Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Immunoengineering in Basic Biology and Clinical Translation
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"Vaccine Design to Elicit Broadly Protective Immune Responses against Potential Animal Spillover Viruses"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Engineering Hematopoietic Stem Cells"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immune Cell and Protein Engineering
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Anchored Cytokine Immunotherapy: Of Mice and Dogs and Men"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Engineering a Potent T Cell Response against Melanoma"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:30 am
"Targeting Glycans for Immunotherapy"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Early Bystander Effect of Vaccine Boosting of CAR T Cells Reinvigorates Endogenous Anti-Tumor T Cell Immunity To Regress Pancreatic Cancer"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"In Vivo Engineering of Disease-Specific T Cells for CAR T Cell Therapy and Autoimmune Disease Prevention"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Engineered Nanobodies to Visualize and Direct Antigen-Specific Tolerance"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"On and Off-Target of Immunoengineering Nucleic Acids"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"BLITz Forward to Lipid-Based Subunit Vaccines"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Nanoparticle Vaccines and Encoded Antibody Therapies"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Engineered Microorganisms
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Engineering Smart Probiotics with Disease Specific Function"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Reprogramming Immunity: The Promise of VNPs in Autoimmune Therapy"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Nature by Synthesis: Metal–Organic Framework Vaccines and Living VLP Packages for Innate Re-engagement"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Targeted Adjuvants to Reprogram Viral Particles into Immunogens"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Elucidating Early Immune Dynamics: GC Responses and Injection Site Niches in Long-Acting Vaccines"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Unlock the Adaptive Immune Repertoire with Polymeric Nanoparticle Adjuvant for the Next-Generation Vaccine Development"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunoengineering for Pharmaceutical Applications
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Sensing DNA as a Danger Signal Through the cGAS-STING Pathway"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"EpCAM Signaling Promotes Immune Suppression and Its Blockade Restores Anti-Tumor Immunity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Anti-Inflammatory Nanoparticles, Updates from the Clinic"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Human Immunology and Clinical Translation
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"From Precise Microbiome Genomics to Precision Medicine"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"Metabolic Control of Anti-Tumor Immunity"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Improving T Cell Redirection In Myeloma"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Leveraging Neoantigen Hierarchies to Maximize Anti-Tumor Immunity Using Therapeutic mRNA Vaccines"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Physiologically Authentic Lymphoid Organoid (PALO) To Study Human Immunity in a Dish"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Photoactivatable Lipid Nanoparticles Enhance Endosomal Escape and Drive Tertiary Lymphoid Structure Formation to Potentiate the Cancer-Immunity Cycle"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Interventional Radiology in Immunoengineering
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Engineering "Detect-Report-Degrade" Functions in Immune & Tumor Cells"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Irreversible Electroporation: A Local Tumor Ablation Technology with Systemic Immune Effects"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"In Vivo Imaging of Immunoengineered Cells"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Tissue Engineered 3D models to Elucidate the Role of Immunomodulation in Tissue Regeneration or Disease Progression"
9:35 am - 9:50 am
Discussion
9:50 am - 10:20 am
"High-Throughput Vascularized Tumor Microenvironment for Immunoengineering"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Vaccination by Microneedle Patch"
11:30 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Helminth-Inspired Supramolecular Biomaterials To Treat Autoimmune Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Microribbon Scaffolds Modulate Neutrophils and Activate Regulatory T Cells to Enhance Wound-Induced Hair Follicle Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Biologic Mesh Implantation Following Tumor Resection: Characterizing Mesh-Tumor Interactions and Feasibility for Perioperative Immunotherapy Delivery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunoengineering: The Next Frontier
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"MAPing Immune Responses to Improve Regeneration and Transplant Outcomes"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Migration Tunes T Cell Fitness"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Plant Molecular Farming as a Platform for Next-Generation Immunotherapies in Space"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure