Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Impact of Chemical Biology in Drug Discovery
7:40 pm - 8:25 pm
"Activity-Based Proteomics: Protein and Ligand Discovery on a Global Scale"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Small-Molecule Control of Transcription"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Matter Diversity for Probes and Therapeutics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"New Synthetic and Biophysical Methodologies in Fragment-Based Cancer Drug Discovery"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Expanding DNA-Encoded Library Chemical and Target Space with Novel Chemistries"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Chemical Tools to Understand Mechanisms that Control the Physiological Distribution of Therapeutics"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"DNA Recognition and Sensing with Designed Metal Complexes"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"Photo-Affinity Probes to Interrogate Protein-Protein and Protein-Drug Interactions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Chemistries and Reaction Scouting
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Synergistic Cooperation Between Mechanistic Investigation and Catalysis: Towards Rational Design"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Recent Advances in Frustrated Acid/Base Complexes as Potential Cooperative Catalysts for Practical Synthetic Transformations"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Discovery of Novel, Small-Molecule Autophagy Inhibitors Through Phenotypic and Target-Based Approaches"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Modulation of NRF2 in Chemoprevention and Cancer Therapy"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Chemical Probes with a Unique Bioorthogonal Cleavage Site for Improved Metabolomic Analysis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Probes and Cellular Assays for Upcoming Druggable Targets
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Emerging Chemical Labeling Methods to Analyze and Control RNA"
9:40 am - 9:45 am
Discussion
9:45 am - 10:15 am
"CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide to Quantitate Expression Dynamics"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
"Mapping of Immunomodulatory Receptor Protein Interactions via Photocatalytic-Based Proximity Labeling of the Cell Surface"
11:20 am - 11:25 am
Discussion
11:25 am - 11:55 am
"Chemical Probes to Study Epigenetic Regulation by Histone Demethylases in Health and Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Bioinformatics-Guided Phenotypic Screen Discovers an AKR Prodrug to Target Oncogenic Transcription Factor Driven Lung Cancers"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Photoswitchable Chimeras Enable Optical Control of Targeted Protein Degradation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
High Throughput Experimentation in Chemistry and Chemical Biology
7:30 pm - 8:00 pm
"Enabling and Accelerating Drug Discovery with High Throughput Technologies"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
"Zebrafish Behavioral Profiling for Neuroactive Drug Discovery"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Functional Signature Ontology (FUSION) Mapping for Rapid Mechanism of Action Discovery"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Activity-Based DNA-Encoded Library Screening"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Discovery of Small Molecule Inhibitors of SIRPa-CD47 Interaction"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Methods and Machine Learning in Target Identification and Structure-Activity Relationships
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Ultra-Large Library Docking for Novel Ligand Discovery"
9:35 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Applications of Artificial Intelligence-Driven Molecular Design in Drug Discovery Projects"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:15 am
"Informatics-Enabled Early Drug Discovery: From Screening Collection Design to Omics Data Integration"
11:15 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Lessons from the Largest Prospective Study of Machine Learning for Hit Discovery"
11:50 am - 11:55 am
Discussion
11:55 am - 12:25 pm
"The Use of Machine Learning for Target and Drug Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Omics-Enabled Chemical Biology and Drug Discovery
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Multiplexed Parallelization of Binding Site Hotspot Mapping"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Small-Molecule Inhibitors, Degraders and Activators of CRISPR-Associated Nucleases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Novel and Optimized Chemoproteomic Methods for Identifying and Mapping Small Molecule-Protein Interactomes"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring Protein Homeostasis to Expand the Druggable Proteome
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:40 am
"Structure-Based PROTAC Design"
9:40 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Proteomic Connectivity Maps for Characterization and Targeting of Drugs"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"High-Throughput Chemical Proteomics for Chemical Biology"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Drugging the Core Particle of the Proteasome to Increase Protein Degradation Rates"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Targeted Degradation of Aberrant Tau in Frontotemporal Dementia Patient-Derived Neuronal Cell Models"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: New Mechanisms of Action in Therapeutics
7:30 pm - 8:15 pm
"Chemical Tools for Unraveling Parasite Biology"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:10 pm
"Insights in the Membrane-Bound Proteasome in Health and Disease"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure