Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | G Protein Coupled Receptors |
| Discussion Leader: Gebhard Schertler (Paul Scherrer Institute / ETH Zürich, Switzerland) |
7:40 pm - 8:00 pm | Klaus-Peter Hofmann (Charite Institute for Medical Physics and Biophysics, Germany) "Versatility and Precision of GPCR Interactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Andreas Pluckthun (University of Zurich, Switzerland) "Evolving Stable Receptors: Principles, Structural Studies and Use in Drug Discovery" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Chris Tate (Medical Research Council, United Kingdom) "Crystal Structure of the Human Adenosine A2a Receptor Bound to an Engineered G Protein" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ehud Isacoff (University of California, Berkeley, USA) "An Optical View of mGluR Gating Mechanism" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Physiology of Transporters and Channels |
| Discussion Leader: Edmund Kunji (MRC - Mitochondrial Biology Unit, United Kingdom) |
9:00 am - 9:20 am | Geoffrey Abbott (University of California, Irvine, USA) "Potassium Channel-Solute Transporter Co-Regulation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Stephan Pless (University of Copenhagen, Denmark) "Atomic Basis for Therapeutic Activation of Neuronal Potassium Channels" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Frances Ashcroft (University of Oxford, United Kingdom) "KATP Channels and Neonatal Diabetes: When Ligand Recognition Goes Wrong" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Nancy Carrasco (Yale School of Medicine, USA) "The Sodium/Iodide Symporter (NIS): An Unending Source of Surprises" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Andres Jara-Oseguera (National Institute of Neurological Disorders and Stroke, NIH, USA) "Extracellular Sodium Is Required for Temperature-Dependent Gating in TRPV1 Channels" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Isabelle Mus-Veteau (CNRS, France) "The Human Hedgehog Receptor Patched Is a Cholesterol and a Drug Efflux Pump" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Benjamin Kaupp (Center of Advanced European Studies and Research, Germany) "Chemotactic Signaling by Exotic Ion Channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Calcium Release and Calcium-Gated Channels |
| Discussion Leader: Teresa Giraldez (La Laguna University, Spain) |
6:00 pm - 6:20 pm | Steve Long (Memorial Sloan Kettering Cancer Center, USA) "Structure and Insights into the Mechanism of the Bestrophin Calcium-Activated Chloride Channel" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Brad Rothberg (Temple University School of Medicine, USA) "An Intersubunit Ca2+ Bridge Contributes to BK Channel Gating" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Irina Serysheva (The University of Texas Medical School, USA) "Cryo-EM Structure of the IP3R1 Channel: Insights into the Gating Mechanism" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Manuel Arcangeletti (International School for Advanced Studies (SISSA), Italy) "Interactions Between the C-Linker and the S4-S5 Linker Mediate Gating in CNGA1 Channels" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Nieng Yan (Tsinghua University, China) "Molecular Visualization of the Excitation-Contraction Coupling" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Ligand-Gated Ion Channels |
| Discussion Leader: Anna Moroni (University of Milan, Italy) |
9:00 am - 9:20 am | Pierre-Jean Corringer (Pasteur Institute, France) "Gating Mechanism of a Bacterial Homolog of Pentameric Ligand-Gated Ion Channel" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Jorg Grandl (Duke University, USA) "Mechanism of Activation and Modulation of Piezo Ion Channels" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Peter Hegemann (Humboldt-Universitaet zu Berlin, Germany) "Operation of Light as Ligand for Channel and Enzyme Activation" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Andrea Saponaro (University of Milan, Italy) "HCN Channel Modulation: The Competition Between cAMP and TRIP8b Explained in Molecular Detail" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Henning Stahlberg (University of Basel, Switzerland) "A Prokaryotic Potassium Channel in Lipid Membranes Studied by Electron Crystallography" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Martina Rangl (INSERM U1006, France) "Real-Time Visualization of Conformational Changes in Ion Channels and Transporters by High-Speed Atomic Force Microscopy" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Eduardo Perozo (University of Chicago, USA) "On Symmetry and the Gating Mechanism of Ion Channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Technique Innovation |
| Discussion Leader: Simon Scheuring (INSERM U1006 / Aix-Marseille Université, France) |
6:00 pm - 6:20 pm | Gebhard Schertler (Paul Scherrer Institute / ETH Zürich, Switzerland) "The Application of Free Electron Lasers to Biology: A New Age of Time-Resolved Crystallography" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Carol Robinson (Oxford University, United Kingdom) "Membrane Proteins - The Lipid Connection" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Marina Casiraghi (IBPC Institut de Biologie Physico-Chimique, France) "Functional Remodelling of a GPCR Conformational Landscape in a Lipid Bilayer" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:35 pm | Maxime Dahan (Institut Curie, France) "Unraveling the Diffusivity and Energy Landscapes of Membrane Proteins with High Density Single Molecule Imaging" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Hervé Rémigy (FEI Company, The Netherlands) "Cryo-TEM: A Third Member Joins the High Resolution Band" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Permeation and Gating Mechanisms in Ion Channels and Transporters |
| Discussion Leader: Kenton Swartz (National Institutes of Health, USA) |
9:00 am - 9:20 am | Ann McDermott (Columbia University, USA) "Allosteric Coupling in KcsA: Ion Affinities by SSNMR" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Bert de Groot (Max Planck Institute for Biophysical Chemistry, Germany) "The Molecular Dynamics of Selective Permeation Across Biological Channels" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Colin Nichols (Washington University School of Medicine in St. Louis, USA) "Lipid Control of Ion Channels: smFRET and Crystallography Reveal the Intimate and Moving Details" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Francisco Bezanilla (University of Chicago, USA) "Following the Movement of the Charges in Voltage Sensors" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Thomas Baukrowitz (University of Kiel, Germany) "A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Jian Payandeh (Genentech, USA) "Cryo-What? Engineering Human Voltage-Gated Sodium Channels for Crystallography and Structure-Based Drug Design" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Simon Berneche (Swiss Institute of Bioinformatics, Switzerland) "The Proton Pathway in a ClC H+/Cl- Antiporter" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Dual Function and Exotic Channels and Transporters |
| Discussion Leader: Poul Nissen (Aarhus University, Denmark) |
6:00 pm - 6:20 pm | Christopher Miller (Brandeis University, USA) "Binding of Two Funky Ligands to One Weird Channel" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Julia Preobraschenski (Max Planck Institute for Biophysical Chemistry, Germany) "Vesicular Glutamate Transporters (VGLUTs) Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Alessio Accardi (Weill Cornell Medical College, USA) "Ion and Lipid Transport by TMEM16 Phospholipid Scramblases" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:35 pm | Jean-Ju Chung (Yale University, USA) "Ca2+ Signaling Components in Sperm Motility and Fertility" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Joel Meyerson (Brandeis University, USA) "Structural Mechanism of Glutamate Receptor Activation and Desensitization" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Transporter Mechanism |
| Discussion Leader: Cristina Paulino (University of Zurich, Switzerland) |
9:00 am - 9:20 am | Olga Boudker (Weill Cornell Medical College, USA) "Controlling Transporter Dynamics and Function" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Oezkan Yildiz (Max Planck Institute of Biophysics, Germany) "Citrate Recognition, Binding, and Transport by the Sodium-Dependent Citrate Symporter" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Jose Faraldo-Gomez (National Institutes of Health, USA) "Molecular Mechanism of the Na+/Ca2+ Exchanger: Insights from Computations and Experiments" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Werner Kuhlbrandt (Max-Planck-Institute for Biophysics, Germany) "Structure and Mechanisms of Archaeal Sodium/Proton Antiporters" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Homa Majd (MRC Mitochondrial Biology Unit, United Kingdom) "A High Throughput Method for Identification of Orphan Mitochondrial Transporters" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Dirk Jan Slotboom (University of Groningen, The Netherlands) "Toppling Mechanism of Energy Coupling Factor Vitamin Transporters" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrea Brueggemann (Nanion Technologies, Germany) "Novel Approaches to Study Ion Channels and Transporters" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Late-Breaking Topics |
| Discussion Leader: Chris Ahern (University of Iowa, USA) |
6:00 pm - 6:20 pm | Dimitrios Stamou (University of Copenhagen, Denmark) "Insights Gained from the First Measurements of Transport at the Single Molecule Level" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Marcel Goldschen-Ohm (University of Wisconsin-Madison, USA) "Single Molecule Ligand Binding Dynamics at Micromolar Concentrations in Zero-Mode Waveguides" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Filippo Mancia (Columbia University, USA) "Structure of a Micronutrient Transporter" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Jiafei Mao (Biomolecular Magnetic Resonance Center (BMRZ), Goethe-University Frankfurt, Germany) "Understanding Ligand Selectivity of GPCR Subtypes – A View of Peptide Ligands from Solid-State Nuclear Magnetic Resonance (SSNMR) Spectroscopy Enhanced by Dynamic Nuclear Polarization (DNP)" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Paul Shaffer (Amgen, Inc., USA) "Crystal Structures of the Glycine Receptor" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |