Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Scaling Chemical and Biological Data for AI-Driven Drug Discovery
7:40 pm - 8:25 pm
"DEL Data and ML Binding Models: Factors Impacting Predictive Accuracy"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Chemical Approaches to Regenerative Organ Repair"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Allosteric Drug Discovery in the Age of Machine Learning"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Mechanisms of Induced Proximity
9:00 am - 9:25 am
"Interrogating the Druggable Proteome with Proximity Pharmacology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"New Approaches to Target Undruggable Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"MrTAC: Harnessing the Lysosome for Targeted Degradation of the Intracellular Proteome"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Fluorine-Displacement Probes to Interrogate Post-Translational Modification Related Protein-Protein Interactions"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Expanding what is Druggable Today
7:30 pm - 7:50 pm
"Exploring PRMT Selectivity: Mapping Active Site Landscapes for Selective Drug Discovery"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Structure-Based Design of Small Molecule Inhibitors of Protein Arginine Methyltransferase 5 (PRMT5)"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"SPEAR-GN: A Data-Driven Machine Learning Approach to Enable Rational Design of Gram-Negative Permeant Molecules"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Decoding Transcription Coactivators: Mechanisms & Molecules"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Encoding and Predicting Therapeutic Function of Oligonucleotides
9:00 am - 9:25 am
"Engineering Polymerases for Applications in Synthetic Biology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Characterization and Inhibition of lncRNA-Protein Interactions by Chemical Probing Assays and NMR Spectroscopy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Group Photo / Coffee Break
10:40 am - 10:55 am
Short Talk Selected from Poster Abstracts
10:55 am - 11:00 am
Discussion
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Delivering the Promise of RNAi to Extra-Hepatic Tissues"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Chemically Formulating Functional Nucleic Acids to Overcome Biological Barriers to Enhance Their Cytosolic Delivery and Therapeutic Effects"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Encoded Synthesis in Drug Discovery
7:30 pm - 7:50 pm
"Beyond Binding: Phenotypic and Functional Screening of Encoded Libraries"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Using Surfactant-DNA Complexes to Access New DEL Chemical Space"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Using DEL for Targeted Protein Degradation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Phenotypic DEL in Droplets for TPD and Beyond"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Enhancing the Chemistry-Biology Interface: Automation and OMICs Analytics
9:00 am - 9:20 am
"Understanding and Predicting the Membrane Permeability of Cyclic Peptides Based on Large-Scale Data"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Chemical Synthesis and Direct-to-Biology Cellular Evaluation for the Discovery of a Lead GPCR Agonist"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Leveraging Automation in a High-Throughput Experimentation Platform to Fuel ML-Driven Drug Discovery"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Matrix Completion of Palladium, Nickel, and Copper Catalyzed C–N Cross Couplings"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Development and Implementation of ML Tools to Impact Medicinal Chemistry Campaigns"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Innovative Automated Workflows: Parallel Semi-Purification & ChemVault"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Generating Insights: AI / ML at the Chemistry-Biology Interface
7:30 pm - 7:50 pm
"Automated High-throughput Chemistry to Enable Predictive Synthesis/AI in Drug Discovery"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Improving Efficiency and Design Spaces of Drug Discovery Projects via Predictive Synthesis Analytics/AI"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Leveraging ML for Drug Discovery and Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"NeuralPLexer3: Accurate Biomolecular Complex Structure Prediction with Flow Models"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
High Throughput Phenotypic Screening and Deconvolution
9:00 am - 9:25 am
"In Vivo Neuroactive Small Molecule Discovery Using Larval Zebrafish"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Quantitative High-Throughput Screening of Human Neurodevelopment Using RosetteArray® Technology"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Short Talk Selected from Poster Abstracts
11:15 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Expanding Molecular Diversity with pDOS Strategy to Modulate Protein-Protein Interactions"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Finding Disease Phenotypes and Candidate Therapeutics Using Images: Cell Painting"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Perspectives and Applications of Generative AI
7:30 pm - 7:50 pm
"Accelerating the Synthesis of Small Molecule Drugs Through Automation and AI-Driven Chemistry"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Leveraging AI and Generative Modeling to Accelerate Hit Finding in Early Drug Discovery"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Generative AI in Drug Discovery: Revolution, Evolution, or Complete Nonsense"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure