Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Electron Beams and X-Rays
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Electron Videography of Nanodiscs"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Cryo-EM and Drug Discovery: Exploring New Opportunities"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Structure and Structure Ensemble Determination from Single-Molecule X-Ray Scattering Images: A Bayesian Approach"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Interference Scattering Approaches
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"DNA Origami Capture and Tethering of Intact Viruses and Label-Free Digital Detection by Photonic Crystal Enhanced Scattering Microscopy"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Label-Free Digital Immunoaffinity Assays"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
"Tracking Chromatin Motion in Live Cells: A Label-Free Approach with iSCORS"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Shedding Light on the Interactions and Dynamics of Biomolecules Freely Diffusing in Solution"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Label-Free Techniques to Probe the Assembly of BioCondensates"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Nanomechanical Approaches and Quantum
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Protein Optomechanics to Probe Vibration-Enabled Biological Function"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Quantum Sensing Enabled by Diamond Spin Qubits"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Enhancing Nanoscale Force-Detected Magnetic Resonance Detection Using Dynamic Nuclear Polarization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Interaction Control to Enhance Nanopore Sensing
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Nanopore Traps To Hold and Sense Single Proteins and Their Conformations"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Single-Molecule Profiling of Flaviviral NS2B/NS3 Protease Inhibition Using Engineered Nanopore Tweezers"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
"Biological Nanopores: An Emerging Tool for Single-Molecule Protein Dynamics and Sequencing"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"A Novel Approach for Multiplexed Biomarker Detection Using Single-Molecule Sensing"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Early-Stage Nucleosome Phase Separation Revealed by 3D Single-Molecule Structures"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Plasmonic and Evanescent Scattering Microscopy for Label-Free Imaging of Single Proteins"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Opportunities and Challenges in Single Molecule SERS"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Single Plasmonic Nanoparticles for Single-Molecule Biosensing"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Nanoaperture Optical Tweezers
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Monitoring Conformational Changes of Single Unlabeled Proteins"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Direct Observation of Single Intrinsically Disordered Protein Conformational Dynamics in Solution"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
"Metamaterial Plasmonic Tweezers: Enabling Stable Nanoscale Trapping and Advanced Sensing"
10:30 am - 10:35 am
Discussion
10:35 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Microsecond Molecular Dynamics Combined with Nanoaperture Optical Tweezers Uncover Mutation-Driven Modulation of PR65 Conformational Mechanics"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Inverse Design of Plasmonic Nanotweezers"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unlabeled Fluorescence and Mass Photometry
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Time-Unlimited Observation of Bimolecular Mechanisms With Confined Diffusion Mass Photometry"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Ultraviolet Autofluorescence Detection of Label-Free Proteins Enhanced by Nanophotonics"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Single Molecule Detection, Identification, and Functional Characterisation via Membrane Deformations"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Single-Molecule Detection and Hydrodynamic Profiling with Optical Microcavities: Capabilities, Limits, and Mysteries"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"A Single Molecule Technology for Decoding Protein Dynamics and Biophysics"
10:00 am - 10:05 am
Discussion
10:05 am - 10:40 am
Coffee Break
10:40 am - 11:05 am
"Full Wave Numerical Modelling of Cavity Surface Roughness"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"High Quality Factor Resonators For Sequencing the Genome, Proteome, and the Glycome"
11:35 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Leveraging Whispering-Gallery-Mode Optical Resonators for Biomedical Applications: Ultrasensitive and Label-Free Detection of Nanoparticles and Cells"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Solid-State Based Nanopore Sensing
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Label-Free Detection with Nanopores: Advancing Single-Molecule Science"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Sizing Proteins with Nanopores"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Dual Optical-Electrical Nanopore Sensor to Enable Quality Control in Biomanufacturing"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure