Sunday |
2:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Challenges in Infections
of the Nervous System |
| Discussion Leader: Xavier de Lamballerie (Aix Marseille University, France) |
7:40 pm - 8:00 pm | Xavier de Lamballerie (Aix Marseille University, France) "Results from a South-East Asia Survey of Central Nervous System Infections" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Christina Marra (University of Washington School of Medicine, USA) "Syphillis - New Challenges from an Ancient Foe" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Alexandre Alcais (INSERM, France) "Human Genetics of Neuroinfections" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pathogen Discovery in Infections of the Nervous System |
| Discussion Leader: Linfa Wang (Duke-NUS Graduate Medical School, Singapore) |
9:00 am - 9:25 am | Linfa Wang (Duke-NUS Graduate Medical School, Singapore) "The Role of Pathogen Discovery in Fighting CNS Infection" |
9:25 am - 9:30 am | Discussion |
9:30 am - 10:00 am | Michael Katze (University of Washington, USA) "System Biology Approaches to Study Host-Pathogen Interactions" |
10:00 am - 10:05 am | Discussion |
10:05 am - 10:25 am | Selected from Poster Abstracts: Yoann Crabol (Institut Pasteur du Cambodge, Cambodia) "Encephalitis in the Mekong Region" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:05 am | Group Photo / Coffee Break |
11:05 am - 11:15 am | Selected from Poster Abstracts: Thinesshwary Yogarajah (University of Malaya, Malaysia) "Coxsackievirus A16 and Enterovirus 71 Infection of SK-N-SH Cells Show Divergent Growth Characteristics Suggesting Differences in Viral Neuronotropism" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Selected from Poster Abstracts: Teck Hui Teo (Singapore Immunology Network, Singapore) "Co-Infection with Chikungunya Virus Alters Pathogenic Host Response and Prevents Experimental Cerebral Malaria" |
11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Selected from Poster Abstracts: Chitra Pattabiraman (National Centre for Biological Sciences, India) "Pathogen Discovery in Acute Encephalitis: Probing Beyond the JE Virus" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Selected from Poster Abstracts: Wude Mihret Woldemedhin (Armauer Hansen Research Institute (AHRI/ALERT), Ethiopia) "Chronic Meningitis in Immunocompromised Adult
Ethiopians" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Ursula Rohlwink (University of Cape Town, South Africa) "Biomarkers of
Neurological Injury and Inflammation in Paediatric Tuberculosis Meningitis" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ways of Invading the Nervous System |
| Discussion Leader: Lynn Enquist (Princeton University, USA) |
7:30 pm - 7:50 pm | Lynn Enquist (Princeton University, USA) "In Vivo Imaging of Herpersvirus Infection" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:20 pm | Matteo Caleo (CNR Neuroscience Institute, Italy) "From the Neuromuscular Junction to the CNS: Retrograde Trafficking of Botulinum Neurotoxins" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Ignacio Romero (The Open University, United Kingdom) "Role of MicroRNAs in Inflammation at the Blood-Brain Barrier" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Sara Salinas (Institut de Genetique Moleculaire de Montpellier, France) "Intracellular Trafficking and Signalling of the Coxsackievirus and Adenovirus Receptor" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cellular Tropism of the Nervous System and Host-Pathogen Interactions |
| Discussion Leader: Guillaume Dumenil (INSERM, France) |
9:00 am - 9:25 am | Guillaume Dumenil (INSERM, France) "Vascular Colonization by Neisseria meningitidis" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Christian Engwerda (QIMR Berghofer Medical Research Institute, Australia) "The Influence of IL-10 on Disease Pathogenesis During Malaria" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Lai Guan Ng (Singapore Immunology Network (A*STAR), Singapore) "Imaging Immunity to Infection" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Hans Christian Klein (University Medical Centre Groningen, The Netherlands) "PET Imaging of Infection and Inflammation of the Central Nervous System" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Giampietro Schiavo (University College London, United Kingdom) "The Role of Axonal Retrograde Transport in the Entry
and Spreading of Tetanus Toxin in the Nervous System" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Selected from Poster Abstracts: Eran Perlson (Tel Aviv University, Israel) "Rabies Virus Hijacks and Accelerates the
p75NTR Retrograde Axonal Transport Machinery" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Immune Responses
of the CNS to Invasion by Pathogens |
| Discussion Leader: Hans-Gustaf Ljunggren (Karolinska Institutet, Sweden) |
7:30 pm - 7:50 pm | Hans-Gustaf Ljunggren (Karolinska Institutet, Sweden) "Importance of NK Cells in Hantaavirus Infections" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:20 pm | Sonja Best (National Institute of Allergy and Infectious Diseases, NIH, USA) "The Induction and Evasion of Host Interferon Responses by Encephalitic Flaviviruses" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Shen-Ying Zhang (Rockefeller University, USA) "Herpes Simplex Encephalitis and Central Nervous System Intrinsic TLR3 Immunity" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:05 pm | Selected from Poster Abstracts: Rachel Lai (The Francis Crick Institute, United Kingdom) "Tuberculosis meningitis Immune
Resconstitution Inflammatory Syndrome Is Mediated by Innate Immune Response" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Selected from Poster Abstracts: Gabriella Passoni (Pasteur Institute, France) "Alphavirus Infections
in the Zebrafish Central Nervous System: Live Imaging of Viral Entry and Host
Response" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Pathogenesis: Clinical Features |
| Discussion Leader: Tom Harrison (St George's, University of London, United Kingdom) |
9:00 am - 9:25 am | Tom Harrison (St George's, University of London, United Kingdom) "Protective Immune Responses in Cryptococcal Meningitis - Evidence from Clinical Studies" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Marc Lecuit (Institut Pasteur, France) "Clinical, Microbiological and Pathophysiological Insights on Neurolisteriosis" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Peter Kennedy (University of Glasgow, United Kingdom) "Neuropathogenesis of Human African Trypanosomiasis" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Rob Heyderman (University College London, United Kingdom) "HIV and Bacterial Meningitis" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Mong-How Ooi (Universiti Malaysia Sarawak (UNIMAS), Malaysia) "CNS Infections in Children – Lessons Learnt for EV71" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Selected from Poster Abstracts: Michael Griffiths (University of Liverpool, United Kingdom) "Minocycline
Protects Mitochondria in Human HSV Infection" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mechanisms of Pathogenesis: Cellular Features |
| Discussion Leader: Soren Paludan (University of Aarhus, Denmark) |
7:30 pm - 7:55 pm | Soren Paludan (University of Aarhus, Denmark) "Cellular Pathogenesis of HSV Infections" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Laurent Renia (Singapore Immunology Network, Singapore) "Activated Brain
Endothelial Cells Cross Present Malaria Antigens" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Daniel Paris (Mahidol Oxford Tropical Medicine Research Unit, United Kingdom) "Pathogenesis of Rickettsial and Scrub Typhus Infections" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Selected from Poster Abstracts: Annukka Jaatinen (University of Turku, Finland) "Cytokine Profiling of
the Cerebrospinal Fluid of Lyme Neuroborreliosis Patients" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Nai-Jen Hsu (University of Cape Town, South Africa) "TNF-Dependent
Regulation and Activation of Innate Immune Cells Are Essential for Host
Protection Against Cerebral Tuberculosis" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Experimental Models of Infections of the Nervous System |
| Discussion Leader: Susan Ross (University of Pennsylvania, USA) |
9:00 am - 9:25 am | Susan Ross (University of Pennsylvania, USA) "New World Arena Virus Infection of the Mouse, a Model of Virus Encephalitis and Virus Induced Demyelination" |
9:25 am - 9:30 am | Discussion |
9:30 am - 9:55 am | Alister Craig (Liverpool School of Tropical Medicine, United Kingdom) "Pathogenesis of Cerebral Malaria" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Shie-Liang Hsieh (Academic Sinica, Taiwan) "Control of Inflammasome Activation in JE Virus Induced Neuroinflammation" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Thomas Morrison (University of Colorado, USA) "New Insight into the Clearance and Persistence of Arthritogenic Alphaviruses" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Marie Yang (University of Liverpool, United Kingdom) "Pneumococcal Meningitis: Virulence Factors and Routes of Invasion" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Selected from Poster Abstracts: Beate Sodeik (Hannover Medical School, Germany) "Importin a7 Is Required for Efficient Nuclear Targeting of Incoming HSV1 Capsids" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:20 pm | Selected from Poster Abstracts: Jingshu Zhang (HKU-Pasteur Research Pole, Hong Kong SAR China) "Ancient Ubiquitous
Protein 1 (AUP1) Is Involved in the Egress of Type 1 Dengue Virus" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Ways to Control Infections of the Nervous System: From Field to Bench to Bed |
| Discussion Leader: Jane Cardosa (Sentinext Therapeutics, Malaysia) |
4:00 pm - 4:20 pm | Jane Cardosa (Sentinext Therapeutics, Malaysia) "From Pathogen Studies to Vaccine Development" |
4:20 pm - 4:25 pm | Discussion |
4:25 pm - 4:50 pm | Gregory Smith (Northwestern University, USA) "A Genetic Dissection of Herpesvirus Neural Targeting and Its Implications for Gene Delivery" |
4:50 pm - 4:55 pm | Discussion |
4:55 pm - 5:20 pm | Christopher Broder (Uniformed Services University of the Health Sciences, USA) "A Human Monoclonal Antibody Therapy for People and a ‘One Health’ Vaccine for Horses Against the Hendra Virus and Nipah Virus Threats" |
5:20 pm - 5:25 pm | Discussion |
5:25 pm - 5:50 pm | Mark Simmerman (Sanofi Pasteur, Thailand) "Novel JE and DENV
Vaccines" |
5:50 pm - 5:55 pm | Discussion |
5:55 pm - 6:00 pm | Closing Remarks |
6:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |