Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span
7:40 pm - 7:45 pm
General Discussion
7:45 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Systemic IGFs and The Skeleton: Revisiting and Old Story"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Effects of Nutritional Interventions on the IGF and Insulin Axis and Health Span"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
IGF and Insulin Actions in Systemic and Tissue Inflammation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Insulin and IGF-1 Effects on T Cells"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Insulin-Like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Pulmonary Neuroendocrine Stem Cells are Controlled by an Autocrine IGF-IGFBP Complex Activated by Airway Injury"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:05 am
"Changes in the Microbiota of Mice with Allergic Asthma are Partially Reversed by IGF1R Blockade"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Using Viruses to Study the Functions of IGF1 and IGF1R"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Nucleic Acid Immunity and Metabolic Homeostasis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Intraperitoneal, but not Intracerebroventricular, IGF1 Treatment Repairs Ischemic Stroke-Induced Acute Gut Damage and Improves Cognitive Behaviors in Acyclic Middle-Aged Female Rats"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin Actions in the Central Nervous System in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"IGF-I Plays a Complex Role in Amyotrophic Lateral Sclerosis"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"IGF-2 as a Novel Therapeutic Candidate for Ischemic Stroke: Unveiling Its Neurogenic and Angiogenic Potential"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Cyclic Glycine Proline Regulates IGF-1 Function and its Clinical Implications in Small Vessel Diseases"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"IGF1 at the Intersection of Neurodevelopment and Cancer"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Investigating the Relationship Between IGF Signaling and Amyloid Precursor Protein (APP) Processing in Prostate Cancer"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms Regulating the IGF and Insulin Signaling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"One Receptor, Many Hormones: Any Lessons from Drosophila Insulin Receptor"
9:30 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Defining Autoregulatory Roles for the IGF-1 and Insulin Receptor C-Termini in Kinase Activation"
9:50 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Analogues of Insulin, IGF1, and IGF2 for Studying the Biological Functions of Hormones and Their Receptors"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Inter-Molecular Activation Between Insulin Receptors by a Dimeric Aptamer Agonist"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Beyond Insulin: Insulin Receptor Activators"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Structural and Functional Insights into IGF2R-Ligand Interactions: Engineering and Analysis of Extracellular Domain Constructs"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Ligands as Determinants of Specificity in Insulin Receptor-Mediated Phenotypic Regulation in C. Elegans "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Exposome Impact on the IGF and Insulin Axis
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"IGF-1 Signaling: A Molecular Cascade Neglected by Endocrine Disruption Science"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:25 pm
"Environmental Stressors Across the Lifespan: The Impact on CNS Insulin/IGF-1 Signaling"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Laboratory Animal Diets: Critical Variables that Affect In Vivo Research and Metabolic Disease Development"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 8:55 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Session in Memory of Dr. Valentine Macaulay : IGF and Insulin as Targets for Cancer Prevention
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Effects of Lifestyle Intervention (Mediterranean Diet and Exercise) on the IGF System and Tumorigenic Potential in Breast Cancer Survivors"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"LX-101: A Novel Approach to Targeting IGF-1R in Cancer"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Short-Term IGF Blockade Remodels Prostate Cancer Tumor Microenvironment"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Viral Insulin/IGF-Like Peptides as Novel IGF1R Inhibitors for Triple-Negative Breast Cancer"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"IGF1R Targeted NK Cell Engager Kills Proliferating and Quiescent Hormone Receptor Positive Breast Cancers"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"More than Target Practice: Resurrecting an Orphan Drug for Two Orphan Diseases"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"IGFBP-6 Regulates Progesterone Response in T47D Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Insights on the IGF and Insulin Axis Gained from Human Mutations
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Human IGF1R Insufficiency: Insights into Human Growth and Development Using Pluripotent Stem Cell Models"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"IGF Deficiency: Spectrum of Molecular Defects and Clinical Features"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Unraveling the Role of IGF2 in Silver-Russell and Temple Syndromes: The Need for Accurate Research Models"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Identification and Characterization of Functional Coding Variants in Human Longevity Pathway"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Impact of IGF and Insulin on Development and Tissue Remodeling
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"The Role of Vascular Smooth Muscle Cell IGF1R in Age-Related Cerebrovascular Dysfunction"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"JUV-161: The Basis of an Investigational New Drug"
10:00 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Unravelling the Paracrine Role of Endothelial IGF-1 Receptor in Mediating Favorable Gut and Adipose Tissue Remodeling in the Setting of Diet-Induced Insulin Resistance and Obesity"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Insulin, Gut Neuropeptides, and Juvenile Hormone in Drosophila Aging"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"In Vitro Models of Insulin Resistance in Adipose and Muscle Indicate Differences in Glucose Uptake Response Between IGF-II and Vesiculin"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Novel MicroRNAs Associated with Hypoxia in Fetal Hepatocytes: Potential Mechanisms Regulating Intrauterine Growth Restriction"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Dissecting the Role of IGF1 from GH in the Regulation of Liver Health and Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
IGF and Insulin in Cancer
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"IRS2 Interacts with PLK1 to Regulate Mitotic Progression"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"IGF and Insulin System in Regulating Hallmarks of Cancer"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"IGFBPs Mediate Antiestrogen Activity in Breast Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
"The Effect of Hyperinsulinemia and Insulin Receptor Isoforms in Triple-Negative Breast Cancer"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"The IGF-1R in Tumor Cell Adhesion and Metastasis: From Mice to Women"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure