Regulation of Genome Function by Histone and Nucleic Acid Modifications in Health, Development and Disease

Histone, DNA, and RNA modifications are central players in the regulation of genome function. Modifications such as methylation, acylations, phosphorylation, and other modification types play major roles in the transmission of epigenetic information. They dictate chromatin structure and function and are relevant to physiology and pathology. Recent seminal discoveries have greatly expanded our understanding of the importance of histone, DNA, and RNA modifications; however, many essential questions remain unanswered. At our 2025 GRC, we will discuss key concepts and mechanisms focusing on diverse systems, approaches, and experimental innovations. This meeting will bring together scientists from multiple disciplines, including molecular biology, biochemistry, epigenetics, chemical and structural biology, and chemistry, addressing both basic and translational concepts and presenting new advances. We look forward to an exciting exchange of viewpoints, stimulating discussions of novel ideas and discoveries, and forging new collaborations.