Saturday 
 
 
1:00 pm - 5:00 pm 
	
Arrival and Check-in
 
 
						
3:00 pm - 3:15 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						
3:15 pm - 4:00 pm 
	
Keynote Session: Sensing Through Disorder 
 
 
 
						
3:15 pm - 3:50 pm 
	
"Disordered Sensing: From Basic Principles to De Novo Sensor Design" 
 
 
 
						
3:50 pm - 4:00 pm 
	
Discussion
 
 
						
4:00 pm - 5:30 pm 
	
Poster Session 
 
 
						
5:30 pm - 7:30 pm 
	
Theory and Application of Disordered Sequences 
 
 
 
						
5:30 pm - 5:40 pm 
	
"Unexpected Energetics in the Transition State Ensemble for Folding and Binding of an Intrinsically Disordered Short Linear Motif to a Folded Domain" 
 
 
 
						
5:40 pm - 5:45 pm 
	
Discussion
 
 
						
5:45 pm - 5:55 pm 
	
"Towards Rational IDP Drug Design with Ensemble-Based Pharmacophore Analyses" 
 
 
 
						
5:55 pm - 6:00 pm 
	
Discussion
 
 
						
6:00 pm - 6:10 pm 
	
"The Impact of Multiple Attractions on Liquid-Liquid Phase Separation" 
 
 
 
						
6:10 pm - 6:15 pm 
	
Discussion
 
 
						
6:15 pm - 6:25 pm 
	
"DNA Binding Redistributes Activation Domain Ensemble and Accessibility in Pioneer Factor Sox2" 
 
 
 
						
6:25 pm - 6:30 pm 
	
Discussion
 
 
						
6:30 pm - 6:40 pm 
	
"X-Ray Footprinting as a Strategy to Identify Intra- and Intermolecular Contacts of Intrinsically Disordered Proteins at Single-Residue Resolution" 
 
 
 
						
6:40 pm - 6:45 pm 
	
Discussion
 
 
						
6:45 pm - 6:55 pm 
	
"Interdomain Interaction Through Structural Disorder in Nuclear Receptors" 
 
 
 
						
6:55 pm - 7:00 pm 
	
Discussion
 
 
						
7:00 pm - 7:10 pm 
	
"Characterization of pH-Induced Distinct Conformations of β2 -Microglobulin" 
 
 
 
						
7:10 pm - 7:15 pm 
	
Discussion
 
 
						
7:15 pm - 7:25 pm 
	
"The Role of Aromaticity in the N-Terminal Region of alpha-Synuclein from Molecular Simulations" 
 
 
 
						
7:25 pm - 7:30 pm 
	
Discussion
 
 
						
8:00 pm - 9:00 pm 
	
Dinner
 
 
						
	Sunday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						
9:00 am - 11:00 am 
	
Emergent Properties of IDRs: Assemblies and Systems 
 
 
 
						
9:00 am - 9:10 am 
	
"Liquid-Liquid Phase Separation of a Post-Translational Modifier SUMO1 Protein Driven by its Structured Part" 
 
 
 
						
9:10 am - 9:15 am 
	
Discussion
 
 
						
9:15 am - 9:25 am 
	
"Correlating the Ensembles of Transcriptional Activation Domains with Gene Expression Levels" 
 
 
 
						
9:25 am - 9:30 am 
	
Discussion
 
 
						
9:30 am - 9:40 am 
	
"Discovering Functionally Similar Disordered Proteins by Generic Sequence Features" 
 
 
 
						
9:40 am - 9:45 am 
	
Discussion
 
 
						
9:45 am - 9:55 am 
	
"Nuclear Speckle Proteins with RNA Recognition Motifs Form Intrinsic and RNA-Dependent Microphases" 
 
 
 
						
9:55 am - 10:00 am 
	
Discussion
 
 
						
10:00 am - 10:10 am 
	
"Development of Condensate Inducer to Treat Osteoarthritis" 
 
 
 
						
10:10 am - 10:15 am 
	
Discussion
 
 
						
10:15 am - 10:25 am 
	
"Connecting Molecular Dynamics and Tissue Mechanics Through the Material Properties of the Nucleoplasm" 
 
 
 
						
10:25 am - 10:30 am 
	
Discussion
 
 
						
10:30 am - 10:40 am 
	
"The Arabidopsis SOG1 Interactome Varies with its Phosphorylation-Dependent Transcriptional Activity" 
 
 
 
						
10:40 am - 10:45 am 
	
Discussion
 
 
						
10:45 am - 10:55 am 
	
"Cosolutes Tune the Structure and Function of Desiccation Tolerance IDPs" 
 
 
 
						
10:55 am - 11:00 am 
	
Discussion
 
 
						
11:00 am - 12:30 pm 
	
Poster Session 
Coffee will be served in the poster area from 11:00 am - 11:30 am 
 
 
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						
1:30 pm - 2:30 pm 
	
Mentorship Component: Navigating the Funding Landscape 
 
 
 
						
1:30 pm - 2:30 pm 
	
Panel Discussion 
Funding Insights in the Biophysical and Biological Sciences 
 
 
 
						
2:30 pm - 3:00 pm 
	
Evaluation Period 
Complete the GRS Evaluation Forms; Election of Future Chair(s) 
 
 
						
3:00 pm 
	
Seminar Concludes