytical Data-Driven Electrochemical Optimization"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Empowering Organic Synthesis: From Unique Methods to Complex Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Site-Selective C—H Oxidation in Heterocycles"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure