Expanding Proximity Driven Pharmacology and Drug Discovery

The Gordon Research Conference on Induced Proximity Modalities and Therapeutics will bring together scientists from academia and industry to explore the latest advancements in this rapidly evolving and growing field. Induced proximity - harnessing molecular interactions to drive emergent therapeutic effects - has already led to breakthroughs such as molecular glues and PROTACs for targeted protein degradation which have progressed to the clinic for oncology indications and beyond. More recently, the concept has significantly expanded to include protein stabilization, sequestration, relocalization, and modulation of transcriptional and post-translational processes. These additional pharmacological outcomes open a new wealth of possibilities for therapeutic innovation and drug discovery. This conference will provide a platform for scientific discussions on technological and conceptual advances in discovering, characterizing and rationally designing proximity-based therapeutics. Sessions will, for instance, cover how chemical biology drives discovery, our evolving understanding of the structural basis of proximity-inducing agents, and the increasing impact of protein-based therapeutics. In addition to providing insights into the leading edge of discovery sciences, this meeting will also address challenges and opportunities in translating induced proximity agents to the clinic. While targeted protein degradation is an early and central pillar of induced proximity, a strong emphasis will be placed also on other proximity-inducing modalities. With a distinctive lineup of experts, the conference will foster an interactive environment that encourages collaboration and engagement, particularly for early-career scientists. As induced proximity-based therapies continue to expand, this meeting will serve as a timely and rigorous forum to shape the future of the field and accelerate innovation.